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Druzhinina A.S.

Endocrinology Research Centre, Moscow, Russia

Vitiazeva I.I.

FGBU Éndokrinologicheskiĭ nauchnyĭ tsentr Minzdravsotsrazvitiia Rossiĭskoĭ Federatsii

Pathogenetic features of immunological disorders in women with thyroid peroxidase antibodies presence and their effect on infertility treatment by in vitro fertilization (IVF)

Authors:

Druzhinina A.S., Vitiazeva I.I.

More about the authors

Journal: Problems of Endocrinology. 2019;65(4): 289‑294

DOI: 10.14341/probl10298

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Table of contents

PATHOGENETIC FEATURES OF IMMUNOLOGICAL DISORDERS IN WOMEN WITH THYROID PEROXIDASE ANTIBODIES PRESENCE AND THEIR EFFECT ON INFERTILITY TREATMENT BY IN VITRO FERTILIZATION (IVF)
PATHOGENETIC FEATURES OF IMMUNOLOGICAL DISORDERS IN WOMEN WITH THYROID PEROXIDASE ANTIBODIES PRESENCE AND THEIR EFFECT ON INFERTILITY TREATMENT BY IN VITRO FERTILIZATION (IVF)

To cite this article:

Druzhinina AS, Vitiazeva II. Pathogenetic features of immunological disorders in women with thyroid peroxidase antibodies presence and their effect on infertility treatment by in vitro fertilization (IVF). Problems of Endocrinology. 2019;65(4):289‑294. (In Russ.)
https://doi.org/10.14341/probl10298

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Abstract:

Autoimmune thyroiditis (AIT) is the most common thyroid disease among women of fertile age. An increase of thyropercosidase antibodies (TPO-Ab) occupies one of the leading positions among other autoantibodies in patients with idiopathic infertility. Stimulation of superovulation in assisted reproductive technology (ART) programs leads to thyroid overstimulation, relative hypothyroxinemia and an increase of thyroid stimulating hormone (TSH) level in women with positive TPO-Ab carrier state, leading to a decrease in the reserve capacity of the thyroid affected by the autoimmune process. There is a large number of studies concerning the effect of autoimmune thyroid diseases on the infertility treatment outcomes in ART programs, but the results are contradictory. One of the hypotheses is that TPO-Ab affect the embryo implantation process in the uterus, based on an imbalance of cytokine production by T-helper type 1, 2, and 17, which are not easy to correct by classical hormone replacement therapy with levothyroxine. Nowadays, the immunological mechanisms of these disorders are not well investigated.

Keywords:

positive TPO-Ab carrier state
in vitro fertilization and embryos transfer
pregnancy
cytokines
implantation

Authors:

Druzhinina A.S.

Endocrinology Research Centre, Moscow, Russia

Vitiazeva I.I.

FGBU Éndokrinologicheskiĭ nauchnyĭ tsentr Minzdravsotsrazvitiia Rossiĭskoĭ Federatsii

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References:

