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Nosulya E.V.

Sverzhevky Research Clinical Institute of Otorhinolaryngology

Borovkova N.V.

Sklifosovsky Research Institute of Emergency Care

Tovmasyan A.S.

Sverzhevsky Research Clinical Institute of Otorhinolaryngology

Ponomarev I.N.

Sklifosovsky Research Institute of Emergency Care

Aleksanyan T.A.

L.I. Sverzhevskiy Research Institute of Clinical Otorhinolaryngology

Polyaeva M.Yu.

Sverzhevsky Scientific Research Clinical Institute of Otorhinolaryngology of the Department of Health of the City of Moscow

Kishinevskiy A.E.

Sverzhevsky Research Clinical Institute of Otorhinolaryngology

Kolbanova I.G.

Sverzhevsky Research Clinical Institute of Otorhinolaryngology

Mosin V.V.

Sverzhevsky Research Clinical Institute of Otorhinolaryngology

Shvedov N.V.

Sverzhevsky Research Clinical Institute of Otorhinolaryngology

Implantation and transplantation materials in plastic closure of nasal septum perforation (literature review)

Authors:

Nosulya E.V., Borovkova N.V., Tovmasyan A.S., Ponomarev I.N., Aleksanyan T.A., Polyaeva M.Yu., Kishinevskiy A.E., Kolbanova I.G., Mosin V.V., Shvedov N.V.

More about the authors

Journal: Russian Bulletin of Otorhinolaryngology. 2025;90(2): 55‑62

DOI: 10.17116/otorino20259002155

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Table of contents

IMPLANTATION AND TRANSPLANTATION MATERIALS IN PLASTIC CLOSURE OF NASAL SEPTUM PERFORATION (LITERATURE REVIEW)
IMPLANTATION AND TRANSPLANTATION MATERIALS IN PLASTIC CLOSURE OF NASAL SEPTUM PERFORATION (LITERATURE REVIEW)

To cite this article:

Nosulya EV, Borovkova NV, Tovmasyan AS, et al. . Implantation and transplantation materials in plastic closure of nasal septum perforation (literature review). Russian Bulletin of Otorhinolaryngology. 2025;90(2):55‑62. (In Russ.)
https://doi.org/10.17116/otorino20259002155

Подписка 2026 Вестник оториноларингологии (Russian Bulletin of Otorhinolaryngology)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The annual increase in the number of operations for the curvature of the nasal septum is accompanied by a proportional increase in the number of complications, for example, the development of nasal septum perforation (NSP). The frequency of NSP detection varies from 0.5% to 8%. In 60% of cases, NSP is defined as iatrogenic and is the result of surgical treatment or injury to the nose. In 12-47% of cases, NSP is idiopathic and develops as a result of chronic subatrophic rhinitis, uncontrolled use of intranasal decongestants and topical glucocorticosteroids, and in rare cases it is a manifestation of systemic diseases. The tactics of surgical treatment of NSP is a highly debatable issue. Historically, the treatment of nasal septum defects has evolved from the lengthening of small “whistling” perforations to the development of autoloscutes of the mucous membrane to perform plastic closure of nasal septum perforation. Studies conducted over the past 20 years have shown that the use of displaced vascularized mucosal flaps is the most effective method of surgical treatment of NSP. The effectiveness of this approach over the past 10 years has ranged from 70% to 90%. However, plastic closure of perforation with mucosal flaps is a very complex and labor-intensive process, it is possible provided the surgeon is highly qualified and has extensive experience, and careful care is provided during a long rehabilitation period. Modern research on the treatment and rehabilitation of patients with NSP is aimed at improving the effectiveness of the surgical stage, simplifying the surgical procedure, and shortening the rehabilitation period through the use of transplant materials and cellular technologies. Based on this, the purpose of our work was to analyze domestic and foreign studies on the use of biotechnological approaches in the closure of nasal septum defects.

Keywords:

rhinosurgery
nasal septum perforation
plastic closure of nasal septum perforation
multipotent stem cells
tissue engineering structures
biotechnology

Authors:

Nosulya E.V.

Sverzhevky Research Clinical Institute of Otorhinolaryngology

Borovkova N.V.

Sklifosovsky Research Institute of Emergency Care

Tovmasyan A.S.

Sverzhevsky Research Clinical Institute of Otorhinolaryngology

Ponomarev I.N.

Sklifosovsky Research Institute of Emergency Care

Aleksanyan T.A.

L.I. Sverzhevskiy Research Institute of Clinical Otorhinolaryngology

Polyaeva M.Yu.

Sverzhevsky Scientific Research Clinical Institute of Otorhinolaryngology of the Department of Health of the City of Moscow

Kishinevskiy A.E.

Sverzhevsky Research Clinical Institute of Otorhinolaryngology

Kolbanova I.G.

Sverzhevsky Research Clinical Institute of Otorhinolaryngology

Mosin V.V.

Sverzhevsky Research Clinical Institute of Otorhinolaryngology

Shvedov N.V.

Sverzhevsky Research Clinical Institute of Otorhinolaryngology

Received:

31.10.2024

Accepted:

06.02.2025

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