Objective — to examine the possible role of polymorphic variants of genes of рrooxidants: the nicotinamide dinucleotide phosphate (NADPH/NADH oxidase (CYBA) C242T, 640А G substation in the p22phox), myeloperoxidase (MPO) (–G463A substation) and the gene of the antioxidant mitochondrial superoxide dismutase (SOD2) (А16V) in the development of hereditary preeclampsia. Material and methods. The research material was the blood serum samples of 49 women with severe preeclampsia (tested samples) and 48 women with physiological course of gestation (control samples). Genotyping was performed by polymerase chain reaction. Results. In a comparative analysis of the frequency of the polymorphic variants of the genes in tested and control samples, the allele G of the polymorphism rs 2332 of the MPO gene (–G463A substation) and the С allele of the polymorphic variant rs 48 of the SOD2 gene (A16V) are probably the markers of the hereditary predisposition to preeclampsia. Allele A of polymorphic variant rs 2332 of the MPO gene (–G463A substation) and allele T of the polymorphic variant rs 48 of the SOD2 gene (A16V), probably have a protective effect against the development of preeclampsia. The polymorphic variants rs 104 and rs 467 of the gene (NADPH/NADH oxidase (CYBA) C242T, 640A G substation in the p22phox) are not risk factors for the development of preeclampsia. Conclusion. It was established a possible involvement of the allele G of the polymorphism rs 2332 of the MPO gene (–G463A substation) to the structure of the hereditary predisposition in the development of preeclampsia. Allele A of polymorphic variant rs 2332 of the MPO gene (–G463A substation) and allele T of the polymorphic variant rs 48 of the SOD2 gene (A16V), probably have a protective effect against the development of preeclampsia.