Circadian rhythm disturbance is a risk factor for obesity and chronic anovulation in women of reproductive age

Andreeva E.N.; Grigoryan O.R.; Sheremetyeva E.V.; Absatarova Yu.S.; Fursenko V.A.

doi:https://doi.org/10.17116/repro20202605136

Andreeva E.N.

Endocrinology Research Centre;
Moscow State University of Medicine and Dentistry

ORCID: 0000-0003-4979-7420

Grigoryan O.R.

A.I. Evdokimov Moscow State University of Medicine and Dentistry

ORCID: 0000-0003-4979-7420

Sheremetyeva E.V.

A.I. Evdokimov Moscow State University of Medicine and Dentistry

ORCID: 0000-0001-7177-0254

Absatarova Yu.S.

National Medical Research Center for Endocrinology

Fursenko V.A.

National Medical Research Center for Endocrinology

Circadian rhythm disturbance is a risk factor for obesity and chronic anovulation in women of reproductive age

Authors:

Andreeva E.N., Grigoryan O.R., Sheremetyeva E.V., Absatarova Yu.S., Fursenko V.A.

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Journal: Russian Journal of Human Reproduction. 2020;26(5): 36‑42

DOI: 10.17116/repro20202605136

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Andreeva EN, Grigoryan OR, Sheremetyeva EV, Absatarova YuS, Fursenko VA. Circadian rhythm disturbance is a risk factor for obesity and chronic anovulation in women of reproductive age. Russian Journal of Human Reproduction. 2020;26(5):36‑42. (In Russ.)
https://doi.org/10.17116/repro20202605136

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)

Использование инфографики авторами научных работ

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Abstract:

In the last decade, there has been growing interest in the physiological effects of hormonal regulation of the sleep-wake system, in particular, the pineal gland hormone melatonin. Melatonin is one of the key mediators of the effects of the pineal gland on the endocrine, immune and other body systems, including the regulation of the sleep-wake system. Sleep disorders are closely related to circadian rhythm disturbances — jet lag, disorder associated with shift work schedules, weekend insomnia, and others. Lack of sleep, along with the presence of a TV in the sleeping room (bedroom) and watching TV at bedtime are considered some of the possible causes of obesity. Obesity is a key link in the metabolic syndrome. By 2025, about 50% of women on our planet will be obese. Identification of early markers and risk factors for the development of metabolic syndrome in women of reproductive age is one of the priority areas of endocrine gynecology. Obesity and circadian rhythm disturbances by themselves and in combination are aggravating factors for the development of chronic anovulation syndrome, which in turn can lead to infertility, the risk of the pathological course of pregnancy and the threat to the health of the unborn child, as well as the risk of developing cancer in women of reproductive age.

Keywords:

obesity

sleep

reproduction

ovulation

circadian rhythms

metabolic syndrome

Authors:

Andreeva E.N.

Endocrinology Research Centre;
Moscow State University of Medicine and Dentistry

ORCID: 0000-0003-4979-7420

Grigoryan O.R.

A.I. Evdokimov Moscow State University of Medicine and Dentistry

ORCID: 0000-0003-4979-7420

Sheremetyeva E.V.

A.I. Evdokimov Moscow State University of Medicine and Dentistry

ORCID: 0000-0001-7177-0254

Absatarova Yu.S.

National Medical Research Center for Endocrinology

Fursenko V.A.

National Medical Research Center for Endocrinology

Received:

17.04.2020

Accepted:

01.06.2020

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References:

