Fertility of adult in survivors of childhood Hodgkin lymphoma

Kurochkina D.N.; Kuleva S.A.

doi:https://doi.org/10.17116/repro20182404122

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Abstract:

Scientific literature search in electronic databases pubMed, Cochrane and eLibrary with 37 sources are included in this review. Chemotherapy, performed in childhood for girls, often leads to a reduction in the ovarian reserve and, as a result, early onset of menopause. Irradiation of the pelvis in children can further cause various gynecological diseases: miscarriage, stillbirth, fetal growth retardation, preeclampsia and premature birth. To the causes of infertility in men are the disorders of spermatogenesis, mechanical damage of the genitourinary system, testicular irradiation, sexual dysfunctions. Adults, both men and women, who were survived of childhood Hodgkin lymphoma, should evaluate fertility at the stage of pregnancy planning, so in case of problems arise, timely use of modern reproductive technologies.

Keywords:

pregnancy

Hodgkin’s lymphoma

ovarian reserve

infertility

spermatogenesis

fertility

Authors:

Kurochkina D.N.

Saint Petersburg Clinical Scientific and Practice Center of specializing types medical care, St-Petersburg, Russia

Kuleva S.A.

N.N. Petrov National Medical Research Center of Oncology, St-Petersburg, Russia

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References:

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