Influence of obesity on sperm DNA fragmentation index and outcomes of IVF programs

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The reduction of the birth rates in the developed countries and increase in the frequency of male infertility stimulate the extensive investigations for the factors that negatively affect the reproductive system of the men and causing their infertility. The excessive body weight and obesity in the men of the reproductive age can promote the development of infertility. One of the mechanisms by which excess fat tissue has a negative impact on male fertility is disturbance of spermatogenesis. The authors aggregate scientific publications concerning the macroscopic and ultrastructural disturbances of spermatogenesis in men with obesity. We present the results of the study conducted at the Department of ART Endocrinology Research Center, targeted at the revelation of the relationship of body mass index of men of reproductive age, semen parameters, sperm DNA fragmentation index, as well as the influence of body mass index on outcomes of in vitro fertilization programs.

Keywords:

infertility

obesity

overweight

male

sperm

semen

dna fragmentation

assisted reproductive technology

biochemical pregnancy

reproductive loss

in vitro fertilization

Authors:

Vitiazeva I.I.

FGBU Éndokrinologicheskiĭ nauchnyĭ tsentr Minzdravsotsrazvitiia Rossiĭskoĭ Federatsii

Altashina M.V.

FGBU "ndokrinologicheskiĭ nauchnyĭ tsentr" Minzdrava Rossii, Moskva

Mun T.V.

Endocrinology Research Centre, Moscow, Russia

Troshina E.A.

Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

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