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Karpova E.I.

FGUZ "Klinicheskaia bol'nitsa #119" FMBA Rossii, Khimki

Potekaev N.N.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology, Moscow, Russia

Murakov S.V.

V.G. Korolenko City Clinical Hospital 14, Moscow

Danishchuk O.I.

FGUZ Klinicheskaia bol'nitsa # 119 FMBA Rossii, Khimki

Demina O.M.

FUV GBOU VPO RNIMU im. N.I. Pirogova Minzdrava Rossii, Moskva

Complications of dermal fillers injection in facial augmentation: international and Russian experience

Authors:

Karpova E.I., Potekaev N.N., Murakov S.V., Danishchuk O.I., Demina O.M.

More about the authors

Journal: Plastic Surgery and Aesthetic Medicine. 2019;(4): 54‑75

DOI: 10.17116/plast.hirurgia201904154

Views: 82077

Downloaded: 4667

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COMPLICATIONS OF DERMAL FILLERS INJECTION IN FACIAL AUGMENTATION: INTERNATIONAL AND RUSSIAN EXPERIENCE
COMPLICATIONS OF DERMAL FILLERS INJECTION IN FACIAL AUGMENTATION: INTERNATIONAL AND RUSSIAN EXPERIENCE

To cite this article:

Karpova EI, Potekaev NN, Murakov SV, Danishchuk OI, Demina OM. Complications of dermal fillers injection in facial augmentation: international and Russian experience. Plastic Surgery and Aesthetic Medicine. 2019;(4):54‑75. (In Russ.)
https://doi.org/10.17116/plast.hirurgia201904154

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Beginning of new millennium was designated by expansion of non-invasive esthetic surgery in Russian region. Use of dermal fillers for facial augmentation is now recognized as one of the most popular procedures. Emerging production technologies led to declining rates of some dermal fillers use complications. Meanwhile growing rates of facial fillers use made doctors encounter more adverse reactions. Present article describes possible complications of facial augmentation with hyaluronic acid dermal fillers, ways of diagnostics, treatment and prevention. Authors also share their own experience in esthetic medicine and hyaluronic acid fillers use.

Keywords:

facial augmentation
dermal fillers
hyaluronic acid
Juvederm

Authors:

Karpova E.I.

FGUZ "Klinicheskaia bol'nitsa #119" FMBA Rossii, Khimki

Potekaev N.N.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology, Moscow, Russia

Murakov S.V.

V.G. Korolenko City Clinical Hospital 14, Moscow

Danishchuk O.I.

FGUZ Klinicheskaia bol'nitsa # 119 FMBA Rossii, Khimki

Demina O.M.

FUV GBOU VPO RNIMU im. N.I. Pirogova Minzdrava Rossii, Moskva

List of references:

