Circadian rhythm disturbance is a risk factor for obesity and chronic anovulation in women of reproductive age

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In the last decade, there has been growing interest in the physiological effects of hormonal regulation of the sleep-wake system, in particular, the pineal gland hormone melatonin. Melatonin is one of the key mediators of the effects of the pineal gland on the endocrine, immune and other body systems, including the regulation of the sleep-wake system. Sleep disorders are closely related to circadian rhythm disturbances — jet lag, disorder associated with shift work schedules, weekend insomnia, and others. Lack of sleep, along with the presence of a TV in the sleeping room (bedroom) and watching TV at bedtime are considered some of the possible causes of obesity. Obesity is a key link in the metabolic syndrome. By 2025, about 50% of women on our planet will be obese. Identification of early markers and risk factors for the development of metabolic syndrome in women of reproductive age is one of the priority areas of endocrine gynecology. Obesity and circadian rhythm disturbances by themselves and in combination are aggravating factors for the development of chronic anovulation syndrome, which in turn can lead to infertility, the risk of the pathological course of pregnancy and the threat to the health of the unborn child, as well as the risk of developing cancer in women of reproductive age.

Keywords:

obesity

sleep

reproduction

ovulation

circadian rhythms

metabolic syndrome

Authors:

Andreeva E.N.

Endocrinology Research Centre;
Moscow State University of Medicine and Dentistry

ORCID: 0000-0003-4979-7420

Grigoryan O.R.

A.I. Evdokimov Moscow State University of Medicine and Dentistry

ORCID: 0000-0003-4979-7420

Sheremetyeva E.V.

A.I. Evdokimov Moscow State University of Medicine and Dentistry

ORCID: 0000-0001-7177-0254

Absatarova Yu.S.

National Medical Research Center for Endocrinology

Fursenko V.A.

National Medical Research Center for Endocrinology

Received:

17.04.2020

Accepted:

01.06.2020

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