The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.
Skoropad V.Yu.
A.F. Tsyba Medical Radiological Scientific Center — branch of the National Medical Research Center of Radiology of the Ministry of Health of Russia
Kudryavtsev D.D.
A. Tsyb Medical Radiological Research Centre — Branch of the National Medical Research Radiological Centre
Ivanov S.A.
Tsyb Medical Research Radiology Center;
People’s Friendship University of Russia
Kaprin A.D.
A. Tsyb Medical Radiological Research Centre — Branch of the National Medical Research Radiological Centre;
P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center;
Peoples’ Friendship University of Russia named after Patrice Lumumba
Long-term clinical outcomes of patients with locally advanced gastric adenocarcinoma after two induction cycles of chemotherapy according to the FLOT regimen followed by chemoradiotherapy and radical surgery
Journal: P.A. Herzen Journal of Oncology. 2025;14(2): 5‑12
Views: 351
Downloaded: 17
To cite this article:
Skoropad VYu, Mironova DYu, Kudryavtsev DD, Smolenov EI, Kolobaev IV, Ivanov SA, Kaprin AD. Long-term clinical outcomes of patients with locally advanced gastric adenocarcinoma after two induction cycles of chemotherapy according to the FLOT regimen followed by chemoradiotherapy and radical surgery. P.A. Herzen Journal of Oncology.
2025;14(2):5‑12. (In Russ.)
https://doi.org/10.17116/onkolog2025140215
In recent years, the possibility of neoadjuvant treatment of patients with locally advanced gastric cancer (GC) has been actively studied. One of the proposed directions is the addition of radiation therapy. In order to increase the frequency of the tumor response and radical (R0) resections, to achieve a greater degree of pathological response, reduce the “yp” stage and, finally, to improve long-term results.
Study of treatment results in patients with locally advanced GC through 2 induction cycles of chemotherapy according to FLOT scheme followed by chemoradiotherapy and radical surgery.
A total of 47 patients with locally advanced GC were included. Stage III GC was diagnosed in 27 patients, stage II occurred in 18 patients and stage IV — in 2 patients. High-grade adenocarcinoma was detected in 7 patients, moderate — 13 and low-grade in 23 patients; in 4 cases, signet ring cell adenocarcinoma was occurred. The surgery was attended in 45 patients, in 44 (93.6%) cases was performed radical (R0) surgical treatment.
The three-year overall and recurrence-free survival rate were 74.4±6.5% and 60.1±7.0%, respectively. In comparison with randomized and large retrospective studies by foreign authors, the indicators of treatment completion, the degree of pathological response and long-term results in our study were higher.
Two cycles of FLOT, followed by chemoradiotherapy and radical surgery in patients with locally advanced GC, are associated by a high percentage of treatment completion and cases of radical surgery, pronounced clinical and pathologic response and high rates of three-year overall and disease-free survival.
Keywords:
Authors:
Skoropad V.Yu.
A.F. Tsyba Medical Radiological Scientific Center — branch of the National Medical Research Center of Radiology of the Ministry of Health of Russia
Kudryavtsev D.D.
A. Tsyb Medical Radiological Research Centre — Branch of the National Medical Research Radiological Centre
Ivanov S.A.
Tsyb Medical Research Radiology Center;
People’s Friendship University of Russia
Kaprin A.D.
A. Tsyb Medical Radiological Research Centre — Branch of the National Medical Research Radiological Centre;
P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center;
Peoples’ Friendship University of Russia named after Patrice Lumumba
Received:
01.12.2024
Accepted:
16.12.2024
List of references:
Close metadata
Email Confirmation
An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.
Email Confirmation
Log in to the site using your account in one of the services
We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.