The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Adamyan L.V.

Department of Reproductive Medicine and Surgery, Faculty of Postgraduate Professional Education, A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, Moscow, Russia

Sonova M.M.

Kafedra reproduktivnoĭ meditsiny i khirurgii fakul'teta poslediplomnogo obrazovaniia Moskovskogo gosudarstvennogo mediko-stomatologicheskogo universiteta

Loginova O.N.

Kafedra reproduktivnoĭ meditsiny i khirurgii fakul'teta poslediplomnogo obrazovaniia Moskovskogo gosudarstvennogo mediko-stomatologicheskogo universiteta

Tikhonova E.S.

Kafedra reproduktivnoĭ meditsiny i khirurgii fakul'teta poslediplomnogo obrazovaniia Moskovskogo gosudarstvennogo mediko-stomatologicheskogo universiteta

Iarotskaia E.L.

Kafedra reproduktivnoĭ meditsiny i khirurgii FPDO "Moskovskiĭ gosudarstvennyĭ mediko-stomatologicheskiĭ universitet im. A.I. Evdokimova"

Zimina É.V.

Kafedra reproduktivnoĭ meditsiny i khirurgii fakul'teta poslediplomnogo obrazovaniia Moskovskogo gosudarstvennogo mediko-stomatologicheskogo universiteta

Murdalova Z.Kh.

Kafedra reproduktivnoĭ meditsiny i khirurgii fakul'teta poslediplomnogo obrazovaniia Moskovskogo gosudarstvennogo mediko-stomatologicheskogo universiteta

Shamugia N.M.

Department of Reproductive Medicine and Surgery, Faculty of Postgraduate Professional Education, A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, Moscow, Russia

Laskevich A.V.

Department of Reproductive Medicine and Surgery, Faculty of Postgraduate Professional Education, A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, Moscow, Russia

The comparative analysis of effectiveness of dienogest and leuprorelin in the complex treatment of genital endometriosis

Authors:

Adamyan L.V., Sonova M.M., Loginova O.N., Tikhonova E.S., Iarotskaia E.L., Zimina É.V., Murdalova Z.Kh., Shamugia N.M., Laskevich A.V.

More about the authors

Journal: Russian Journal of Human Reproduction. 2013;(4): 33‑38

Views: 1362

Downloaded: 24

Download PDF (RU)
Contact the author
Table of contents

To cite this article:

Adamyan LV, Sonova MM, Loginova ON, et al. . The comparative analysis of effectiveness of dienogest and leuprorelin in the complex treatment of genital endometriosis. Russian Journal of Human Reproduction. 2013;(4):33‑38. (In Russ.)

 
МСФ на ЯМ
Close metadata
Recommended articles:
Immu­nological aspe­cts of endo­metriosis: pathophysiological mechanisms, diagnosis, autoimmunity, targeted therapy and modu­lation. Russian Journal of Human Reproduction. 2024;(2):15-31
Analysis of the effe­ctiveness of various methods of mana­ging patients with endo­metriosis and justification for long-term personalized anti-relapse therapy with dydrogesterone as part of their combination treatment stra­tegy. Russian Journal of Human Reproduction. 2024;(2):102-111
Infi­ltrating Endo­metriosis of the Distal Part of Round Uterine Liga­ment and It’s Asso­ciation with Nuck’s Dive­rticulum (Literature Review and Case Report). Russian Journal of Human Reproduction. 2024;(2):112-121
Endo­metriosis and geni­tal malformations in children and adolescents. What do they have in common?. Russian Journal of Human Reproduction. 2024;(3):14-22
Benign breast diseases in the focus of proliferative pathology of the reproductive system. Russian Journal of Human Reproduction. 2024;(3):33-42
Pathogenetic aspe­cts of chro­nic pelvic pain in endo­metriosis: diagnostic prospects (literature review). Russian Journal of Human Reproduction. 2024;(4):112-120
The role of systemic and local immu­nity in the pathogenesis of endo­metriosis of varying degrees of prevalence of the process: a modern view. Russian Journal of Human Reproduction. 2024;(5):6-14
The role of ferroptosis in reproduction. A modern view of the problem. Russian Journal of Human Reproduction. 2024;(5):35-45
The influence of endo­metriosis on the quality of life and reproductive function of modern woman. Russian Journal of Human Reproduction. 2024;(5):101-107
Quality of life and psychosomatic status of women of reproductive age with adenomyosis. Russian Bulletin of Obstetrician-Gynecologist. 2024;(5):83-89

The experience of dienogest 2 mg versus 3.75 mg leuprorelin usage in treatment of pain symptoms associated with endometriosis is presented. The efficiency of dienogest and leuprorelin was comparable regarding pain symptoms, clinical manifestations and the quality of life in patients with endometriosis. Toleration of endometriosis treatment with dienogest was better. Dienogest is an effective therapeutic alternative to GnRH agonists in the treatment of endometriosis.

