The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Manturova N.E.

Pirogov Russian National Research Medical University;
Institute of Plastic Surgery and Cosmetology

Stupin V.A.

Pirogov Russian National Research Medical University;
Institute of Plastic Surgery and Cosmetology

Orlova A.S.

Sechenov First Moscow State Medical Univesity

Silina E.V.

Sechenov First Moscow State Medical University

Application of fat cells in plastic surgery

Authors:

Manturova N.E., Stupin V.A., Orlova A.S., Silina E.V.

More about the authors

Read: 3750 times


To cite this article:

Manturova NE, Stupin VA, Orlova AS, Silina EV. Application of fat cells in plastic surgery. Plastic Surgery and Aesthetic Medicine. 2020;(3):76‑83. (In Russ.)
https://doi.org/10.17116/plast.hirurgia202003176

Recommended articles:
Aesthetic analysis of the face in modern plastic surgery. Plastic Surgery and Aesthetic Medi­cine. 2025;(3-2):64-70
Trunk muscles for flap reco­nstruction in plastic surgeries: a narrative review. Plastic Surgery and Aesthetic Medi­cine. 2025;(3-2):110-118

References:

  1. Matarasso A, Nikfarjam J, Abramowitz L. Incorporating Minimally Invasive Procedures into an Aesthetic Surgery Practice. Clin Plast Surg. 2016; 43(3):449-457.  https://doi.org/10.1016/j.cps.2016.03.001
  2. ASPS. Plastic surgery statistics 2017. Accessed June 14, 2019. https://www.plasticsurgery.org/documents/News/Statistics/2017/plastic-surgery-statistics-report-2017.pdf.
  3. Hammond SE, Samuels S, Thaller S. Filling in the Details: A Review of Lipofilling of Radiated Tissues in the Head and Neck. J Craniofac Surg. 2019; 30(3):667-671.  https://doi.org/10.1097/SCS.0000000000005107
  4. Conlon CJ, Abu-Ghname A, Davis MJ, Ali K, Winocour SJ, Eisemann ML, Winocour J. Fat Grafting for Hand Rejuvenation. Semin Plast Surg. 2020; 34(1):47-52.  https://doi.org/10.1055/s-0039-1700960
  5. Khouri RK, Rigotti G, Cardoso E, Khouri RK Jr, Biggs TM. Megavolume autologous fat transfer: part I. Theory and principles. Plast Reconstr Surg. 2014;133(3):550-557.  https://doi.org/10.1097/01.prs.0000438044.06387.2a
  6. Davis MJ, Perdanasari AT, Abu-Ghname A, Gonzalez SR, Chamata E, Rammos CK, Winocour SJ. Application of Fat Grafting in Cosmetic Breast Surgery. Semin Plast Surg. 2020;34(1):24-29.  https://doi.org/10.1055/s-0039-1700958
  7. Bertozzi N, Pesce M, Santi P, Raposio E. One-Stage Immediate Breast Reconstruction: A Concise Review. Biomed Res Int. 2017;2017:6486859. https://doi.org/10.1155/2017/6486859
  8. Gardani M, Bertozzi N, Grieco MP, Pesce M, Simonacci F, Santi P, Raposio E. Breast reconstruction with anatomical implants: A review of indications and techniques based on current literature. Ann Med Surg (Lond). 2017;21:96-104.  https://doi.org/10.1016/j.amsu.2017.07.047
  9. Egro FM, Coleman SR, Rubin JP. Fat Grafting for Treatment of Secondary Facial Deformity. Clin Plast Surg. 2020;47(1):147-154.  https://doi.org/10.1016/j.cps.2019.08.011
  10. Grieco M, Grignaffini E, Simonacci F, Raposio E. Analysis of Complications in Postbariatric Abdominoplasty: Our Experience. Plast Surg Int. 2015; 2015:209173. https://doi.org/10.1155/2015/209173
  11. Grignaffini E, Grieco MP, Bertozzi N, Gandolfi M, Palli D, Cinieri FG, Gardani M, Raposio E. Post-bariatric abdominoplasty: our experience. Acta Biomed. 2015;86(3):278-282. 
