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Adamyan L.V.

Russian University of Medicine;
National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I. Kulakov

Pivazyan L.G.

National medical research center for obstetrics, gynecology and perinatology named after academician V.I. Kulakov

Kurbatova K.S.

Department of Obstetrics, Gynecology and Reproductive Medicine, Russian University of Medicine

Chernetsova A.S.

Russian university of medicine

Murvatov K.D.

Russian University of Medicine

Sokolov A.D.

National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I. Kulakov

Arakelyan A.S.

National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I. Kulakov of the Ministry of Healthcare of Russian Federation

Asaturova A.V.

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after academician V.I. Kulakov

Mailova K.S.

FSBEI HE «RosUniMed» of MOH of Russia

Stepanian A.A.

Academia of Women’s Health and Endoscopic Surgery

Objectification of Pain in Patients with Endometriosis. (Literature review and own data)

Authors:

Adamyan L.V., Pivazyan L.G., Kurbatova K.S., Chernetsova A.S., Murvatov K.D., Sokolov A.D., Arakelyan A.S., Asaturova A.V., Mailova K.S., Stepanian A.A.

More about the authors

Journal: Russian Journal of Human Reproduction. 2025;31(2): 62‑85

DOI: 10.17116/repro20253102162

Read: 1672 times

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Table of contents

OBJECTIFICATION OF PAIN IN PATIENTS WITH ENDOMETRIOSIS. (LITERATURE REVIEW AND OWN DATA)
OBJECTIFICATION OF PAIN IN PATIENTS WITH ENDOMETRIOSIS. (LITERATURE REVIEW AND OWN DATA)

To cite this article:

Adamyan LV, Pivazyan LG, Kurbatova KS, et al. . Objectification of Pain in Patients with Endometriosis. (Literature review and own data). Russian Journal of Human Reproduction. 2025;31(2):62‑85. (In Russ.)
https://doi.org/10.17116/repro20253102162

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The article focuses on the of methods for objectifying pain syndrome in patients with endometriosis. Endometriosis-related pain, including dysmenorrhea, dyspareunia, and chronic pelvic pain, is a clinically significant symptom of the disease that leads patients to seek medical help and significantly reduces their quality of life. The article discusses the pathophysiological mechanisms of pain related to inflammation, abnormal innervation of endometrial foci, peripheral, central and cross-sensitization. Special attention is paid to modern methods for diagnosing pain caused by endometriosis, including the use of modified pain scales (PainDetect), analysis of biomarkers (neurotransmitters, sex hormones, immune markers and metabolites) in patient’ biosamples and assessment of histological features of the endometriotic lesions. Modern neuroimaging techniques such as MRI tractography, neurography and resting-state functional MRI are also described. These methods allow for evaluation of the presence of neuropathic components in pain syndromes associated with endometriosis. The article also describes methods for objectifying pain in animal models of endometriosis and highlights the potential of non-invasive tests for assessing chronic pain in humans. It emphasizes the need for developing and actively applying pain objectification techniques in patients with endometriosis, as a key aspect of early diagnosis and timely treatment to prevent disease progression.

Keywords:

endometriosis
pain
objectification
neuroimaging

Authors:

Adamyan L.V.

Russian University of Medicine;
National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I. Kulakov

Pivazyan L.G.

National medical research center for obstetrics, gynecology and perinatology named after academician V.I. Kulakov

Kurbatova K.S.

Department of Obstetrics, Gynecology and Reproductive Medicine, Russian University of Medicine

Chernetsova A.S.

Russian university of medicine

Murvatov K.D.

Russian University of Medicine

Sokolov A.D.

National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I. Kulakov

Arakelyan A.S.

National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I. Kulakov of the Ministry of Healthcare of Russian Federation

Asaturova A.V.

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after academician V.I. Kulakov

Mailova K.S.

FSBEI HE «RosUniMed» of MOH of Russia

Stepanian A.A.

Academia of Women’s Health and Endoscopic Surgery

Received:

20.03.2025

Accepted:

05.04.2025

Close metadata

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