The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Lipatov V.A.

Kursk State Medical University

Arlyapov V.A.

Tula State University

Denisov A.A.

Kursk State Medical University

Mishina E.S.

Kursk State Medical University

Kudryavtseva T.N.

Kursk State University

Korelskaya K.A.

Kursk State Medical University

Comparative study of structural properties of polymeric matrixes

Authors:

Lipatov V.A., Arlyapov V.A., Denisov A.A., Mishina E.S., Kudryavtseva T.N., Korelskaya K.A.

More about the authors

Journal: Russian Journal of Operative Surgery and Clinical Anatomy. 2025;9(4): 47‑51

DOI: 10.17116/operhirurg2025904147

Read: 337 times

Buy for 300₽
Contact the author
Table of contents

COMPARATIVE STUDY OF STRUCTURAL PROPERTIES OF POLYMERIC MATRIXES
COMPARATIVE STUDY OF STRUCTURAL PROPERTIES OF POLYMERIC MATRIXES

To cite this article:

Lipatov VA, Arlyapov VA, Denisov AA, Mishina ES, Kudryavtseva TN, Korelskaya KA. Comparative study of structural properties of polymeric matrixes. Russian Journal of Operative Surgery and Clinical Anatomy. 2025;9(4):47‑51. (In Russ.)
https://doi.org/10.17116/operhirurg2025904147

Подписка 2026 Оперативная хирургия и клиническая анатомия (Пироговский научный журнал) (Russian Journal of Operative Surgery and Clinical Anatomy)
МСФ на ЯМ
Использование инфографики авторами научных работ
Recommended articles:
Modern methods of correction of age-related changes in the female body. Plastic Surgery and Aesthetic Medi­cine. 2025;(1):90-96
Implantation and transplantation mate­rials in plastic closure of nasal septum perforation (literature review). Russian Bulletin of Otorhinolaryngology. 2025;(2):55-62
Rege­nerative capa­bilities of platelet-rich plasma in different age groups. Piro­gov Russian Journal of Surgery. 2025;(5):36-43
Connective tissue defi­ciency in the pathogenesis of ante­rior abdo­minal wall hernias and modern diagnostic approaches to improve hernioplasty outcomes. Russian Journal of Evidence-Based Gastroenterology. 2025;(3):86-94
Expe­rience in using rege­nerative technologies in the treatment of patients with nasal septum perforation. Russian Bulletin of Otorhinolaryngology. 2025;(5):35-40
Intraopertive use of local hemo­statics in infe­cted wounds. Piro­gov Russian Journal of Surgery. 2025;(11):94-100
The influence of poly­mer addi­tives in the composition of implantable matrices based on collagen and hyaluronic acid on their degradation in vitro. Stomatology. 2025;(6-2):94-99
Using label-free Raman spectroscopy to quantify matrix-associated aging products in tissues of various organs in an animal model. Plastic Surgery and Aesthetic Medi­cine. 2025;(4):58-62
Morphological analysis of biomaterials obtained through micronization of adipose tissue. Piro­gov Russian Journal of Surgery. 2025;(11-2):38-45
Abstract:

OBJECTIVE

Comparative analysis of the pore diameter and fiber thickness of polymer matrices with an assessment of the possibility of their colonization by cell cultures.

MATERIAL AND METHODS

Porous collagen matrices based on marine collagen (MC GA), (MC GLIO), developed on the basis of KSMU and KSU (Kursk) were used as the study material. Electron microscopy of the samples was carried out with measurements of the pore diameter and fiber thickness.

RESULTS

As a result of the study of the pore diameter, the highest value was found in MC KRS 555.2 [508.7; 602.3] (SEM 19.61) μm, in the MC GLIO group the diameter was 376.1 [204.7; 676.6] (SEM 66.59) µm and in the MC GA group 102.2 [90; 115.4] (SEM 4.445) µm. Statistically significant differences were found between the MC GA and MC GLIO groups (p=0.0032) and between the MC GA and BSE MC groups (p<0.0001). The greatest fiber thickness was found in the MC GA samples 42.25 [35.65; 48.93] (SEM 2.704) µm, in the BSE group 21.2 [17.88; 25.08] (SEM 1.101) µm and in the MC GLIO group 22.1 [17.38; 27.08] (SEM 1.683) µm. Statistically significant differences were found between MC GA and MC GLIO (p=0.0008) and between MC GA and MC BSE (p=0.0002).

CONCLUSION

Thus, the pore diameter of MC BSE is 1.5 times larger than that of MC GLIO and 5.4 times higher than that of MC GA (p≤0.05). The thickness of the matrix fibers of MC GA is 2 times larger than that of BSE and 1.9 times higher than that of MC GLIO (p≤0.05). A comprehensive assessment of these parameters allows us to conclude that the choice of MC GA as a cell culture carrier is the most rational.

