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Kravets E.B.

Sibirskiĭ gosudarstvennyĭ meditsinskiĭ universitet, Tomsk

Urazova O.I.

Sibirskiĭ gosudarstvennyĭ meditsinskiĭ universitet, Tomsk

Nedosekova Iu.V.

Sibirskiĭ gosudarstvennyĭ meditsinskiĭ universitet, Tomsk

Rogaleva A.V.

Sibirskiĭ gosudarstvennyĭ meditsinskiĭ universitet, Tomsk

Apoptosis of blood lymphocytes in autoimmune thyropathies

Authors:

Kravets E.B., Urazova O.I., Nedosekova Iu.V., Rogaleva A.V.

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Journal: Problems of Endocrinology. 2010;56(3): 16‑20

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APOPTOSIS OF BLOOD LYMPHOCYTES IN AUTOIMMUNE THYROPATHIES
APOPTOSIS OF BLOOD LYMPHOCYTES IN AUTOIMMUNE THYROPATHIES

To cite this article:

Kravets EB, Urazova OI, Nedosekova IuV, Rogaleva AV. Apoptosis of blood lymphocytes in autoimmune thyropathies. Problems of Endocrinology. 2010;56(3):16‑20. (In Russ.)

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This paper reports the results of a study of lymphocyte apoptosis in the blood of 81 patients presenting with autoimmune thyropathies, such as autoimmune thyroidism (AIT) and Grave's disease (GD). It was shown that AIT in patients with hypothyroidism and DTG is associated with an increased number of CD95+ lymphocytes «doomed» to apoptose. Moreover, AIT and DTG conditions are characterized by an elevated level of serum tumour necrosis factor-alpha (TNF-α). In euthyroid patients with AIT, this rise is accompanied by a decrease in the interferon-gamma (IFN-γ) level. Hypotyroid patients with AIT exhibit positive relationship between an increased number of CD95+ lymphocytes in blood and serum TNF-α levels.

Keywords:

autoimmune thyropathies
diffuse toxic goiter
lymphocytes
apoptosis
cytokines

Authors:

Kravets E.B.

Sibirskiĭ gosudarstvennyĭ meditsinskiĭ universitet, Tomsk

Urazova O.I.

Sibirskiĭ gosudarstvennyĭ meditsinskiĭ universitet, Tomsk

Nedosekova Iu.V.

Sibirskiĭ gosudarstvennyĭ meditsinskiĭ universitet, Tomsk

Rogaleva A.V.

Sibirskiĭ gosudarstvennyĭ meditsinskiĭ universitet, Tomsk

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