  1. Klein AW, Elson ML. The History of Substances for Soft Tissue Augmentation. Dermatologic Surgery. 2000;26(12):1096-1105. https://doi.org/10.1046/j.1524-4725.2000.00512.x
  2. Monheit G, Beer K, Hardas B, et al. Safety and Effectiveness of the Hyaluronic Acid Dermal Filler VYC-17.5L for Nasolabial Folds: Results of a Randomized, Controlled Study. Dermatol Surg. 2018;44(5):670-678. https://doi.org/10.1097/DSS.0000000000001529
  3. Rivkin A, Weinkle SH, Hardas B, et al. Safety and Effectiveness of Repeat Treatment With VYC-15L for Lip and Perioral Enhancement: Results From a Prospective Multicenter Study. Aesthetic Surgery Journal. 2018 January. https://doi.org/10.1093/asjour/sjy019
  4. Stojanovič L, Majdič N. Effectiveness and safety of hyaluronic acid fillers used to enhance overall lip fullness: A systematic review of clinical studies. J Cosmet Dermatol. 2019;18(2):436-443. https://doi.org/10.1111/jocd.12861
  5. Nusgens BV. Acide hyaluronique et matrice extracellulaire : une molécule primitive ? Annales de Dermatologie et de Vénéréologie. 2010;137:S3-S8. https://doi.org/10.1016/S0151-9638(10)70002-8
  6. Ascher B, Cerceau M, Baspeyras M, Rossi B. Les comblements par l’acide hyaluronique. Annales de Chirurgie Plastique Esthétique. 2004;49(5):465-485. https://doi.org/10.1016/j.anplas.2004.09.001
  7. Fraser JRE, Laurent TC, Laurent UBG. Hyaluronan: its nature, distribution, functions and turnover. Journal of Internal Medicine. 1997;242(1):27-33. https://doi.org/10.1046/j.1365-2796.1997.00170.x
  8. Fraser JR, Dahl LB, Kimpton WG, Cahill RN, Brown TJ, Vakakis N. Elimination and subsequent metabolism of circulating hyaluronic acid in the fetus. J Dev Physiol. 1989;11(4):235-242.
  9. Fraser JR, Laurent TC. Turnover and metabolism of hyaluronan. Ciba Found Symp. 1989;143:41-53;discussion 53-59, 281-285.
  10. Laurent TC. Biochemistry of Hyaluronan. Acta Oto-Laryngologica. 1987; 104(sup442):7-24. https://doi.org/10.3109/00016488709102833
  11. Laurent TC, Dahl IMS, Dahl LB, et al. The Catabolic Fate of Hyaluronic Acid. Connective Tissue Research. 1986;15(1-2):33-41. https://doi.org/10.3109/03008208609001971
  12. Fraser JRE, Laurent TC, Engström-Laurent A, Laurent UGB. Elimination of hyaluronic acid from the blood stream in the human. Clin Exp Pharmacol Physiol. 1984;11(1):17-25. https://doi.org/10.1111/j.1440-1681.1984.tb00235.x
  13. Urdiales-Gálvez F, Delgado NE, Figueiredo V, et al. Treatment of Soft Tissue Filler Complications: Expert Consensus Recommendations. Aesth Plast Surg. 2018;42(2):498-510. https://doi.org/10.1007/s00266-017-1063-0
  14. Alam M, Dover JS. Management of Complications and Sequelae with Temporary Injectable Fillers. Plastic and Reconstructive Surgery. 2007;120(Supplement): 98S-105S. https://doi.org/10.1097/01.prs.0000248859.14788.60
  15. Pavicic T, Funt D. Dermal fillers in aesthetics: an overview of adverse events and treatment approaches. CCID. 2013 December;295. https://doi.org/10.2147/CCID.S50546
  16. Vedamurthy M. Beware what you inject: Complications of injectables—dermal fillers. J Cutan Aesthet Surg. 2018;11(2):60. https://doi.org/10.4103/JCAS.JCAS_68_18
  17. Lemperle G, Rullan PP, Gauthier-Hazan N. Avoiding and Treating Dermal Filler Complications. Plastic and Reconstructive Surgery. 2006;118(Suppl): 92S-107S. https://doi.org/10.1097/01.prs.0000234672.69287.77
  18. Bailey SH, Cohen JL, Kenkel JM. Etiology, Prevention, and Treatment of Dermal Filler Complications. Aesthetic Surgery Journal. 2011;31(1):110-121. https://doi.org/10.1177/1090820X10391083
