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Трансплантология против старения: роль машинной перфузии в заместительной терапии и восстановлении органов

Трансплантология против старения: роль машинной перфузии в заместительной терапии и восстановлении органов

Авторы:
Доброхотов И.В.,
Якушенко Е.В.,
Москалев А.А.

Журнал: Хирургия. Журнал им. Н.И. Пирогова. 2025;(11-2):79-89.

DOI: 10.17116/hirurgia202511279

Прочитано: 1252 раза

Резюме

Увеличение продолжительности жизни без пропорционального увеличения здорового периода жизни является серьезной проблемой современного здравоохранения. Возникает необходимость смещения фокуса медицинских исследований от лечения возраст-связанных заболеваний к устранению основного фактора их развития — старения. На фоне разработки системной антивозрастной терапии рассматриваются органоспецифичные стратегии заместительной терапии. В данном обзоре мы анализируемы современные достижения по использованию машинной перфузия ex situ помимо сохранения органов перед трансплантацией, в качестве платформы для оценки, восстановления и модификации органов. Интеграция машинной перфузии с передовыми биотехнологиями — генной терапией, клеточной терапией мезенхимальными стволовыми клетками, сенотерапией и аптамерными биосенсорами для мониторинга цитокинов в реальном времени — открывает новые возможности для создания органов, устойчивых к старению и ишемически-реперфузионному повреждению. Мы обсуждаем влияние возраста органов на скорость старения организма и оцениваем возможности комбинированных подходов машинной перфузии с молекулярными и клеточными технологиями в качестве платформы для антивозрастной заместительной терапии.

Ключевые слова

  • старение
  • пересадка органов
  • сохранение донорских органов
  • перфузия органов ex vivo
  • регенеративная медицина
  • сенотерапия

Дата поступления: 17.08.2025

Дата принятия в печать: 12.09.2025

Дата публикации: 25.12.2025

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