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Isaev R.M.

Sechenov First Moscow State Medical University

Komarov R.N.

Sechenov First Moscow State Medical University;
Sechenov First Moscow State Medical University

Torchinsky N.V.

Sechenov First Moscow State Medical University

Gerasimov A.Ν.

Institute of Epidemiology

Polibin R.V.

Sechenov First Moscow State Medical University

Vyazovichenko Yu.E.

Sechenov First Moscow State Medical University

Tkachev M.I.

Sechenov First Moscow State Medical University

Belov Yu.V.

Sechenov First Moscow State Medical University

Valve-sparing approaches and valved conduits for aortic root surgery in patients with Marfan syndrome. Meta-analysis of immediate and long-term results

Authors:

Isaev R.M., Komarov R.N., Torchinsky N.V., Gerasimov A.Ν., Polibin R.V., Vyazovichenko Yu.E., Tkachev M.I., Belov Yu.V.

More about the authors

Journal: Russian Cardiology Bulletin. 2024;19(4): 13‑32

DOI: 10.17116/Cardiobulletin20241904113

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Table of contents

VALVE-SPARING APPROACHES AND VALVED CONDUITS FOR AORTIC ROOT SURGERY IN PATIENTS WITH MARFAN SYNDROME. META-ANALYSIS OF IMMEDIATE AND LONG-TERM RESULTS
VALVE-SPARING APPROACHES AND VALVED CONDUITS FOR AORTIC ROOT SURGERY IN PATIENTS WITH MARFAN SYNDROME. META-ANALYSIS OF IMMEDIATE AND LONG-TERM RESULTS

To cite this article:

Isaev RM, Komarov RN, Torchinsky NV, et al. . Valve-sparing approaches and valved conduits for aortic root surgery in patients with Marfan syndrome. Meta-analysis of immediate and long-term results. Russian Cardiology Bulletin. 2024;19(4):13‑32. (In Russ.)
https://doi.org/10.17116/Cardiobulletin20241904113

 
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Подписка 2026 Кардиологический вестник (Russian Cardiology Bulletin)
 
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Использование инфографики авторами научных работ
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Abstract:

Valve-sparing procedures in aortic root surgery demonstrate favorable short-term and long-term results. At the same time, the feasibility of valve-sparing procedures in patients with Marfan syndrome is questionable. This meta-analysis compares the immediate and long-term results of valve-sparing approaches and valved conduits in aortic root surgery for patients with Marfan syndrome. Data searching was performed in the MEDLINE, Embase, Cochrane and Web of Science databases. The primary endpoints were redo surgery rate and mortality in long-term period. Long-term aortic insufficiency (AI) +3/+4 was also estimated as a primary endpoint. Secondary endpoints included surgery for acute aortic dissection type A, 30-day mortality, thromboembolism, endocarditis and bleeding. Meta-analysis was carried out in accordance with the PRISMA recommendations 2020. In-hospital mortality was similar (OR 3.46; 95% CI 0.92—12.92; I2=0%; p=0.07). In long-term period, thromboembolism (OR 2.77; 95% CI 1.44—5.33; I2=0%; p=0.002), endocarditis (OR 3.19; 95% CI 1.18—8.61; I2=0%; p=0.02), bleeding (OR 3.46; 95% CI 1.76—6.77; I2=0%; p=0.0003) and mortality (OR 3.18; 95% CI 1.8—5.63; I2=12%; p<0.0001) were significantly more common after implantation of valved conduits. In long-term period, aortic insufficiency +3/+4 was more common after reimplantation (OR 0.17; 95% CI 0.05—0.52; I2=5%; p=0.002). In our study, valve-sparing procedures have advantage regarding the incidence of postoperative complications and mortality. However, long-term freedom from severe aortic insufficiency was higher after implantation of valved conduits.

Keywords:

Marfan syndrome
aortic root
David procedure
Bentall procedure
meta-analysis

Authors:

Isaev R.M.

Sechenov First Moscow State Medical University

Komarov R.N.

Sechenov First Moscow State Medical University;
Sechenov First Moscow State Medical University

Torchinsky N.V.

Sechenov First Moscow State Medical University

Gerasimov A.Ν.

Institute of Epidemiology

Polibin R.V.

Sechenov First Moscow State Medical University

Vyazovichenko Yu.E.

Sechenov First Moscow State Medical University

Tkachev M.I.

Sechenov First Moscow State Medical University

Belov Yu.V.

Sechenov First Moscow State Medical University

Received:

28.05.2024

Accepted:

30.08.2024

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