  12. Grieco M, Grignaffini E, Simonacci F, Di Mascio D, Raposio E. Post-bariatric body contouring: oue experience. Acta Biomed. 2016;87(1):70-75. 
  13. Shim YH, Zhang RH. Literature Review to Optimize the Autologous Fat Transplantation Procedure and Recent Technologies to Improve Graft Viability and Overall Outcome: A Systematic and Retrospective Analytic Approach. Aesthetic Plast Surg. 2017;41(4):815-831.  https://doi.org/10.1007/s00266-017-0793-3
  14. Vinaixa C, Selzner N, Berenguer M. Fat and liver transplantation: clinical implications. Transpl Int. 2018;31(8):828-837.  https://doi.org/10.1111/tri.13288
  15. Eto H, Suga H, Matsumoto D, Inoue K, Aoi N, Kato H, Araki J, Yoshimura K. Characterization of structure and cellular components of aspirated and excised adipose tissue. Plast Reconstr Surg. 2009;124:1087-1097.
  16. Mashiko T, Yoshimura K. How does fat survive and remodel after grafting? Clin Plast Surg. 2015;42(2):181-190.  https://doi.org/10.1016/j.cps.2014.12.008
  17. Ogura F, Wakao S, Kuroda Y, Tsuchiyama K, Bagheri M, Heneidi S, Chazenbalk G, Aiba S, Dezawa M. Human adipose tissue possesses a unique population of pluripotent stem cells with nontumorigenic and low telomerase activities: potential implications in regenerative medicine. Stem Cells Dev. 2014;23:717-728. 
  18. Ferraro GA, De Francesco F, Tirino V, Cataldo C, Rossano F, Nicoletti G, D’Andrea F. Effects of a new centrifugation method on adipose cell viability for autologous fat grafting. Aesthetic Plast Surg. 2011;35(3):341-348.  https://doi.org/10.1007/s00266-010-9613-8
  19. Kakagia D, Pallua N. Autologous fat grafting: in search of the optimal technique. Surg Innov. 2014;21(3):327-336.  https://doi.org/10.1177/1553350613518846
  20. Pu LL, Coleman SR, Cui X, Ferguson RE Jr, Vasconez HC. Autologous fat grafts harvested and refined by the Coleman technique: a comparative study. Plast Reconstr Surg. 2008;122(3):932-937.  https://doi.org/10.1097/PRS.0b013e3181811ff0
  21. Xue EY, Narvaez L, Chu CK, Hanson SE. Fat Processing Techniques. Semin Plast Surg. 2020;34(1):11-16.  https://doi.org/10.1055/s-0039-3402052
  22. Fagrell D, Eneström S, Berggren A, Kniola B. Fat cylinder ransplantation: an experimental comparative study of three different kinds of fat transplants. Plast Reconstr Surg. 1996;98(1):90-96. 
  23. Qin W, Xu Y, Liu X, Xu S. Experimental and primary clinical research of core fat graft. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2012;26(5): 576-582. 
  24. Pu LL, Cui X, Fink BF, Cibull ML, Gao D. The viability of fatty tissues within adipose aspirates after conventional liposuction: a comprehensive study. Ann Plast Surg. 2005;54(3):288-292. 
  25. Coleman SR. Structural fat grafting: more than a permanent filler. Plast Reconstr Surg. 2006;118(3 Suppl):108-120. 
  26. Crawford JL, Hubbard BA, Colbert SH, Puckett CL. Fine tuning lipoaspirate viability for fat grafting. Plast Reconstr Surg. 2010;126(4):1342-1348. https://doi.org/10.1097/PRS.0b013e3181ea44a9
  27. Klein JA. Tumescent technique for local anesthesia improves safety in largevolume liposuction. Plast Reconstr Surg. 1993;92(6):1085-1098.
  28. Kasem A, Wazir U, Headon H, Mokbel K. Breast lipofilling: a review of current practice. Arch Plast Surg. 2015;42(2):126-130.  https://doi.org/10.5999/aps.2015.42.2.126
  29. Truzzi GM, Pauna HF, Bette P, Gusmão RJ, Crespo AN, Semenzati GO. Methods of Fat Tissue Processing for Human Vocal Fold Injection: A Systematic Review. J Voice. 2017;31(2):244.e17-244.e21.  https://doi.org/10.1016/j.jvoice.2016.08.012