Vitaterna M, King D, Chang A, Kornhauser JM, Lowrey PL, McDonald JD, Dove WF, Pinto LH, Turek FW, Takahashi JS. Mutagenesis and mapping of a mouse gene, clock, essential for circadian behavior. Science. 1994;264(5159):719-725. https://doi.org/10.1126/science.8171325
Cagnacci A. Melatonin in relation to physiology in adult humans. Journal of Pineal Research. 1996;21(4):200-213. https://doi.org/10.1111/j.1600-079x.1996.tb00287.x
Melatonin: perspektivy primeneniya v klinike. Rapoport SI, ed M.: IMA-PRESS; 2012. (In Russ.).
Smythe G, Lazarus L. Growth Hormone Regulation by Melatonin and Serotonin. Nature. 1973;244(5413):230-231. https://doi.org/10.1038/244230a0
https://doi.org/10.14341/omet10340 https://doi.org/10.14341/omet10340
Volel BA, Ragimova AA, Burchakov DI, Burchakova MN, Kuznetsova IV. Stress-related menstrual disorders. Consilium Medicum. 2016;18(6):8-13. (In Russ).
Kamdar B, Tergas A, Mateen F, Bhayani N, Oh J. Night-shift work and risk of breast cancer: a systematic review and meta-analysis. Breast Cancer Research and Treatment. 2013;138(1):291-301. https://doi.org/10.1007/s10549-013-2433-1
Yuan X, Zhu C, Wang M, Mo F, Du W, Ma X. Night Shift Work Increases the Risks of Multiple Primary Cancers in Women: A Systematic Review and Meta-analysis of 61 Articles. Cancer Epidemiology Biomarkers and Prevention. 2018;27(1):25-40. https://doi.org/10.1158/1055-9965.epi-17-0221
The putative 82 causes of obesity. The downey obesity report. Accessed April 7, 2020. https://www.downeyobesityreport.com/2013/02/the-putative-82-causes-of-obesity
Smirnova VO. Vozmozhnosti korrektsii komponentov metabolicheskogo sindroma preparatom melatonina: diss. ... kand. med. nauk. Volgograd; 2018. (In Russ).
Cappuccio F, Taggart F, Kandala N, Currie A, Peile E, Stranges S, Miller MA. Meta-Analysis of Short Sleep Duration and Obesity in Children and Adults. Sleep. 2008;31(5):619-626. https://doi.org/10.1093/sleep/31.5.619
De Bacquer D, Van Risseghem M, Clays E, Kittel F, De Backer G, Braeckman L. Rotating shift work and the metabolic syndrome: a prospective study. International Journal of Epidemiology. 2009; 38(3):848-854. https://doi.org/10.1093/ije/dyn360
Jetten AM. Retinoid-Related Orphan Receptors (RORs): Critical Roles in Development, Immunity, Circadian Rhythm, and Cellular Metabolism. Nuclear Receptor Signaling. 2009;7(1):e003. https://doi.org/10.1621/nrs.07003
Maemura K, Takeda N, Nagai R. Circadian Rhythms in the CNS and Peripheral Clock Disorders: Role of the Biological Clock in Cardiovascular Diseases. Journal of Pharmacological Sciences. 2007; 103(2):134-138. https://doi.org/10.1254/jphs.fmj06003x2
Sisson S, Camhi S, Church T, Martin CK, Tudor-Locke C, Bouchard C, Earnest CP, Smith SR, Newton RL Jr, Rankinen T, Katzmarzyk PT. Leisure time sedentary behavior, occupational/domestic physical activity, and metabolic syndrome in U.S. men and women. Metabolic Syndrome and Related Disorders. 2009;7(6):529-536. https://doi.org/10.1089/met.2009.0023
Tsfasman AZ, Gorokhov VD, Alpaev DV. Circadian rhythms of melatonin secretion during nocturnal sleep deprivation. Problemy endokrinologii. 2013;59(2):40-44. (In Russ). https://doi.org/10.14341/probl201359240-44
Cipolla-Neto J, Amaral F, Afeche S, Tan D, Reiter R. Melatonin, energy metabolism, and obesity: a review. Journal of Pineal Research. 2014;56(4):371-381. https://doi.org/10.1111/jpi.12137
Reiter R, Tan D, Korkmaz A, Ma S. Obesity and metabolic syndrome: Association with chronodisruption, sleep deprivation, and melatonin suppression. Annals of Medicine. 2012;44(6):564-577. https://doi.org/10.3109/07853890.2011.586365
Waldhauser F, Frisch H, Waldhauser M, Weiszenbacher G, Zeitlhuber U, Wurtman R. Fall in nocturnal serum melatonin during prepuberty and pubescence. The Lancet. 1984;323(8373):362-365. https://doi.org/10.1016/s0140-6736(84)90412-4
Díaz López B, Díaz Rodríguez E, Urquijo C, Fernández Alvarez C. Melatonin Influences on the Neuroendocrine-Reproductive Axis. Annals of the New York Academy of Sciences. 2005;1057(1):337-364. https://doi.org/10.1196/annals.1356.026
Roy D, Belsham D. Melatonin Receptor Activation Regulates GnRH Gene Expression and Secretion in GT1-7 GnRH Neurons. Journal of Biological Chemistry. 2001;277(1):251-258. https://doi.org/10.1074/jbc.m108890200
Baker F, Driver H. Circadian rhythms, sleep, and the menstrual cycle. Sleep Medicine. 2007;8(6):613-622. https://doi.org/10.1016/j.sleep.2006.09.011
Lim A, Huang Z, Chua S, Kramer M, Yong E. Sleep Duration, Exercise, Shift Work and Polycystic Ovarian Syndrome-Related Outcomes in a Healthy Population: A Cross-Sectional Study. PLoS One. 2016;11(11):e0167048. https://doi.org/10.1371/journal.pone.0167048
Labyak S, Lava S, Turek F, Zee P. Effects of shiftwork on sleep and menstrual function in nurses. Health Care for Women International. 2002;23(6-7):703-714. https://doi.org/10.1080/07399330290107449