Keywords:

endometriosis
endometriosis
dienogest
dienogest
gonadotropin-releasing hormone analogs
gonadotropin-releasing hormone analogs
pelvic pai
pelvic pai

Authors:

Adamyan L.V.

Department of Reproductive Medicine and Surgery, Faculty of Postgraduate Professional Education, A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, Moscow, Russia

Sonova M.M.

Kafedra reproduktivnoĭ meditsiny i khirurgii fakul'teta poslediplomnogo obrazovaniia Moskovskogo gosudarstvennogo mediko-stomatologicheskogo universiteta

Loginova O.N.

Kafedra reproduktivnoĭ meditsiny i khirurgii fakul'teta poslediplomnogo obrazovaniia Moskovskogo gosudarstvennogo mediko-stomatologicheskogo universiteta

Tikhonova E.S.

Kafedra reproduktivnoĭ meditsiny i khirurgii fakul'teta poslediplomnogo obrazovaniia Moskovskogo gosudarstvennogo mediko-stomatologicheskogo universiteta

Iarotskaia E.L.

Kafedra reproduktivnoĭ meditsiny i khirurgii FPDO "Moskovskiĭ gosudarstvennyĭ mediko-stomatologicheskiĭ universitet im. A.I. Evdokimova"

Zimina É.V.

Kafedra reproduktivnoĭ meditsiny i khirurgii fakul'teta poslediplomnogo obrazovaniia Moskovskogo gosudarstvennogo mediko-stomatologicheskogo universiteta

Murdalova Z.Kh.

Kafedra reproduktivnoĭ meditsiny i khirurgii fakul'teta poslediplomnogo obrazovaniia Moskovskogo gosudarstvennogo mediko-stomatologicheskogo universiteta

Shamugia N.M.

Department of Reproductive Medicine and Surgery, Faculty of Postgraduate Professional Education, A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, Moscow, Russia

Laskevich A.V.

Department of Reproductive Medicine and Surgery, Faculty of Postgraduate Professional Education, A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, Moscow, Russia

List of references:

