The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Dobrokhotova Iu.É.

Kafedra akusherstva i ginekologii Moskovskogo fakul'teta Rossiĭskogo gosudarstvennogo meditsinskogo universiteta

Dzhokhadze L.S.

Kafedra akusherstva i ginekologii lechebnogo fakul'teta Rossiĭskogo gosudarstvennogo meditsinskogo universiteta

Preconception care as a real way to improve the perinatal outcomes

Authors:

Dobrokhotova Iu.É., Dzhokhadze L.S.

More about the authors

Journal: Russian Journal of Human Reproduction. 2019;25(6): 38‑43

DOI: 10.17116/repro20192506138

Read: 6956 times

Download PDF (RU)
Contact the author
Table of contents

PRECONCEPTION CARE AS A REAL WAY TO IMPROVE THE PERINATAL OUTCOMES
PRECONCEPTION CARE AS A REAL WAY TO IMPROVE THE PERINATAL OUTCOMES

To cite this article:

Dobrokhotova IuÉ, Dzhokhadze LS. Preconception care as a real way to improve the perinatal outcomes. Russian Journal of Human Reproduction. 2019;25(6):38‑43. (In Russ.)
https://doi.org/10.17116/repro20192506138

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Local cyto­kine profile of the endo­metrium in patients with repeated implantation failures and its pharmacological correction by the secretome of peri­pheral blood mono­nuclear cells. Russian Journal of Human Reproduction. 2024;(5):46-54
Immu­nological aspe­cts of reccurent pregnancy loss. Russian Journal of Human Reproduction. 2024;(5):64-71
Functional cyto­kine redu­ndancy in pregnancy. Russian Journal of Human Reproduction. 2024;(6):73-80
Clinical case of successful pregnancy in a patient with ecto­pic ACTH syndrome after radi­cal surgical treatment. Russian Journal of Human Reproduction. 2024;(6):118-123
Psoriasis in pregnant women. Russian Journal of Clinical Dermatology and Vene­reology. 2024;(5):517-524
Orga­nizational issues of reproductive health protection of adolescent girls in the system of the Fede­ral Medi­cal and Biological Agency of Russia. Russian Bulletin of Obstetrician-Gynecologist. 2024;(6):7-13
Pecu­liarities of placental microRNA expression in patients with preeclampsia and fetal growth restriction. Russian Bulletin of Obstetrician-Gynecologist. 2024;(6):14-25
Changes in the type of psychological component of the gestational domi­nant in pregnant women in the third trimester after completing the peri­natal preparation program. Russian Bulletin of Obstetrician-Gynecologist. 2024;(6):66-71
Sexual function of women during pregnancy. Russian Bulletin of Obstetrician-Gynecologist. 2024;(6):112-117
Dyna­mics of Substance P and Fila­ggrin Levels on Combined Treatment of Atopic Dermatitis with Emollient and Topi­cal Anti­pruritic Drug in Pregnant Women. Russian Journal of Clinical Dermatology and Vene­reology. 2024;(6):662-666
Abstract:

The article discusses the important problem of preconception period. The stages of the procedure, the importance of observing the intergenetic interval, the vaccination at the stage of pregnancy planning are described in detail. The need for nutritional support both at the stage of the preconception period and during pregnancy is particularly emphasized. The importance of an adequate content of vitamins and microelements before pregnancy is shown for the real prevention of fetal malformations, reduction of gestational complications, improvement of perinatal outcomes and postnatal fetal development. The role of Metafolin (a part of COC) is shown, taking into account the peculiarities of the biological transformation of folates. In this article the part on the role of COCs in the prevention and treatment of a number of gynecological diseases is also important. The article provides references to regulatory documents on interventions period.

Keywords:

preconception period
contraception
pregnancy
combined oral contraceptives (COC)
folate
neural tube defect (NTD)

Authors:

Dobrokhotova Iu.É.

Kafedra akusherstva i ginekologii Moskovskogo fakul'teta Rossiĭskogo gosudarstvennogo meditsinskogo universiteta

Dzhokhadze L.S.

