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Burlev V.A.

Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova, Moskva

Il'iasova N.A.

Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova, Moskva

Neuroangiogenesis in endometrium of women with endometriosis and chronic pelvic pain: high expression of vasoactive intestinal peptide

Authors:

Burlev V.A., Il'iasova N.A.

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Journal: Russian Journal of Human Reproduction. 2017;23(4): 87‑97

DOI: 10.17116/repro201723487-97

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NEUROANGIOGENESIS IN ENDOMETRIUM OF WOMEN WITH ENDOMETRIOSIS AND CHRONIC PELVIC PAIN: HIGH EXPRESSION OF VASOACTIVE INTESTINAL PEPTIDE
NEUROANGIOGENESIS IN ENDOMETRIUM OF WOMEN WITH ENDOMETRIOSIS AND CHRONIC PELVIC PAIN: HIGH EXPRESSION OF VASOACTIVE INTESTINAL PEPTIDE

To cite this article:

Burlev VA, Il'iasova NA. Neuroangiogenesis in endometrium of women with endometriosis and chronic pelvic pain: high expression of vasoactive intestinal peptide. Russian Journal of Human Reproduction. 2017;23(4):87‑97. (In Russ.)
https://doi.org/10.17116/repro201723487-97

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)
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Abstract:

Objectives — to estimate the intensity of the expression of VIP and VEGF-A in the vessels, the proliferative index in the vessels and in the epithelium of the glands, the density of CD31 and VIP in the eutopic endometrium, both in the control group and in patients with peritoneal form of endometriosis without chronic pelvic pain and with pain, and so to study the content of VIP, VEGF-A, IL-6 in the blood of the patients. Material and methods. Immunohistochemistry was used to study the expression of VIP, VEGF-A and microvessel density in eutopic endometrium in women with endometriosis. The ELISA method was used to determine the concentration of VIP, VEGF-A, IL-6 in serum. Results. It has been shown that patients with endometriosis and chronic pelvic pain have a higher expression of VIP in the eutopic endometrium than patients with endometriosis without chronic pain. Expression of VIP in the endometrium is the lowest in the control group. In patients with endometriosis in the blood, the VIP content is increased 2 times without pain and 2.7 times with pain in relation to control. The VIP content in the blood at a concentration of more 10 ng/ml allows predicting chronic pelvic pain in endometriosis with a sensitivity of 98.6% and a specificity of 79.3%. Conclusion. The VIP content in the blood can be used for an objective assessment of pain in endometriosis. Evaluation of the VIP expression in the eutopic endometrium can be used to characterize local lesions of neuroangiogenesis in endometriosis. The role of VIP in the pathogenesis of endometriosis with chronic pelvic pain establishes the rationale for a potential therapeutic goal.

Keywords:

endometriosis
eutopic endometrium
angiogenesis
neurogenesis

Authors:

Burlev V.A.

Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova, Moskva

Il'iasova N.A.

Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova, Moskva

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