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Nikolaeva M.G.

Obstetrics and Gynecology Department with the course of Supplementary Vocational Education in FSBEI of Higher Education «Altai State Medical University» Barnaul, Russia

Serdiuk G.V.

Hematology Research Center, Ministry of Health of Russia, Altai Branch, Barnaul;
Altai State Medical University, Ministry of Health of Russia, Barnaul

Gorbacheva T.I.

Altay State Medical University, Barnaul, Russia, 656038

Yavorskaya S.D.

Department of Obstetrics and Gynecology with Course of Additional Professional Education, Altai State Medical University, Ministry of Health of Russia, Barnaul, Russia

Momot A.P.

Altai Branch of the FSBI «National Research Center for Hematology», Barnaul, Russia

Relationship between preeclampsia and SERPINE1 (PAI-1-675 G4/G5) gene polymorphism. Systematic review. A metaanalysis

Authors:

Nikolaeva M.G., Serdiuk G.V., Gorbacheva T.I., Yavorskaya S.D., Momot A.P.

More about the authors

Journal: Russian Journal of Human Reproduction. 2016;22(4): 115‑122

DOI: 10.17116/repro2016224115-122

Read: 3615 times

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Table of contents

RELATIONSHIP BETWEEN PREECLAMPSIA AND SERPINE1 (PAI-1-675 G4/G5) GENE POLYMORPHISM. SYSTEMATIC REVIEW. A METAANALYSIS
RELATIONSHIP BETWEEN PREECLAMPSIA AND SERPINE1 (PAI-1-675 G4/G5) GENE POLYMORPHISM. SYSTEMATIC REVIEW. A METAANALYSIS

To cite this article:

Nikolaeva MG, Serdiuk GV, Gorbacheva TI, Yavorskaya SD, Momot AP. Relationship between preeclampsia and SERPINE1 (PAI-1-675 G4/G5) gene polymorphism. Systematic review. A metaanalysis. Russian Journal of Human Reproduction. 2016;22(4):115‑122. (In Russ.)
https://doi.org/10.17116/repro2016224115-122

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Objective. To identify, assess and synthesize existing scientific publications in Russian and international databases, aimed to find an association of polymorphism in the gene SERPINE1 (PAI-1 G4/G5) and pre-eclampsia. Material and methods. Databases PubMed and LIBRARY.RU were searched for publications. Statistical analysis was performed using the software packages SPSS 16.0 for Windows (SPSS Inc., США), calculation of odds ratio (OR) with 95% confidence interval (Cl) - with Comprehensive meta-analysis version 2.0. Results. There is a reliable risk of developing pre-eclampsia in the presence of PAI-1-675 (G5/G4) polymorphism. Risk of developing this complication is defined by Russian researchers as OR=1.2-1.95 (multiplicative model OR=1.2; 95% Cl 1.01-1.44; р=0.039; dominant model OR=1.92; 95% Cl 1.4-2.65; р=1·10–7; recessive model OR=1.95; 95% Cl 1.5-2.55; р=1·10–7); according to English sources OR is 1.17-1.6 (for recessive model from 1.17 to 1.60; 95% Cl 1.03-1.9; р<0,05; for dominant model OR=1.21; 95% Cl 1.01-1.44]). Conclusions. The polymorphism SERPINE1 gene plays a role in the pathogenesis of preeclampsia, but there is no evidence of effective routine screening for polymorphisms SERPINE1 to risk assessment of preclampsia.

Keywords:

polymorphism SERPINE1
meta-analysis
preclampsia risk

Authors:

Nikolaeva M.G.

Obstetrics and Gynecology Department with the course of Supplementary Vocational Education in FSBEI of Higher Education «Altai State Medical University» Barnaul, Russia

Serdiuk G.V.

Hematology Research Center, Ministry of Health of Russia, Altai Branch, Barnaul;
Altai State Medical University, Ministry of Health of Russia, Barnaul

Gorbacheva T.I.

Altay State Medical University, Barnaul, Russia, 656038

Yavorskaya S.D.

Department of Obstetrics and Gynecology with Course of Additional Professional Education, Altai State Medical University, Ministry of Health of Russia, Barnaul, Russia

Momot A.P.

Altai Branch of the FSBI «National Research Center for Hematology», Barnaul, Russia

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