Kafedra akusherstva i ginekologii lechebnogo fakul'teta Rossiĭskogo gosudarstvennogo meditsinskogo universiteta

Close metadata

References:

  1. WHO. Meeting to develop a global consensus on preconception care to reduce maternal and childhood mortality and morbidity. World Health Organization Headquarters, Geneva, 6—7 February 2012: meeting report. Accessed November 08, 2019. Available from: http://www.who.int/maternal_child_adolescent/documents/concensus_preconception_care/en/ [Meeting to develop a global consensus on preconception care to reduce maternal and childhood mortality and morbidity. Geneva: World Health Organization, 2013. Accessed November 08, 2019. (In Russ.). Available at:] http://apps. who.int/iris/handle/10665/78067
  2. De Franco EA, Ehrlich S, Muglia LJ. Influence of interpregnancy interval on birth timing. BJOG: British Journal of Obstetrics and Gynaecology. 2014;121(13):1633-1640.
  3. De Franco EA, Seske LM, Greenberg JM, Muglia LJ. Influence of interpregnancy interval on neonatal morbidity. American Journal of Obstetrics and Gynecology. 2015;212(3):386.e1-386.e9. https://doi.org/10.1016/j.ajog.2014.11.017
  4. Family planning: a global handbook for providers. Geneva, WHO; 2016. Accessed November 08, 2019. Available at: https://www.fphandbook.org
  5. Larsen B, Hwang J. Mycoplasma, Ureaplasma, and Adverse Pregnancy Outcomes: A Fresh Look. Infectious Diseases in Obstetrics and Gynecology. 2010;2010:521921. https://doi.org/10.1155/2010/521921
  6. CDC. General recommendations on immunization: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR: Morbidity and Mortality Weekly Report. Recommendations and Reports. 2011;60(2):26. Accessed November 08, 2019. Available at: https://www.cdc.gov/MMWR/Preview/MMWRhtml/rr6002a1.htm
  7. Federal’naya sluzhba gosudarstvennoj statistiki. Rosstat. Vyborochnoe nablyudenie reproduktivnyh planov naseleniya v 2017 godu. Tablica 21 «Srednij vozrast materi pri rozhdenii detej v raznye gody 2015—2017 gg.» Accessed November 08, 2019. (In Russ.). Available at: https://www.gks.ru/free_doc/new_site/RPN17/reports.html
  8. Rogers LM, Cordero AM, Pfeiffer CM, Hausman DB, Tsang BL, De-Regil LM, Rosenthal J, Razzaghi H, Wong EC, Weakland AP, Bailey LB. Global folate status in women of reproductive age: a systematic review with emphasis on methodological issues. Annals of the New York Academy of Sciences. 2018;1431(1):35-57. https://doi.org/10.1111/nyas.13963
  9. VOZ. Otsenka folatnogo statusa u razlichnyh grupp naseleniya po kontsentratsii folata v syvorotke krovi i krasnykh krovyanykh kletkakh. Informatsionnaya sistema dannykh o soderzhanii vitaminov i mineralov v produktakh pitaniya. Zheneva (VOZ), 2012. Accessed November 08, 2019. (In Russ.). Available at: http://www.who.int/iris/bitstream/10665/75584/4/WHO_NMH_NHD_EPG_12.1_rus pdf
  10. Daly LE, Kirke PN, Molloy A, Weir DG, Scott JM. Folate levels and neural tube defects. Implications for prevention. JAMA. 1995;274(21):1698-1702.
  11. Czeizel AE, Dobó M, Vargha P. Hungarian cohort-controlled trial of periconceptional multivitamin supplementation shows a reduction in certain congenital abnormalities. Birth Defects Research. Part A. Clinical and Molecular Teratology. 2004;70(11):853-861.
  12. Goh YI, Bollano E, Einarson TR, Koren G. Prenatal multivitamin supplementation and rates of congenital anomalies: a metaanalysis. Journal of Obstetrics and Gynaecology. 2006;28(8):680-689.
  13. Surén P, Roth C, Bresnahan M, Haugen M, Hornig M, Hirtz D, Lie KK, Lipkin WI, Magnus P, Reichborn-Kjennerud T, Schjølberg S, Davey Smith G, Øyen AS, Susser E, Stoltenberg C. Association between maternal use of folic acid supplements and risk of autism spectrum disorders in children. JAMA. 2013;309(6):570-577. https://doi.org/10.1001/jama.2012.155925