  30. Mojallal A, Foyatier JL. The effect of different factors on the survival of transplanted adipocytes. Ann Chir Plast Esthet. 2004;49(5):426-436. 
  31. Sommer B, Sattler G. Current concepts of fat graft survival: histology of aspirated adipose tissue and review of the literature. Dermatol Surg. 2000; 26(12):1159-1166.
  32. Condé-Green A, Wu I, Graham I, Chae JJ, Drachenberg CB, Singh DP, Holton L 3rd, Slezak S, Elisseeff J. Comparison of 3 techniques of fat grafting and cell-supplemented lipotransfer in athymic rats: a pilot study. Aesthet Surg J. 2013;33(5):713-721.  https://doi.org/10.1177/1090820X13487371
  33. Strong AL, Cederna PS, Rubin JP, Coleman SR, Levi B. The current state of fat grafting: a review of harvesting, processing, and injection techniques. Plast Reconstr Surg. 2015;136(4):897-912.  https://doi.org/10.1097/PRS.0000000000001590
  34. Pfaff M, Wu W, Zellner E, Steinbacher DM. Processing technique for lipofilling influences adipose-derived stem cell concentration and cell viability in lipoaspirate. Aesthetic Plast Surg. 2014;38(1):224-229.  https://doi.org/10.1007/s00266-013-0261-7
  35. Hoareau L, Bencharif K, Girard AC, Gence L, Delarue P, Hulard O, Festy F, Roche R. Effect of centrifugation and washing on adipose graft viability: a new method to improve graft efficiency. J Plast Reconstr Aesthet Surg. 2013;66(5):712-719.  https://doi.org/10.1016/j.bjps.2012.12.033
  36. Obagi S, Willis C. Autologous Fat Augmentation of the Face. Atlas Oral Maxillofac Surg Clin North Am. 2018;26(1):41-50.  https://doi.org/10.1016/j.cxom.2017.10.004
  37. Tuin AJ, Domerchie PN, Schepers RH, Willemsen JC, Dijkstra PU, Spijkervet FK, Vissink A, Jansma J. What is the current optimal fat grafting processing technique? A systematic review. J Craniomaxillofac Surg. 2016;44(1): 45-55.  https://doi.org/10.1016/j.jcms.2015.10.021
  38. Wilson A, Butler PE, Seifalian AM. Adipose-derived stem cells for clinical applications: a review. Cell Prolif. 2011;44(1):86-98.  https://doi.org/10.1111/j.1365-2184.2010.00736.x
  39. Eto H, Kato H, Suga H, Aoi N, Doi K, Kuno S, Yoshimura K. The fate of adipocytes after nonvascularized fat grafting: evidence of early death and replacement of adipocytes. Plast Reconstr Surg. 2012;129:1081-1092.
  40. Eto H, Suga H, Inoue K, Aoi N, Kato H, Araki J, Doi K, Higashino T, Yoshimura K. Adipose injury-associated factors activate adipose stem/stromal cells, induce neoangiogenesis, and mitigate hypoxia in ischemic tissues. Am J Pathol. 2011;178(5):2322-2332.
  41. Kato H, Mineda K, Eto H, Doi K, Kuno S, Kinoshita K, Kanayama K, Yoshimura K. Degeneration, regeneration, and cicatrization after fat grafting: dynamic total tissue remodeling during the first 3 months. Plast Reconstr Surg. 2014;133:303-313. 
  42. Manturova NE, Smirnova GO, Silina EV, Suzdaltseva YG, Stupin VA. The effectiveness of mesotherapy with progenitor cells of involutional changes in facial skin in patients of different ages. Annals of Tropical Medicine and Public Health. 2018;9(Special Issue):S614. Accessed May 24, 2020. https://www.scopus.com/inward/record.url?eid=2-s2.0-85066620278&partnerID=MN8TOARS
  43. Le Louarn C. Midface region: functional anatomy, ageing process, indications and concentric malar lift. Ann Chir Plast Esthet. 2009;54(5):411-420.  https://doi.org/10.1016/j.anplas.2009.04.003
