The role of angiogenesis markers in assisted reproductive technology programs in patients with different forms of infertility

Gerilovich L.A.; Salmina A.B.; Egorova A.T.; Bazina M.I.; Morgun A.V.; Syromiatnikova S.A.

doi:https://doi.org/

Gerilovich L.A.

OOO "Meditsinskiĭ tsentr ginekologicheskoĭ éndokrinologii i reproduktsii "Tri serdtsa", Krasnoiarsk;
Kafedra akusherstva i ginekologii instituta poslediplomnogo obrazovaniia GBOU VPO "Krasnoiarskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. prof. V.F. Voĭno-Iasenetskogo"

Salmina A.B.

Kafedra biologicheskoĭ khimii s kursami meditsinskoĭ farmatsevticheskoĭ i toksikologicheskoĭ khimii Krasnoiarskogo gosudarstvennogo meditsinskogo universiteta im. prof. V.F. Voĭno-Iasenetskogo, NII molekuliarnoĭ meditsiny i patobiokhimii, Krasnoiarsk

Egorova A.T.

Kafedra akusherstva i ginekologii Instituta poslediplomnogo obrazovaniia im. prof. V.F. Voĭno-Iasenetskogo Krasnoiarskogo gosudarstvennogo meditsinskogo universiteta

Bazina M.I.

Kafedra akusherstva i ginekologii Instituta poslediplomnogo obrazovaniia im. prof. V.F. Voĭno-Iasenetskogo Krasnoiarskogo gosudarstvennogo meditsinskogo universiteta

Morgun A.V.

Kafedra biokhimii s kursami meditsinskoĭ, farmatsevticheskoĭ i toksikologicheskoĭ khimii Nauchno-issledovatel'skogo instituta molekuliarnoĭ meditsiny i patobiokhimii Krasnoiarskogo gosudarstvennogo meditsinskogo universiteta im. prof. V.F. Voĭno-Iasenetskogo

Syromiatnikova S.A.

The role of angiogenesis markers in assisted reproductive technology programs in patients with different forms of infertility

Authors:

Gerilovich L.A., Salmina A.B., Egorova A.T., Bazina M.I., Morgun A.V., Syromiatnikova S.A.

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Journal: Russian Journal of Human Reproduction. 2013;(5): 60‑63

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To cite this article:

Gerilovich LA, Salmina AB, Egorova AT, Bazina MI, Morgun AV, Syromiatnikova SA. The role of angiogenesis markers in assisted reproductive technology programs in patients with different forms of infertility. Russian Journal of Human Reproduction. 2013;(5):60‑63. (In Russ.)

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)

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Abstract:

The paper presents the study of VEGF and sPECAM-1 levels in blood serum and follicular fluid in patients with different forms of infertility. We revealed the negative effect of high level of VEGF in blood serum on embryo implantation in tubal-peritoneal infertility and reverse interaction in endocrine infertility. The high concentration of VEGF in blood serum induces the increase of sPECAM-1 concentration in follicular fluid in induced cycles.

Keywords:

infertility

follicular fluid

angiogenesis markers

VEGF

sPECAM-1

ART outcomes

Authors:

Gerilovich L.A.

Salmina A.B.

Egorova A.T.

Kafedra akusherstva i ginekologii Instituta poslediplomnogo obrazovaniia im. prof. V.F. Voĭno-Iasenetskogo Krasnoiarskogo gosudarstvennogo meditsinskogo universiteta

Bazina M.I.

Kafedra akusherstva i ginekologii Instituta poslediplomnogo obrazovaniia im. prof. V.F. Voĭno-Iasenetskogo Krasnoiarskogo gosudarstvennogo meditsinskogo universiteta

Morgun A.V.

Syromiatnikova S.A.

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References:

Teplyashina E.A., Pozhilenkova E.A., Ekimova M.V. i dr. Faktory rosta, opredelyayushchie osobennosti follikulogeneza pri endokrinnom besplodii. Sib med obozrenie 2012; 6: 14-17.
Teplyashina E.A., Pozhilenkova E.A., Ekimova M.V. i dr. Rol' endotelina i sosudisto-endotelial'nogo faktora rosta v protsesse follikulogenez. Ros vestn akush-gin 2011; 3: 4-8.
Gavrilenko T.I., Ryzhkova N.A., Parkhomenko A.N. Sosudistyi endotelial'nyi faktor rosta v klinike vnutrennikh zabolevanii i ego patogeneticheskoe znachenie. Ukraїns'kii kardіologіchnii zhurn 2011; 4: 87-95.
Benifla J.L., Bringuier A.F., Sifer C. et al. Vascular endothelial growth factor, platelet endothelial cell adhesion molecule-1 and vascular cell adhesion molecule-1 in the follicular fluid of patients undergoing IVF. Hum Reprod 2001; 16: 7: 1367-1381.
Petrova M.M., Salmina A.B., Inzhutova A.I. i dr. Ingibitory APF - ratsional'naya farmakoterapiya endotelial'noi disfunktsii. Ratsional'naya farmakoterapiya v kardiologii 2008; 2: 89-92.
Ekimova M.V., Teplyashina E.A., Pozhilenkova E.A. i dr. Gumoral'nye faktory mikrookruzheniya ootsitov na raznykh stadiyakh rosta follikulov pri endokrinnom besplodii. Probl reprod 2011; 4: 19-22.
Monteleone P., Artini P.G., Simi G. et al. Follicular fluid VEGF levels directly correlate with perifollicular blood flow in normoresponder patients undergoing IVF. J Ass Reprod Genet 2008; 25: 5: 183-186.
Nazarenko T.A. Stimulyatsiya funktsii yaichnikov. M: MEDpress-inform 2008.
Bonello N., Norman R.J. Soluble adhesion molecules in serum throughout the menstrual cycle. Hum Reprod 2002; 17: 9: 2272-2278.
Savchev S.I., Moragianni V.A., Senger D. et al. Follicular fluid-specific distribution of vascular endothelial growth factor isoforms and sFlt-1 in patients undergoing IVF and their correlation with treatment outcomes. Reprod Sci 2010; 17: 11: 1036-1042.