  14. Reijnders IF, Mulders AGMGJ, van der Windt M, Steegers EAP, Steegers-Theunissen RPM. The impact of periconceptional maternal lifestyle on clinical features and biomarkers of placental development and function: a systematic review. Human Reproduction Update. 2019;25(1):72-94. https://doi.org/10.1093/humupd/dmy037
  15. Figo Working Group on Best Practice in Maternal-Fetal Medicine; International Federation of Gynecology and Obstetrics. International Journal of Gynecology and Obstetrics. 2015;128(1):80-82.
  16. European Surveillance of Congenital Anomalies (EUROCAT) Special Report: Prevention of Neural Tube Defects by Periconceptional Folic Acid Supplementation in Europe. Part IIa — Country Specific Chapters (Austria to Ireland) and IIb — Country Specific Chapters (Italy to UK). 2009. Accessed October 30, 2019. Available at: https://www.researchgate.net/publication/291430176_Prevention_of_Neural_Tube_Defects_by_Periconceptional_Folic_Acid_Supplementation_in_Europe_Eurocat_Special_Report_May_2003
  17. Scaglione F, Panzavolta G. Folate, folic acid and 5-methyltetrahydrofolate are not the same thing. Xenobiotica. 2014;44(5):480-488. https://doi.org/10.3109/00498254.2013.845705
  18. Peng Y, Dong B, Wang Z. Serum folate concentrations and all-cause, cardiovascular disease and cancer mortality: A cohort study based on 1999-2010 National Health and Nutrition Examination Survey (NHANES). International Journal of Cardiology. 2016;219:136-142. https://doi.org/10.1016/j.ijcard.2016.06.024
  19. Zhou X, Meng Y. Association between serum folate level and cervical cancer: a meta-analysis. Archives of Gynecology and Obstetrics. 2016;293(4):871-877. https://doi.org/10.1007/s00404-015-3852-5
  20. Pietrzik K, Bailey L, Shane B. Folic acid and L-5-methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics. Clinical Pharmacokinetics. 2010;49(8):535-548. https://doi.org/10.2165/11532990-000000000-00000
  21. Tam C, O’Connor D, Koren G. Circulating unmetabolized folic acid: relationship to folate status and effect of supplementation. Obstetrics and Gynecology International. 2012;2012:485179. https://doi.org/10.1155/2012/485179
  22. Micle O, Muresan M, Antal L, Bodog F, Bodog A. The influence of homocysteine and oxidative stress on pregnancy outcome. Journal of Medicine and Life. 2012;5(1):68-73.
  23. Dobrohotova YuE, Suhih GT, Fajzullin LZ, Ochan TB, Jobava EM. The role of hyperhomocysteinemia in the Genesis of undeveloped pregnancy and miscarriage. Russkiy meditsinskiy zhurnal. 2010;13(17):1110-1112. (In Russ.)
  24. Dzhilandze NM, Ivanova LA. The use of dietary supplements by University students. Olymplus. Gumanitarnaya versiya. 2015;1:5-9. (In Russ.)
  25. Osterhues A, Holzgreve W, Michels KB. Shall we put the world on folate? Lancet. 2009;374(9694):959-961.
  26. Von Stenglin A, Buchwald S, Bannemerschult R. Awareness and periconceptional use of folic acid — results of a European study in women of childbearing age (abstract and oral presentation). The European Journal of Contraception and Reproductive Health Care. 2010; 15(s1):37-38 (abstract and oral presentation).
  27. Bart S, Marr J, Diefenbach K, Trummer D, Sampson-Landers C. Folate status and homocysteine levels during a 24-week oral administration of a folate-containing oral contraceptive: a randomized, double-blind, active-controlled, parallel-group, US-based multicenter study. Contraception. 2012;85(1):42-50. https://doi.org/10.1016/j.contraception.2011
  28. Cronin M, Schellschmidt I, Dinger J. Rate of pregnancy after using drospirenone and other progestin-containing oral contraceptives. Obstetrics and Gynecology. 2009;114(3):616-622. https://doi.org/10.1097/AOG.0b013e3181b46f54
  29. Crider KS, Yang TP, Berry RJ, Bailey LB. Folate and DNA methylation: a review of molecular mechanisms and the evidence for folate’s role. Advances in Nutrition. 2012;3(1):21-38. https://doi.org/10.3945/an.111.000992
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.