  19. De Boulle K, Heydenrych I. Patient factors influencing dermal filler complications: prevention, assessment, and treatment. CCID. 2015 April;205. https://doi.org/10.2147/CCID.S80446
  20. Funt D, Pavicic T. Dermal Fillers in Aesthetics: An Overview of Adverse Events and Treatment Approaches. Plastic Surgical Nursing. 2015;35(1):13-32. https://doi.org/10.1097/PSN.0000000000000087
  21. DeLorenzi C. Complications of Injectable Fillers, Part 2: Vascular Complications. Aesthetic Surgery Journal. 2014;34(4):584-600. https://doi.org/10.1177/1090820X14525035
  22. DeLorenzi C. Complications of Injectable Fillers, Part I. Aesthetic Surgery Journal. 2013;33(4):561-575. https://doi.org/10.1177/1090820X13484492
  23. Fitzgerald R, Bertucci V, Sykes J, Duplechain J. Adverse Reactions to Injectable Fillers. Facial Plast Surg. 2016;32(05):532-555. https://doi.org/10.1055/s-0036-1592340
  24. Signorini M, Liew S, Sundaram H, et al. Global Aesthetics Consensus: Avoidance and Management of Complications from Hyaluronic Acid Fillers—Evidence- and Opinion-Based Review and Consensus Recommendations. Plastic and Reconstructive Surgery. 2016;137(6):961e-971e. https://doi.org/10.1097/PRS.0000000000002184
  25. Glass GE, Tzafetta K. Optimising treatment of Bell’s Palsy in primary care: the need for early appropriate referral. Br J Gen Pract. 2014;64(629):e807-e809. https://doi.org/10.3399/bjgp14X683041
  26. Park SW, Woo SJ, Park KH, Huh JW, Jung C, Kwon O-K. Iatrogenic Retinal Artery Occlusion Caused by Cosmetic Facial Filler Injections. American Journal of Ophthalmology. 2012;154(4):653-662.e1. https://doi.org/10.1016/j.ajo.2012.04.019
  27. Cassuto D, Marangoni O, De Santis G, Christensen L. Advanced Laser Techniques for Filler-Induced Complications. Dermatologic Surgery. 2009;35:1689-1695. https://doi.org/10.1111/j.1524-4725.2009.01348.x
  28. Cox SE. Clinical Experience With Filler Complications. Dermatologic Surgery. 2009;35:1661-1666. https://doi.org/10.1111/j.1524-4725.2009.01345.x
  29. Rzany B, Becker-Wegerich P, Bachmann F, Erdmann R, Wollina U. Hyaluronidase in the correction of hyaluronic acid-based fillers: a review and a recommendation for use. Journal of Cosmetic Dermatology. 2009;8(4):317-323. https://doi.org/10.1111/j.1473-2165.2009.00462.x
  30. Griepentrog GJ, Lucarelli MJ, Burkat CN, Lemke BN, Rose JG. Periorbital Edema following Hyaluronic Acid Gel Injection: A Retrospective Review. Am J Cosmet Surg. 2011;28(4):251-254. https://doi.org/10.1177/074880681102800408
  31. Rohrich RJ, Monheit G, Nguyen AT, Brown SA, Fagien S. Soft Tissue Filler Complications: The important role of biofilms. Plastic and Reconstructive Surgery. 2010 January1. https://doi.org/10.1097/PRS.0b013e3181cb4620
  32. Costerton JW. Bacterial Biofilms: A Common Cause of Persistent Infections. Science. 1999;284(5418):1318-1322. https://doi.org/10.1126/science.284.5418.1318
  33. Shiau A, Wu C. The Inhibitory Effect of Staphylococcus epidermidis Slime on the Phagocytosis of Murine Peritoneal Macrophages Is Interferon-Independent. Microbiology and Immunology. 1998;42(1):33-40. https://doi.org/10.1111/j.1348-0421.1998.tb01966.x
  34. Singh R, Ray P, Das A, Sharma M. Role of persisters and small-colony variants in antibiotic resistance of planktonic and biofilm-associated Staphylococcus aureus: an in vitro study. Journal of Medical Microbiology. 2009;58(8):1067-1073. https://doi.org/10.1099/jmm.0.009720-0
  35. Flemming HC. Biofouling in water systems — cases, causes and countermeasures. Appl Microbiol Biotechnol. 2002;59(6):629-640. https://doi.org/10.1007/s00253-002-1066-9
