Cell therapy in the treatment of non-healing trophic ulcers of the lower extremities

Gilevich I.V.

Research Institution — Regional Clinical Hospital No.1

Shubrov E.N.

Research Institution — Regional Clinical Hospital No.1

Bogdanov S.B.

Kuban State Medical University;
Research Institute — Ochapovsky Regional Clinical Hospital No. 1

Fedyushkin V.V.

Research Institution — Regional Clinical Hospital No.1

Kolomiytseva E.A.

Research Institution — Regional Clinical Hospital No.1

Shubrova V.V.

Research Institution — Regional Clinical Hospital No.1

Cell therapy in the treatment of non-healing trophic ulcers of the lower extremities

Authors:

Gilevich I.V., Shubrov E.N., Bogdanov S.B., Fedyushkin V.V., Kolomiytseva E.A., Shubrova V.V.

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Journal: Plastic Surgery and Aesthetic Medicine. 2020;(3): 53‑59

DOI: 10.17116/plast.hirurgia202003153

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To cite this article:

Gilevich IV, Shubrov EN, Bogdanov SB, Fedyushkin VV, Kolomiytseva EA, Shubrova VV. Cell therapy in the treatment of non-healing trophic ulcers of the lower extremities. Plastic Surgery and Aesthetic Medicine. 2020;(3):53‑59. (In Russ.)
https://doi.org/10.17116/plast.hirurgia202003153

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OBJECTIVE

To evaluate the effectiveness of allogeneic fibroblasts in the treatment of chronic trophic ulcers of the lower extremities.

MATERIAL AND METHODS

Treatment of 3 patients with chronic ulcers of lower extremities was analyzed. Allogeneic fibroblasts were obtained from the cell bank.

RESULTS

Allogeneic fibroblasts improved the engraftment of an autologous skin graft in patients with large trophic ulcers of the lower extremities after previous unsuccessful standard therapy including vacuum therapy. Skin autoplasty was failed too. Allogeneic fibroblasts were used before plastic closure of the wound with a split-thickness skin autograft. Complete adaptation of the skin graft was observed after 14—15 days. Thus, this technique made it possible to reduce the time of graft healing by 5—7 days. In one case, skin autoplasty with partial adaptation of the flap and formation of several skin fistulous pathways were performed with high risk of limb amputation. Application of allogeneic fibroblasts ensured wound healing and preservation of the remaining skin flap. No amputations were required.

CONCLUSION

Allogeneic human fibroblasts together with autologous dermoplasty stimulates epithelization and reduces the risk of complications in patients with chronic ulcers of lower extremities.

Keywords:

trophic ulcer

autodermoplasty

dermal fibroblasts

cell therapy

Authors:

Gilevich I.V.

Research Institution — Regional Clinical Hospital No.1

Shubrov E.N.

Research Institution — Regional Clinical Hospital No.1

Bogdanov S.B.

Kuban State Medical University;
Research Institute — Ochapovsky Regional Clinical Hospital No. 1

Fedyushkin V.V.

Research Institution — Regional Clinical Hospital No.1

Kolomiytseva E.A.

Research Institution — Regional Clinical Hospital No.1

Shubrova V.V.

Research Institution — Regional Clinical Hospital No.1

Received:

17.05.2020

Accepted:

27.05.2020

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