  44. Rohrich RJ, Arbique GM, Wong C, Brown S, Pessa JE. The anatomy of suborbicularis fat: implications for periorbital rejuvenation. Plast Reconstr Surg. 2009;124(3):946-951.  https://doi.org/10.1097/PRS.0b013e3181b17b76
  45. Siah WF, Litwin AS, Nduka C, Malhotra R. Periorbital Autologous Fat Grafting in Facial Nerve Palsy. Ophthalmic Plast Reconstr Surg. 2017;33(3): 202-208.  https://doi.org/10.1097/IOP.0000000000000710
  46. Serra-Renom JM, Serra-Mestre JM. Periorbital rejuvenation to improve the negative vector with blepharoplasty and fat grafting in the malar area. Ophthalmic Plast Reconstr Surg. 2011;27(6):442-446.  https://doi.org/10.1097/IOP.0b013e318224b0d5
  47. Schultz KP, Raghuram A, Davis MJ, Abu-Ghname A, Chamata E, Rohrich RJ. Fat Grafting for Facial Rejuvenation. Semin Plast Surg. 2020;34(1):30-37.  https://doi.org/10.1055/s-0039-3402767
  48. Boureaux E, Chaput B, Bannani S, Herlin C, De Runz A, Carloni R, Mortemousque B, Mouriaux F, Watier E, Bertheuil N. Eyelid fat grafting: indications, operative technique and complications; a systematic review. J Craniomaxillofac Surg. 2016;44(4):374-380.  https://doi.org/10.1016/j.jcms.2015.12.013
  49. Hoang D, Orgel MI, Kulber DA. Hand rejuvenation: a comprehensive review of fat grafting. J Hand Surg Am. 2016;41(5):639-644.  https://doi.org/10.1016/j.jhsa.2016.03.006
  50. Fabi SG, Goldman MP. Hand rejuvenation: our experience. Dermatol Surg. 2012;38(7Pt2):1112-1127. https://doi.org/10.1111/j.1524-4725.2011.02291.x
  51. Streker M, Reuther T, Krueger N, Kerscher M. Stabilized hyaluronic acid-based gel of non-animal origin for skin rejuvenation: face, hand, and décolletage. J Drugs Dermatol. 2013;12(9):990-994. 
  52. Brandt FS, Cazzaniga A, Strangman N, Coleman J, Axford-Gatley R. Longterm effectiveness and safety of small gel particle hyaluronic acid for hand rejuvenation. Dermatol Surg. 2012;38(7Pt2):1128-1135. https://doi.org/10.1111/j.1524-4725.2011.02282.x
  53. Kao WP, Lin YN, Lin TY, Huang YH, Chou CK, Takahashi H, Shieh TY, Chang KP, Lee SS, Lai CS, Lin SD, Lin TM. Microautologous fat transplantation for primary augmentation rhinoplasty: long-term monitoring of 198 Asian patients. Aesthet Surg J. 2016;36(6):648-656.  https://doi.org/10.1093/asj/sjv253
  54. Pu LL, Yoshimura K, Coleman SR. Future perspectives of fat grafting. Clin Plast Surg. 2015;42(3):389-394.  https://doi.org/10.1016/j.cps.2015.03.007
  55. Turner A, Abu-Ghname A, Davis MJ, Winocour SJ, Hanson SE, Chu CK. Fat Grafting in Breast Reconstruction. Semin Plast Surg. 2020;34(1):17-23.  https://doi.org/10.1055/s-0039-1700959
  56. Villani F, Caviggioli F, Giannasi S, Klinger M, Klinger F. Current applications and safety of autologous fat grafts: a report of the ASPS Fat Graft Task Force. Plast Reconstr Surg. 2010;125(2):758-759.  https://doi.org/10.1097/PRS.0b013e3181c722cf
  57. Kling RE, Mehrara BJ, Pusic AL, Young VL, Hume KM, Crotty CA, Rubin JP. Trends in autologous fat grafting to the breast: a national survey of the American Society of Plastic Surgeons. Plast Reconstr Surg. 2013;132(1): 35-46.  https://doi.org/10.1097/PRS.0b013e318290fad1
  58. O’Neill RC, Abu-Ghname A, Davis MJ, Chamata E, Rammos CK, Winocour SJ. The Role of Fat Grafting in Buttock Augmentation. Semin Plast Surg. 2020;34(1):38-46.  https://doi.org/10.1055/s-0039-3401038