  36. Monheit GD, Rohrich RJ. The Nature of Long-Term Fillers and the Risk of Complications. Dermatologic Surgery. 2009;35:1598-1604. https://doi.org/10.1111/j.1524-4725.2009.01336.x
  37. Wagner R, Fakhro A, Cox J, Izaddoost S. Etiology, Prevention, and Management of Infectious Complications of Dermal Fillers. Seminars in Plastic Surgery. 2016;30(02):083-086. https://doi.org/10.1055/s-0036-1580734
  38. Beer K, Avelar R. Relationship Between Delayed Reactions to Dermal Fillers and Biofilms: Facts and Considerations. Dermatologic Surgery. 2014;40(11):1175-1179. https://doi.org/10.1097/01.DSS.0000452646.76270.53
  39. Bjarnsholt T, Tolker-Nielsen T, Givskov M, Janssen M, Christensen LH. Detection of Bacteria by Fluorescence in Situ Hybridization in Culture-Negative Soft Tissue Filler Lesions. Dermatologic Surgery. 2009;35:1620-1624. https://doi.org/10.1111/j.1524-4725.2009.01313.x
  40. Hou W, Sun X, Wang Z, Zhang Y. Biofilm-Forming Capacity of Staphylococcus epidermidis , Staphylococcus aureus , and Pseudomonas aeruginosa from Ocular Infections. Invest Ophthalmol Vis Sci. 2012;53(9):5624. https://doi.org/10.1167/iovs.11-9114
  41. Golińska E. Virulence factors of Enterococcus strains isolated from patients with inflammatory bowel disease. WJG. 2013;19(23):3562. https://doi.org/10.3748/wjg.v19.i23.3562
  42. Walker TJ, Toriumi DM. Analysis of Facial Implants for Bacterial Biofilm Formation Using Scanning Electron Microscopy. JAMA Facial Plast Surg. 2016;18(4):299. https://doi.org/10.1001/jamafacial.2016.0279
  43. Cassuto D, Sundaram H. A Problem-Oriented Approach to Nodular Complications from Hyaluronic Acid and Calcium Hydroxylapatite Fillers: Classification and Recommendations for Treatment. Plastic and Reconstructive Surgery. 2013;132:48S-58S. https://doi.org/10.1097/PRS.0b013e31829e52a7
  44. Hoffmann N, Lee B, Hentzer M, et al. Azithromycin Blocks Quorum Sensing and Alginate Polymer Formation and Increases the Sensitivity to Serum and Stationary-Growth-Phase Killing of Pseudomonas aeruginosa and Attenuates Chronic P. aeruginosa Lung Infection in Cftr/Mice. Antimicrobial Agents and Chemotherapy. 2007;51(10):3677-3687. https://doi.org/10.1128/AAC.01011-06
  45. Rzany B, DeLorenzi C. Understanding, Avoiding, and Managing Severe Filler Complications. Plastic and Reconstructive Surgery. 2015;136:196S-203S. https://doi.org/10.1097/PRS.0000000000001760
  46. Lemperle G, Gauthier-Hazan N, Wolters M, Eisemann-Klein M, Zimmermann U, Duffy DM. Foreign Body Granulomas after All Injectable Dermal Fillers: Part 1. Possible Causes. Plastic and Reconstructive Surgery. 2009;123(6):1842-1863. https://doi.org/10.1097/PRS.0b013e31818236d7
  47. Lemperle G, Gauthier-Hazan N. Foreign Body Granulomas after All Injectable Dermal Fillers: Part 2. Treatment Options. Plastic and Reconstructive Surgery. 2009;123(6):1864-1873. https://doi.org/10.1097/PRS.0b013e3181858f4f
  48. Rousso JJ, Pitman MJ. Enterococcus faecalis Complicating Dermal Filler Injection: A Case of Virulent Facial Abscesses. Dermatologic Surgery. 2010;36(10):1638-1641. https://doi.org/10.1111/j.1524-4725.2010.01699.x
  49. Heydenrych I, Kapoor KM, De Boulle K, et al. A 10-point plan for avoiding hyaluronic acid dermal filler-related complications during facial aesthetic procedures and algorithms for management. CCID. 2018;11:603-611. https://doi.org/10.2147/CCID.S180904
  50. Hee CK, Shumate GT, Narurkar V, Bernardin A, Messina DJ. Rheological Properties and In Vivo Performance Characteristics of Soft Tissue Fillers. Dermatologic Surgery. 2015;41:S373-S381. https://doi.org/10.1097/DSS.0000000000000536