Keywords:

tissue engineering constructs
collagen
matrix
surgical materials
regenerative medicine

Authors:

Lipatov V.A.

Kursk State Medical University

Arlyapov V.A.

Tula State University

Denisov A.A.

Kursk State Medical University

Mishina E.S.

Kursk State Medical University

Kudryavtseva T.N.

Kursk State University

Korelskaya K.A.

Kursk State Medical University

Received:

14.04.2025

Accepted:

07.09.2025

Close metadata

References:

  1. Yatsenko AA, Kushnarev VA, Leonov DV, Ustinov EM, Tseluyko SS. Biodegradable properties of porous scaffold of gelatin for use in tissue engineering of lung. Bulletin Physiology and Pathology of Respiration. 2019;72:66-72. (In Russ.).
  2. Sun K, Li H, Li R, Nian Z, Li D, Xu C. Silk fibroin/collagen and silk fibroin/chitosan blended three-dimensional scaffolds for tissue engineering. Eur. J Orthop Surg Traumatol. 2021;25:243-249. 
  3. Efimov AE, Agapova OI, Safonova LA, Bobrova MM, Parfenov VA, Kudan EV, Pereyra FDAS, Bulanova EA, Mironov VA, Agapov II. Nanostructural features of contacts of fibroblasts with dual-scale biocompatible polyurethane scaffold. Russian nanotechnology. 2022; 11-12(11):116-119. (In Russ.).
  4. Kovylin RS, Aleynik DA, Fedyushkin IL. Modern porous polymer implants: production, properties, application. High-molecular-weight compounds. Series S. 2021;1(63):33-53. (In Russ.). https://doi.org/10.31857/S2308114721010039
  5. Gebauer JM, Kobbe B, Paulsson M, Wagener R. Structure, evolution and expression of collagen XXVIII. Lessons from the zebrafish. Matrix Biol. 2015.
  6. Shekhter AB, Gullera E, Istranov LP, Istranova EV, Butnaru DV, Vinarov AZ, Zakharkina OL, Kurkov AV, Kantimerov DF, Antonov EN, Marisov LV, Glybochko PV. Morphology of collagen matrices for tissue engineering (biocompatibility, biodegradation, tissue response). Russian Journal of Archive of Pathology. 2015;6(77):29-38. (In Russ.). https://doi.org/10.17116/patol201577629-38
  7. Sokolova AI, Bobrova MM, Safonova LA, Agapova OI, Moysenovich MM, Agapov II. The relation of biological properties of the silk fibroin/gelatin scaffolds with the composition and fabrication technology. Modern technologies in medicine. 2023;3(8):6-15. (In Russ.).
  8. Gilbert TW, Gilbert S, Madden M, Reynolds SD, Badylak SF. Morphologic assessment of extracellular matrix scaffolds for patch tracheoplasty in a canine model. Ann Thorac Surg. 2019;86(3):923-925. 
  9. Badylak SF, Freytes DO, Gilbert TW. Extracellular matrix as a biological scaffold material: structure and function. Acta Biomaterialia. 2019; 5:1-13. 
  10. Denisova AV, Safronova EI, Dydykin SS, Kapitonova MYu, Panteleyev AA, Romanova OA, Grigor’yevskiy ED, Kol’chenko SI, Piskunova NN. The experimental model of plastic reconstruction of the defect of the lower respiratory tract with cell engineered constructs. Morphology. 2019;2(155):99. (In Russ.).
  11. Piskunova NN, Kudryavitskiy EE, Grigor’yevskiy ED, Safronova EI, Dydykin SS, Kol’chenko SI, Romanova OA, Panteleyev AA, Vorob’yeva EA. Experimental model for the treatment of upper respiratory tract injuries using tissue-engineered materials. Genes & Cells. 2019;S(14):182-183. (In Russ.).
  12. Patent RF na izobreteniye № 2821401/24.06.2024 Byul. №18. Kudryavtseva TN, Vanina AS, Grekhneva EV, Lipatov VA, Denisov AA, Mishina ES, Sychev AV, Soroka VV, Plotnikov VA, Belous AS. Method of producing porous collagen matrix based on marine collagen using glutaraldehyde. The link is active on 31.03.2025. (In Russ.). \ https://fips.ru/iiss/document.xhtml?faces-redirect=true&id=4848615b68e39a524a8e9e449883508b.
  13. Patent RF №2808686/01.12.2023. Byul. №34. Kudryavtseva TN, Vanina AS, Grekhneva EV, Lipatov VA, Denisov AA, Mishina ES, Sychev AV, Soroka VV, Plotnikov VA, Dzhayavira AChS. Method of porous collagen matrix production. The link is active on 31.03.2025. (In Russ.). https://fips.ru/iiss/document.xhtml?faces-redirect=true&id=af8a07c4e89e5980498d542b8c9348c3.
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.