  59. Veber M, Tourasse C, Toussoun G, Moutran M, Mojallal A, Delay E. Radiographic findings after breast augmentation by autologous fat transfer. Plast Reconstr Surg. 2011;127(3):1289-1299. https://doi.org/10.1097/PRS.0b013e318205f38f
  60. Claudio Silva-Vergara C, Fontdevila J, Weshahy O. Fat Grafting Technique, A Paradigm Shift in the Treatment of Tuberous Breast. World J Plast Surg. 2018;7(1):72-77. 
  61. Cárdenas-Camarena L, Arenas-Quintana R, Robles-Cervantes JA. Buttocks fat grafting: 14 years of evolution and experience. Plast Reconstr Surg. 2011; 128(2):545-555.  https://doi.org/10.1097/PRS.0b013e31821b640b
  62. Doornaert M, Colle J, De Maere E, Declercq H, Blondeel P. Autologous fat grafting: Latest insights. Ann Med Surg (Lond). 2018;37:47-53.  https://doi.org/10.1016/j.amsu.2018.10.016
  63. Peltoniemi HH, Salmi A, Miettinen S, Mannerström B, Saariniemi K, Mikkonen R, Kuokkanen H, Herold C. Stem cell enrichment does not warrant a higher graft survival in lipofilling of the breast: a prospective comparative study. J Plast Reconstr Aesthet Surg. 2013;66(11):1494-1503. https://doi.org/10.1016/j.bjps.2013.06.002
  64. Smith P, Adams WP Jr, Lipschitz AH, Chau B, Sorokin E, Rohrich RJ, Brown SA. Autologous human fat grafting: effect of harvesting and preparation techniques on adipocyte graft survival. Plast Reconstr Surg. 2006;117(6): 1836-1844.
  65. Al Sufyani MA, Al Hargan AH, Al Shammari NA, Al Sufyani MA. Autologous Fat Transfer for Breast Augmentation: A Review. Dermatol Surg. 2016; 42(11):1235-1242.
  66. Gigli S, Amabile MI, DI Pastena F, DE Luca A, Gulia C, Manganaro L, Monti M, Ballesio L. Lipofilling Outcomes Mimicking Breast Cancer Recurrence: Case Report and Update of the Literature. Anticancer Res. 2017; 37(10):5395-5398.
  67. Agha RA, Fowler AJ, Pidgeon TE, Wellstead G, Orgill DP; VOGUE Steering Group. Use of autologous fat grafting for breast reconstruction: a systematic review with metaanalysis of oncological outcomes. Int J Surg. 2016; 31:104-106.  https://doi.org/10.1016/j.ijsu.2016.05.067
  68. Pavlidis L, Sapountzis S, Spyropoulou GA, Demiri E. Fat grafting to the hand in patients with raynaud phenomenon: a novel therapeutic modality. Plast Reconstr Surg. 2015;135(1):229e-330e. https://doi.org/10.1097/PRS.000000000000814
  69. Butterwick KJ. Rejuvenation of the aging hand. Dermatol Clin. 2005;23(3): 515-527. 
  70. Vara AD, Miki RA, Alfonso DT, Cardoso R. Hand fat grafting complicated by abscess. Hand (NY). 2013;8(3):348-351.  https://doi.org/10.1007/s11552-013-9508-7
  71. Park SH, Sun HJ, Choi KS. Sudden unilateral visual loss after autologous fat injection into the nasolabial fold. Clin Ophthalmol. 2008;2(3):679-683. 
  72. Gupta R, Brace M, Taylor SM, Bezuhly M, Hong P. In search of the optimal processing technique for fat grafting. J Craniofac Surg. 2015;26(1):94-99.  https://doi.org/10.1097/SCS.0000000000001259
  73. Tabit CJ, Slack GC, Fan K, Wan DC, Bradley JP. Fat grafting versus adipose-derived stem cell therapy: distinguishing indications, techniques, and outcomes. Aesthetic Plast Surg. 2012;36:704-713. 
  74. Chung MT, Hyun JS, Lo DD, Montoro DT, Hasegawa M, Levi B, Januszyk M, Longaker MT, Wan DC. Micro-computed tomography evaluation of human fat grafts in nude mice. Tissue Eng Part C Methods. 2013;19:227-232. 

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.