  1. Adamyan L.V., Andreeva E.N. Rol' sovremennoi gormonmoduliruyushchei terapii v kompleksnom lechenii genital'nogo endometrioza. Probl reprod 2011; 6: 66-77.
  2. Andreeva E.N., Yarotskaya E.L., Adamyan L.V. Klinicheskii profil' rossiiskikh patsientok c diagnozom "genital'nyi endometrioz", poluchayushchikh lechenie agonistom gonadotropnogo rilizing-gormona. Rezul'taty rossiiskogo otkrytogo mnogotsentrovogo nablyudatel'nogo issledovaniya. Probl reprod 2011; 2: 50-62.
  3. Boguslavskaya D., Lebovic D. Endometrioz i besplodie. Probl reprod 2011; 2: 26-31.
  4. Chernukha G.E. Endometrioz i khronicheskaya tazovaya bol': prichiny i posledstviya. Probl reprod 2011; 6: 13-18.
  5. Novik A.A., Ionova T.I., Kaind P. Kontseptsiya issledovaniya kachestva zhizni v meditsine. SPb 1999.
  6. Kennedy S., Bergqvist A., Chapron C., D'Hooghe T., Dunselman G., Greb R., Hummelshoj L., Prentice A., Saridogan E. ESHRE guideline for the diagnosis and treatment of endometriosis. Hum Reprod 2005; 20: 2698-2704. doi: 10.1093/humrep/dei135.
  7. Jones G., Jenkinson C., Kennedy S. The impact of endometriosis upon quality of life: a qualitative analysis. J Psychosom Obstet Gynaecol 2004; 25: 123-133. doi: 10.1080/01674820400002279.
  8. Nnoaham K.E., Hummelshoj L., Webster P., D'Hooghe T., De Cicco Nardone F., De Cicco Nardone C., Jenkinson C., Kennedy S.H., Zondervan K.T. Impact of endometriosis on quality of life and work productivity: A multicenter study across ten countries. Fertil Steril 2011; 96: 366-373. doi: 10.1016/j.fertnstert.2011.05.090.
  9. Simoens S., Dunselman G., Dirksen C., Hummelshoj L., Bokor A., Brandes I., Brodszky V., Canis M., Colombo G.L., Deleire T. et al. The burden of endometriosis: costs and quality of life of women with endometriosis and treated in referral centres. Hum Reprod 2012; 27: 1292-1299. doi: 10.1093/humrep/des073.
  10. Sagsveen M., Farmer J.E., Prentice A., Breeze A. Gonadotrophin-releasing hormone analogues for endometriosis: bone mineral density. 2003; 4:CD001297.
  11. Küpker W., Felberbaum R.E., Krapp M., Schill T., Malik E., Diedrich K. Use of GnRH antagonists in the treatment of endometriosis. Reprod Biomed Online 2002; 5: 12-16.
  12. Leyland N., Casper R., Laberge Ph., Singh S.S. et al. Endometriosis: diagnosis and management. SOGC Clinical and practical guideline. J Obstet Gynaecol (Canada) 2010; 32: 7: 1-28.
  13. Kohler G., Faustmann T.A., Gerlinger C. et al. A dose-ranging study to determine the efficacy and safety of 1, 2, and 4 mg of dienogest daily for endometriosis. Int J Gynecol Obstet 2010; 108: 21-25.
  14. Strowitzki T., Faustmann T., Gerlinger C. et al. Dienogest in the treatment of endometriosis-associated pelvic pain: a 12-week, randomized, double-blind, placebo-controlled study. Eur J Obstet Gynecol Reprod Biol 2010; 151: 193-198.
  15. Cosson M., Querleu D., Donnez J. et al. Dienogest is as effective as triptorelin in the treatment of endometriosis after laparoscopic surgery: Results of a prospective, multicenter, randomized study. Fertil Steril 2002; 77: 4: 684-692.
  16. Strowitzki T., Marr J., Gerlinger C., Faustmann T., Seitz C. Dienogest is as effective as leuprolide acetate in treating the painful symptoms of endometriosis: a 24-week, randomized, multicentre, open-label trial. Hum Reprod 2010; 25: 3: 633-641.
  17. Harada T., Momoeda M., Taketani Y. et al. Dienogest is as effective as intranasal buserelin acetate for the relief of pain symptoms associated with endometriosis - a randomized, double-blind, multicenter, controlled trial. Fertil Steril 2009; 91: 3: 675-681.
  18. Barbieri R.L. Hormone treatment of endometriosis: the estrogen threshold hypothesis. Am J Obstet Gynecol 1992; 166: 740-745.
  19. Petraglia F., Hornung D., Seitz C. et al. Reduced pelvic pain in women with endometriosis: efficacy of long-term dienogest treatment. Arch Gynecol Obstet 2011; 285: 1: 167-173.
  20. Momoeda M., Harada T., Terakawa N. et al. Long-term use of dienogest for the treatment of endometriosis. J Obstet Gynaecol Res 2009; 35: 6: 1069-1076.
  21. Abbott J.A., Hawe J., Clayton R.D., Garry R. The effects and effectiveness of laparoscopic excision of endometriosis: a prospective study with 2-5 year follow-up. Hum Reprod 2003; 18: 1922-1927.
  22. Abbott J.A., Hawe J., Hunter D. et al. Laparoscopic excision of endometriosis: a randomized, placebo-controlled trial. Fertil Steril 2004; 82: 878-884.
  23. Olive D.L., Pritts E.A. Treatment of endometriosis. N Engl J Med 2001; 345: 266-275.
  24. Srosignani P.G., Olive D. et al. Advances in the management of endometriosis: an update for clinicians. Hum Reprod Update 2006; 12: 179-189.
  25. Horie S., Harada T. et al. Progesterone and progestational compounds attenuate tumor necrosis factor alpha-induced interleukin-8 production via nuclear factor kappa B inactivation in endometriotic stromal cells. Fertil Steril 2005; 83: 1530-1535.
  26. Practice Committee of the American Society for Reproductive Medicine. Fertil Steril 2008; 90: 260-269.
  27. Jo Kitawaki, Izumi Kusuki, Kaoruko Yamanaka, Izumi Suganuma. Maintenance therapy with dienogest following gonadotropin-releasing hormone agonist treatment for endometriosis-associated pelvic pain. Eur J Obstet Gynecol Reprod Biol 2011; 157: 212-216.

Close metadata

Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.