Participation of nf-kb factor and its regulatory proteins in the development of complicated pregnancy

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The activity of p65 subunit of transcriptional factor NF-kB during physiological and complicated pregnancy was investigated. The decrease of NF-kB activity during fetal growth retardation and preeclampsia was observed. The correlation with the disorders of the activity regulators expression was demonstrated. The possible mechanisms of the revealed disorders and their role in the development of complicated pregnancy are discussed.

Keywords:

transcriptional factor NF-kB

pregnancy

amniotic fluid

protein

Authors:

Gun'ko V.O.

Rostovskiĭ NII akusherstva i pediatrii

Pogorelova T.V.

FGU "Rostovskiĭ NII akusherstva i pediatrii" Minzdrava RF, Rostov-na-Donu

Linde V.A.

Rostovskiĭ NII akusherstva i pediatrii

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