  1. rosminzdrav.ru [internet]. Ministerstvo zdravookhraneniya Rossiiskoi Federatsii, Departament monitoringa, analiza i strategicheskogo razvitiya zdravookhraneniya; FGBU «Tsentral’nyi nauchno-issledovatel’skii institut organizatsii i informatizatsii zdravookhraneniya» Minzdrava Rossii. Zabolevaemost’ vsego naseleniya Rossii v 2017 godu. Statisticheskie materialy [cited 2019 Aug 26]. (In Rus.) https://www.rosminzdrav.ru/ministry/61/22/stranitsa-979/statisticheskie-i-informatsionnye-materialy/statisticheskiy-sbornik-2017-god.
  2. Perminova SG. Thyroid dysfunction in infertile women. Clinical and experimental thyroidology. 2011;7(4):44–50. (In Rus.)
  3. Fadeyev VV. Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and postpartum. Clinical and experimental thyroidology. 2012;8(1):7–18. (In Rus.)
  4. Melmed S, Polonsky K, Larsen P, et al. Williams textbook of endocrinology. 13th ed. Philadelphia, PA: Elsevier; 2015. 1936 p.
  5. Gardner DG, Shobeck D. Greenspan’s basic & clinical endocrinology. Translated from English by Mel’nichenko G.A., Kondror V.I., Starostin E.G. Moscow: Binom; 2019. 464 p. (In Rus.)
  6. Perminova SG. Infertility in women with thyroid diseases: principles of diagnosis, management. Akusherstvo i ginekologiya: novosti, mneniya, obuchenie. 2013;2: 18–24. (In Rus.)
  7. Sammaritano L. Pregnancy in rheumatic disease patients. J Clin Rheumatol. 2013;19(5):259–266. https://doi.org/10.1097/rhu.0b013e31829ce35f.
  8. Guleria I, Sayegh M. Maternal acceptance of the fetus: true human tolerance. J Immunol. 2007;178(6):3345–3351. https://doi.org/10.4049/jimmunol.178.6.3345.
  9. Shi Y, Wang H, Su Z, et al. Differentiation imbalance of Th1/Th17 in peripheral blood mononuclear cells might contribute to pathogenesis of Hashimoto’s thyroiditis. Scand J Immunol. 2010;72(3):250–255. https://doi.org/10.1111/j.1365-3083.2010.02425.x.
  10. Saito S, Nakashima A, Ito M, Shima T. Clinical implication of recent advances in our understanding of IL-17 and reproductive immunology. Expert Rev Clin Immunol. 2011;7(5):649–657. https://doi.org/10.1586/eci.11.49.
  11. Alijotas-Reig J, Llurba E, Gris JM. Potentiating maternal immune tolerance in pregnancy: a new challenging role for regulatory T cells. Placenta. 2014;35(4):241–248. https://doi.org/10.1016/j.placenta.2014.02.004.
  12. Brown RS. Autoimmune thyroid disease: unlocking a complex puzzle. Curr Opin Pediatr. 2009;21(4):523–528. https://doi.org/10.1097/mop.0b013e32832cf824.
  13. Orlova MM, Rodionova TI. The pro-inflammatory cytokines deviation in patients with clinical hypothyroidism. Dal’nevostochnyi meditsinskii zhurnal. 2012;1:26. (In Rus.)
  14. Turhan Iyidir O, Konca Degertekin C, Sonmez C, et al. The effect of thyroid autoimmunity on T-cell responses in early pregnancy. J Reprod Immunol. 2015;110:61–66. https://doi.org/10.1016/j.jri.2015.04.002.
  15. Krysiak R, Okopien B. The effect of levothyroxine and selenomethionine on lymphocyte and monocyte cytokine release in women with Hashimoto’s thyroiditis. J Clin Endocrinol Metab. 2011;96(7):2206–2215. https://doi.org/10.1210/jc.2010-2986.
  16. Guclu F, Ozmen B, Kirmaz C, et al. Down-regulation of the auto-aggressive processes in patients with hypothyroid Hashimoto’s thyroiditis following substitutive treatment with L-thyroxine. Eur Cytokine Netw. 2009;20(1):27–32. https://doi.org/10.1684/ecn.2009.0147.
  17. Huang C, Liang P, Diao L, et al. Thyroid autoimmunity is associated with decreased cytotoxicity T cells in women with repeated implantation failure. Int J Environ Res Public Health. 2015; 12(9):10352–10361. https://doi.org/10.3390/ijerph120910352.
  18. Simopoulou M, Sfakianoudis K, Maziotis E, et al. The impact of autoantibodies on IVF treatment and outcome: a systematic review. Int J Mol Sci. 2019;20(4):e892. https://doi.org/10.3390/ijms20040892.
  19. Weghofer A, Himaya E, Kushnir V, et al. The impact of thyroid function on embryo quality for in vitro fertilization (IVF). Fertil Steril. 2013;100(3 Suppl):S333. https://doi.org/10.1016/j.fertnstert.2013.07.916.
  20. Sharfi YuN. Cytokines and growth factors as markers of endometrium implantation capacity in IVF. Journal of obstetrics and women’s diseases. 2013;62(4):88–96. (In Rus.) https://doi.org/10.17816/jowd62488-96.
  21. Motovilova NO, Kogan IYu, Syssoev KA, et al. Impact of some cytokines to efficiency of infertility treatment by means of in vitro fertilization. Medical Immunology. 2012;14(4–5):373–382. (In Rus.) https://doi.org/ 10.15789/1563-0625-2012-4-5-373-382.
  22. Druzhinina AS, Vityazeva II. Vzaimosvyaz’ urovnei tireotropnogo gormona, antitel k tireoperoksidaze i effektivnosti lecheniya besplodiya metodom ekstrakorporal’nogo oplodotvoreniya. In: Proceedings of XXIX Annual International Conference RARCh «Reproduktivnye tekhnologii segodnya i zavtra»; Rostov-on-Don, 4–7 September 2019. Rostov-on-Don; 2019. (In Rus.)
  23. Poppe K, Glinoer D, Tournaye H, et al. Assisted reproduction and thyroid autoimmunity: an unfortunate combination? J Clin Endocrinol Metab. 2003;88(9):4149–4152. https://doi.org/10.1210/jc.2003-030268.
  24. Negro R, Formoso G, Coppola L, et al. Euthyroid women with autoimmune disease undergoing assisted reproduction technologies: the role of autoimmunity and thyroid function. J Endocrinol Invest. 2007;30(1):3–8. https://doi.org/10.1007/bf03347388.
  25. Kutteh WH, Schoolcraft WB, Scott RT Jr. Antithyroid antibodies do not affect pregnancy outcome in women undergoing assisted reproduction. Hum Reprod. 1999;14(11):2886–2890. https://doi.org/10.1093/humrep/14.11.2886.
  26. Kostareva OS, Gabdulkhakov AG, Kolyadenko IA, et al. Interleikin-17: funktsional’nye i strukturnye osobennosti; ispol’zovanie v kachestve terapevticheskoĭ misheni. Uspekhi biologicheskoiy khimii. 2019;59:393–418. (In Rus.)
  27. Fröhlich E, Wahl R. Thyroid autoimmunity: role of anti-thyroid antibodies in thyroid and extra-thyroidal diseases. Front Immunol. 2017;8:521. https://doi.org/10.3389/fimmu.2017.00521.
  28. Krylova YuS, Kvetnoy IM, Aylamazyan EK. Endometrial receptivity: the molecularmechanisms regulation of implantation. Journal of obstetrics and women’s diseases. 2013;62(2):63–74. (In Rus.) https://doi.org/ 10.17816/JOWD62263-74.
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