Interconnection between gene expression and signaling pathways activation profiles in eutopic and ectopic endometrium of patients with external genital endometriosis

Aznaurova Ya.B.; Petrov I.A.; Suntsova M.V.; Garazha A.V.; Buzdin A.A.; Adamyan L.V.

doi:https://doi.org/10.17116/repro20182404113

Aznaurova Ya.B.

Federal State University Scientific Center of obstetrics, gynecology and perynathology named after V.I. Kulakov, Ministry of Health of the Russian Federation, Moscow, Russia, 117997

Petrov I.A.

Department of Obstetrics and Gynecology, Siberian State Medical University, Ministry of Health of Russia, Tomsk, Russia

Suntsova M.V.

M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia

Garazha A.V.

M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia

Buzdin A.A.

M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia

Adamyan L.V.

Department of Reproductive Medicine and Surgery, Faculty of Postgraduate Professional Education, A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, Moscow, Russia

SPIN RSCI: 9836-2713
Scopus AuthorID: 7006372422
ResearcherID: Q-1722-2018
ORCID: 0000-0002-3253-4512

Interconnection between gene expression and signaling pathways activation profiles in eutopic and ectopic endometrium of patients with external genital endometriosis

Authors:

Aznaurova Ya.B., Petrov I.A., Suntsova M.V., Garazha A.V., Buzdin A.A., Adamyan L.V.

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Journal: Russian Journal of Human Reproduction. 2018;24(4): 13‑21

DOI: 10.17116/repro20182404113

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Aznaurova YaB, Petrov IA, Suntsova MV, Garazha AV, Buzdin AA, Adamyan LV. Interconnection between gene expression and signaling pathways activation profiles in eutopic and ectopic endometrium of patients with external genital endometriosis. Russian Journal of Human Reproduction. 2018;24(4):13‑21. (In Russ.)
https://doi.org/10.17116/repro20182404113

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)

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Abstract:

Objective — to carry out a transcriptomic analysis of eutopic and ectopic endometrial samples from patients with endometriosis and eutopic endometrial samples of women without endometriosis, to compare the transcriptomic profile of all mentioned samples. Material and methods. 6 patients with endometriosis and 3 patients with uterine scar incompetence after cesarean section were included in this study. Exclusion criteria were pelvic inflammatory disease, endometrial hyperplasia, uterine fibroids, adenomyosis, hormonal therapy or IUD use during a year prior to surgery. Results. This study demonstrates a certain number of signaling pathways and associated genes, which require close attention and further study in the samples of the eutopic and ectopic endometrium. Conclusions. There is a significant correlation in signaling pathways activation level between eutopic and ectopic endometrium taken from the same patient. For reliable detection of biomarkers and establishment of the test-system suitable for the diagnosis of endometriosis we need to analyze more samples of patients with endometriosis.

Keywords:

endometriosis

biomarkers

diagnostics

transcriptomic analysis

Authors:

Aznaurova Ya.B.

Federal State University Scientific Center of obstetrics, gynecology and perynathology named after V.I. Kulakov, Ministry of Health of the Russian Federation, Moscow, Russia, 117997

Petrov I.A.

Department of Obstetrics and Gynecology, Siberian State Medical University, Ministry of Health of Russia, Tomsk, Russia

Suntsova M.V.

M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia

Garazha A.V.

M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia

Buzdin A.A.

M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia

Adamyan L.V.

SPIN RSCI: 9836-2713
Scopus AuthorID: 7006372422
ResearcherID: Q-1722-2018
ORCID: 0000-0002-3253-4512

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References:

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