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Markova T.N.

Kafedra vnutrennikh bolezneĭ Chuvashskogo gosudarstvennogo universiteta, Cheboksary

Kichigin V.A.

Kafedra vnutrennikh bolezneĭ Chuvashskogo gosudarstvennogo universiteta, Cheboksary

Madianov I.V.

Kafedra terapii i semeĭnoĭ meditsiny Instituta usovershenstvovaniia vracheĭ, Cheboksary

Semenova T.N.

Kafedra vnutrennikh bolezneĭ Chuvashskogo gosudarstvennogo universiteta, Cheboksary

Population-based genetic analysis of the prevalence of obesity in Chuvash Republic

Authors:

Markova T.N., Kichigin V.A., Madianov I.V., Semenova T.N.

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Journal: Problems of Endocrinology. 2010;56(4): 16‑19

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Table of contents

POPULATION-BASED GENETIC ANALYSIS OF THE PREVALENCE OF OBESITY IN CHUVASH REPUBLIC
POPULATION-BASED GENETIC ANALYSIS OF THE PREVALENCE OF OBESITY IN CHUVASH REPUBLIC

To cite this article:

Markova TN, Kichigin VA, Madianov IV, Semenova TN. Population-based genetic analysis of the prevalence of obesity in Chuvash Republic. Problems of Endocrinology. 2010;56(4):16‑19. (In Russ.)

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Abstract:

The objective of the present work was to study the prevalence of obesity among 271 residents of the Chuvash Republic taking account of their sex and ethnic background. Simultaneously, genetic predisposition to obesity was assessed from the presence or absence of this condition in 955 blood relatives of the probands using Edwards' coefficient of genetic determination and coefficient of association. Results of the study suggest higher prevalence of obesity in women than in men and in Russians compared with Chuvashes. Genetic determination of obesity was found to be independent of sex and type of fat distribution. The risk of developing obesity proved to be significantly higher in the probands from families in which both parents were obese than from those with only one obese parent.

Keywords:

obesity
population genetics
coefficient of genetic determination

Authors:

Markova T.N.

Kafedra vnutrennikh bolezneĭ Chuvashskogo gosudarstvennogo universiteta, Cheboksary

Kichigin V.A.

Kafedra vnutrennikh bolezneĭ Chuvashskogo gosudarstvennogo universiteta, Cheboksary

Madianov I.V.

Kafedra terapii i semeĭnoĭ meditsiny Instituta usovershenstvovaniia vracheĭ, Cheboksary

Semenova T.N.

Kafedra vnutrennikh bolezneĭ Chuvashskogo gosudarstvennogo universiteta, Cheboksary

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References:

  1. Seidell J.S. The worldwide epidemic of obesity. In: Progress in obesity research. 8th International congress of obesity. B. Guy-Grand, G. Aikhaud, eds. London: John Libbey & Company Ltd 1999; 661-668.
  2. Reaven G.M. Banting. Diabetes 1988; 37: 1595-1607.
  3. Vorokhobina N.V., Baranovskii A.Yu., Volkova E.A. Ozhirenie: etiologiya, patogenez, klinika i lechenie. V kn.: Ozhirenie (klinicheskie ocherki). Pod red. prof. A.Yu. Baranovskogo, prof. N.V. Vorokhobinoi. St-Peterburg: Dialekt 2007.
  4. Fogel' F. Genetika cheloveka: V 3 tomakh. T. 2. Per. s angl. M: Mir 1990.
  5. Bochkov N.P. Klinicheskaya genetika. M: GEOTAR-Med 2002.
  6. Edwards J.H. Familial predisposition in men. Br Med Bull 1969; 25: 1: 58-64.
  7. Sirotkin V.M., Chuprun V.F. Opyt populyatsionno-genetiche­skogo analiza v mikroochagakh endemicheskogo zoba. Probl endokrinol 1979; 4: 21-27.
  8. Fadeev V.V., Abramova N.A. Geneticheskie faktory v patogeneze ioddefitsitnogo zoba. Probl endokrinol 2004; 1: 51-55.
  9. Fletcher R.E., Fletcher S., Vagner E. Klinicheskaya epidemiologiya. M: Media Sfera 1998.
  10. Kichigin V.A., Markova T.N., Madyanov I.V. Sposob otsenki geneticheskoi determinatsii ozhireniya: ratsionalizatorskoe predlozhenie. Udostoverenie na ratsionalizatorskoe predlozhenie № 1149 ot 30 oktyabrya 2008 g., vydannoe Chuvashskim gosudarstvennym universitetom imeni I.N. Ul'yanova 31.10.2008 g.
  11. Kaminskii L.S. Statisticheskaya obrabotka laboratornykh i klinicheskikh dannykh. L: Meditsina 1964.
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