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Aksenov S.A.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center

Khomyakov V.M.

Herzen Moscow Oncology Research Institute — Branch Campus of the National Medical Radiology Research Center

Ryabov A.B.

Hertzen Moscow Cancer Research Center

Kolobaev I.V.

Tsyb Medical Radiology Research Center

Sobolev D.D.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Kuznetsova O.S.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center

Utkina A.B.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Abdulkhakimov N.M.

Hertsen Moscow Oncology Research Institute

Salimzyanov K.I.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Chayka A.V.

Herzen Moscow Oncology Research Institute — Branch Campus of the National Medical Radiology Research Center

Kaprin A.D.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center;
A. Tsyb Medical Radiological Research Center — Branch of the National Medical Radiological Research Center;
Peoples’ Friendship University of Russia named after Patrice Lumumba

Pressurized intraperitoneal aerosol chemotherapy in combination with cytoreductive surgery in patients with gastric cancer and limited peritoneal carcinomatosis

Authors:

Aksenov S.A., Khomyakov V.M., Ryabov A.B., Kolobaev I.V., Sobolev D.D., Kuznetsova O.S., Utkina A.B., Abdulkhakimov N.M., Salimzyanov K.I., Chayka A.V., Kaprin A.D.

More about the authors

Journal: P.A. Herzen Journal of Oncology. 2024;13(5): 18‑24

DOI: 10.17116/onkolog20241305118

Read: 975 times

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Table of contents

PRESSURIZED INTRAPERITONEAL AEROSOL CHEMOTHERAPY IN COMBINATION WITH CYTOREDUCTIVE SURGERY IN PATIENTS WITH GASTRIC CANCER AND LIMITED PERITONEAL CARCINOMATOSIS
PRESSURIZED INTRAPERITONEAL AEROSOL CHEMOTHERAPY IN COMBINATION WITH CYTOREDUCTIVE SURGERY IN PATIENTS WITH GASTRIC CANCER AND LIMITED PERITONEAL CARCINOMATOSIS

To cite this article:

Aksenov SA, Khomyakov VM, Ryabov AB, et al. . Pressurized intraperitoneal aerosol chemotherapy in combination with cytoreductive surgery in patients with gastric cancer and limited peritoneal carcinomatosis. P.A. Herzen Journal of Oncology. 2024;13(5):18‑24. (In Russ.)
https://doi.org/10.17116/onkolog20241305118

Подписка 2026 Онкология. Журнал им. П.А. Герцена (P.A. Herzen Journal of Oncology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Recommended articles:
Intra-abdominal pressurized aero­sol chemotherapy after proximal gastrectomy with double-tract reco­nstruction in a patient with loca­lly adva­nced gastric cancer. P.A. Herzen Journal of Onco­logy. 2025;(3):78-82
Abstract:

Cytoreductive surgery in combination with preoperative chemotherapy (also known as conversion surgery) is a promising treatment option for patients with limited peritoneal carcinomatosis. Local chemotherapy combined with cytoreductive procedures is widely discussed in literature as preventive approach for intraoperative dissemination.

OBJECTIVE

To This study aimed to evaluate the safety and efficacy of Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) in combination with cytoreductive surgery for patients with gastric cancer and limited peritoneal carcinomatosis (PCI < 7).

MATERIAL AND METHODS

Between 2019 and 2023, in total 20 patients with gastric cancer and limited peritoneal carcinomatosis underwent cytoreductive surgeries combined with PIPAC session at the NMIC of Radiology, Ministry of Health, Russian Federation.

RESULTS

Of the 21 patients, 3 (31.1%) had a partial response, in 17 patients primary tumor stabilization was observed after preoperative treatment, in 10 patients (50%), a complete response of peritoneal metastasis was achieved. All patients underwent complete cytoreduction (R0/CC-0). Major pathological response of the primary tumor was achived in 2 (10%) patients — TRG1a per Becker and in 4 (20%) — TRG1b per Becker, TRG2 and TRG3 in 5 (25%) and 9 (45%) patients, respectively. The median overall survival was 27 months and the disease-free survival was 7 months. 1-year and 2-year overall survival rates were 95% and 60%, respectively.

CONCLUSION

Cytoreductive surgery in combination with PIPAC is feasible and safe. The survival rates demonstrate the potential effectiveness of this method. However, in order to make a clear assessment of the efficacy of adjuvant intraperitoneal chemotherapy as an approach for preventing intraoperative dissemination during cytoreductions, further randomized controlled trials is needed.

Keywords:

metastatic gastric cancer
limited peritoneal carcinomatosis
pressurized intraperitoneal aerosol chemotherapy
conversion surgery

Authors:

Aksenov S.A.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center

Khomyakov V.M.

Herzen Moscow Oncology Research Institute — Branch Campus of the National Medical Radiology Research Center

Ryabov A.B.

Hertzen Moscow Cancer Research Center

Kolobaev I.V.

Tsyb Medical Radiology Research Center

Sobolev D.D.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Kuznetsova O.S.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center

Utkina A.B.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Abdulkhakimov N.M.

Hertsen Moscow Oncology Research Institute

Salimzyanov K.I.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Chayka A.V.

Herzen Moscow Oncology Research Institute — Branch Campus of the National Medical Radiology Research Center

Kaprin A.D.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center;
A. Tsyb Medical Radiological Research Center — Branch of the National Medical Radiological Research Center;
Peoples’ Friendship University of Russia named after Patrice Lumumba

Received:

01.05.2024

Accepted:

28.05.2024

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References:

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