Lee K. Self-Reported Sleep Disturbances in Employed Women. Sleep. 1992;15(6):493-498. https://doi.org/10.1093/sleep/15.6.493
Preston FS, Bateman SC, Short RV, Wilkinson RT. Effects of flying and of time changes on menstrual cycle length and on performance in airline stewardesses. Aerospace Medicine. 1973;44(4):438-443.
Messing K, Saurel-Cubizolles M, Bourgine M, Kaminski M. Menstrual-cycle characteristics and work conditions of workers in poultry slaughterhouses and canneries. Scandinavian Journal of Work, Environment and Health. 1992;18(5):302-309. https://doi.org/10.5271/sjweh.1572
Uehata T, Sasakawa N. The fatigue and maternity disturbances of night workwomen. Journal of Human Ergology. 1982;11(Suppl):465-474.
Baumgartner A, Dietzel M, Saletu B, Wolf R, Campos-Barros A, Gräf KJ, Kürten I, Mannsmann U. Influence of partial sleep deprivation on the secretion of thyrotropin, thyroid hormones, growth hormone, prolactin, luteinizing hormone, follicle stimulating hormone, and estradiol in healthy young women. Psychiatry Research. 1993;48(2):153-178. https://doi.org/10.1016/0165-1781(93)90039-j
Axelsson G, Rylander R, Molin I. Outcome of pregnancy in relation to irregular and inconvenient work schedules. British Journal of Industrial Medicine. 1989;46(6):393-398. https://doi.org/10.1136/oem.46.6.393
Michels K, Mendola P, Schliep K, Yeung EH, Ye A, Dunietz GL, Wactawski-Wende J, Kim K, Freeman JR, Schisterman EF, Mumford SL. The influences of sleep duration, chronotype, and nightwork on the ovarian cycle. Chronobiology International. 2019;37(2): 260-271. https://doi.org/10.1080/07420528.2019.1694938
Andreeva EN, Grigoryan OR, Sheremetyeva EV, Absatarova YuS. Komorbidnost’: Sindrom polikistoznykh yaichnikov i ozhirenie. Uchebnoe posobie. M.: AMP Grupp; 2020. (In Russ.).
Spinedi E, Cardinali D. The Polycystic Ovary Syndrome and the Metabolic Syndrome: A Possible Chronobiotic-Cytoprotective Adjuvant Therapy. International Journal of Endocrinology. 2018;1349688. https://doi.org/10.1155/2018/1349868
Andreeva EN, Absatarova YuS, Sheremetyeva EV, Derkach DA, Ponomareva TA, Tyulpakov AN, Ioutsi VA, Ilyin AV, Murvatov KD. Analysis of the informativeness of melatonin evaluation in polycystic ovary syndrome. Ozhirenie i metabolizm. 2016;13(4):15-20. https://doi.org/10.14341/omet2016415-20
Lowes D, Webster N, Murphy M, Galley H. Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis. British Journal of Anaesthesia. 2013;110(3):472-480. https://doi.org/10.1093/bja/aes577
Soares J, Masana M, Erşahin Ç, Dubocovich M. Functional Melatonin Receptors in Rat Ovaries at Various Stages of the Estrous Cycle. Journal of Pharmacology and Experimental Therapeutics. 2003; 306(2):694-702. https://doi.org/10.1124/jpet.103.049916
Reiter R, Tamura H, Tan D, Xu X. Melatonin and the circadian system: contributions to successful female reproduction. Fertility and Sterility. 2014;102(2):321-328. https://doi.org/10.1016/j.fertnstert.2014.06.014
Tamura H, Takasaki A, Miwa I, Taniguchi K, Maekawa R, Asada H, Taketani T, Matsuoka A, Yamagata Y, Shimamura K, Morioka H, Ishikawa H, Reiter RJ, Sugino N. Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rate. Journal of Pineal Research. 2008; 44(3):280-287. https://doi.org/10.1111/j.1600-079x.2007.00524.x
Cappuccio F, D’Elia L, Strazzullo P, Miller M. Quantity and Quality of Sleep and Incidence of Type 2 Diabetes: A systematic review and meta-analysis. Diabetes Care. 2009;33(2):414-420. https://doi.org/10.2337/dc09-1124
Van Cauter E. Sleep disturbances and insulin resistance. Diabetic Medicine. 2011;28(12):1455-1462. https://doi.org/10.1111/j.1464-5491.2011.03459.x
Shreeve N, Cagampang F, Sadek K, Tolhurst M, Houldey A, Hill CM, Brook N, Macklon N, Cheong Y. Poor sleep in PCOS; is melatonin the culprit? Human Reproduction. 2013;28(5):1348-1353. https://doi.org/10.1093/humrep/det013
Shabani A, Foroozanfard F, Kavossian E, Aghadavod E, Ostadmohammadi V, Reiter RJ, Eftekhar T, Asemi Z. Effects of melatonin administration on mental health parameters, metabolic and genetic profiles in women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial. Journal of Affective Disorders. 2019;250:51-56. https://doi.org/10.1016/j.jad.2019.02.066
Cardinali DP, Cano P, Jiménez-Ortega V, Esquifino AI. Melatonin and the Metabolic Syndrome: Physiopathologic and Therapeutical Implications. Neuroendocrinology. 2011;93(3):133-142. https://doi.org/10.1159/000324699
Cardinali DP, Hardeland R. Inflammaging, Metabolic Syndrome and Melatonin: A Call for Treatment Studies. Neuroendocrinology. 2017;104(4):382-397. https://doi.org/10.1159/000446543
Rapoport SI, Molchanov AYu, Golichenkov VA, Burlakova OV, Suprunenko ES, Savchenko ES. Metabolic syndrome and melatonin. Klinicheskaya meditsina. 2013;91(11):8-14. (In Russ.).