  51. Few J, Cox SE, Paradkar-Mitragotri D, Murphy DK. A Multicenter, Single-Blind Randomized, Controlled Study of a Volumizing Hyaluronic Acid Filler for Midface Volume Deficit: Patient-Reported Outcomes at 2 Years. Aesthet Surg J. 2015;35(5):589-599. https://doi.org/10.1093/asj/sjv050
  52. Dayan S, Maas CS, Grimes PE, et al. Safety and Effectiveness of VYC-17.5L for Long-term Correction of Nasolabial Folds. Aesthetic Surgery Journal. 2019 July:sjz200. https://doi.org/10.1093/asj/sjz200
  53. Niforos F, Acquilla R, Ogilvie P, et al. A Prospective, Open-Label Study of Hyaluronic Acid-Based Filler With Lidocaine (VYC-15L) Treatment for the Correction of Infraorbital Skin Depressions. Dermatologic Surgery. 2017;43(10):1271-1280. https://doi.org/10.1097/DSS.0000000000001127
  54. De Boulle K, Glogau R, Kono T, et al. A Review of the Metabolism of 1,4-Butanediol Diglycidyl Ether-Crosslinked Hyaluronic Acid Dermal Fillers. Dermatologic Surgery. 2013;39(12):1758-1766. https://doi.org/10.1111/dsu.12301
  55. Allergan Data on File 003: VOLBELLA. Investigation. 2014 Nov.
  56. European Pharmacopeia Monograph number 1472. Accessed on: 10 Oct 2019. Available at: http://www.simpex-inter.ch/data/files/Sodium%20hyaluronate.pdf
  57. Baeva LF, Lyle DB, Rios M, Langone JJ, Lightfoote MM. Different molecular weight hyaluronic acid effects on human macrophage interleukin-1β production: Effects of Lmw+Ha on Human Monocytes. J Biomed Mater Res. 2014;102(2):305-314. https://doi.org/10.1002/jbm.a.34704
  58. Lyle DB, Breger JC, Baeva LF, et al. Low molecular weight hyaluronic acid effects on murine macrophage nitric oxide production. J Biomed Mater Res. 2010;9999A:NA-NA. https://doi.org/10.1002/jbm.a.32760
  59. Hee C, et al. Role of bacteria on the in vitro immune response to hyaluronic acid fillers. Presented at the 76th Annual Meeting of the American Academy of Dermatology. Dermatology (San Diego, CA). 2018 February 16-20.
  60. Dong Y, Arif A, Olsson M, et al. Endotoxin free hyaluronan and hyaluronan fragments do not stimulate TNF-α, interleukin-12 or upregulate co-stimulatory molecules in dendritic cells or macrophages. Sci Rep. 2016;6(1):36928. https://doi.org/10.1038/srep36928
  61. Hilton S, Sattler G, Berg A-K, Samuelson U, Wong C. Randomized, Evaluator-Blinded Study Comparing Safety and Effect of Two Hyaluronic Acid Gels for Lips Enhancement. Dermatologic Surgery. 2018;44(2):261-269. https://doi.org/10.1097/DSS.0000000000001282
  62. Dermal Fillers Approved by the Center for Devices and Radiological Health. Accessed on: 20 Sep 2019. Available at: https://www.fda.gov/medical-devices/cosmetic-devices/dermal-fillers-approved-center-devices-and-radiological-health#approved
  63. Niforos F, Ogilvie P, Cavallini M, et al. VYC-12 Injectable Gel Is Safe And Effective For Improvement Of Facial Skin Topography: A Prospective Study. CCID. 2019;12:791-798. https://doi.org/10.2147/CCID.S216222
  64. Cavallini M, Papagni M, Ryder TJ, Patalano M. Skin Quality Improvement With VYC-12, a New Injectable Hyaluronic Acid: Objective Results Using Digital Analysis. Dermatologic Surgery. 2019 March 1. https://doi.org/10.1097/DSS.0000000000001932
  65. Sattler G, Philipp-Dormston WG, Van Den Elzen H, et al. A Prospective, Open-Label, Observational, Postmarket Study Evaluating VYC-17.5L for the Correction of Moderate to Severe Nasolabial Folds Over 12 Months. Dermatologic Surgery. 2017;43(2):238-245. https://doi.org/10.1097/DSS.0000000000000939

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