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Oleynikova N.A.

Lomonosov Moscow State University

Sycheva I.N.

Lomonosov Moscow State University

Mikhailov I.A.

Lomonosov Moscow State University;
Center of Expertise and Quality Control of Healthcare

Zhestkov I.A.

Lomonosov Moscow State University

Varenzov M.G.

Lomonosov Moscow State University

Malkov P.G.

Lomonosov Moscow State University;
Russian Medical Academy of Continuous Professional Education

Patterns of CAF expression in tumors of the genitourinary system

Authors:

Oleynikova N.A., Sycheva I.N., Mikhailov I.A., Zhestkov I.A., Varenzov M.G., Malkov P.G.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2024;86(6): 28‑35

DOI: 10.17116/patol20248606128

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Table of contents

PATTERNS OF CAF EXPRESSION IN TUMORS OF THE GENITOURINARY SYSTEM
PATTERNS OF CAF EXPRESSION IN TUMORS OF THE GENITOURINARY SYSTEM

To cite this article:

Oleynikova NA, Sycheva IN, Mikhailov IA, Zhestkov IA, Varenzov MG, Malkov PG. Patterns of CAF expression in tumors of the genitourinary system. Russian Journal of Archive of Pathology. 2024;86(6):28‑35. (In Russ.)
https://doi.org/10.17116/patol20248606128

 
Подписка 2025-2 (Russian Journal of Archive of Pathology)
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Cancer-associated fibroblasts (CAF), as the most important component of the tumor microenvironment, have been the subject of targeted study in recent years. There is increasing evidence of CAF heterogeneity and their different roles in tumor progression. However, there is no single marker identifying CAF, and there is also no understanding of the similarity of CAF markers in various tumors of the genitourinary system.

OBJECTIVE

To evaluate the response of CAF markers — FAP and PDGFRα+β in bladder cancer and prostate cancer.

MATERIAL AND METHODS

An immunohistochemical study with antibodies to FAP and PDGFRα+β was conducted on material from 34 patients with prostate cancer and 44 patients with bladder cancer in order to identify statistical relationships with stage, morphological characteristics and survival, as well as to understand the applicability of the same markers for cancer of different localizations.

RESULTS

An increased FAP reaction was shown in prostate cancer with metastases (p=0.0239), a significantly higher number of recurrences in the group with a high PDGFRa+β (3+) reaction (p=0.0018); the presence of FAP reaction only in invasive bladder cancers (p=0.0094) and bladder cancers with high grade dysplasia (p=0.0000234), the absence of a relationship between the level of PDGFRa+β and clinical and morphological characteristics in bladder cancer.

CONCLUSION

Our results confirm the heterogeneity of CAF in both bladder and prostate tumors and indicate that FAP is one of CAF subpopulation marker.

Considering that FAP is expressed in a population of CAFs that lead to resistance to treatment with immune checkpoint inhibitors in melanoma, the FAP marker may also be diagnostically significant for tumors of the genitourinary system, especially given the fact that bladder tumors are treated with the BCG vaccine.

Keywords:

bladder cancer
prostate cancer
cancer-associated fibroblasts
tumor microenvironment
tumor stroma

Authors:

Oleynikova N.A.

Lomonosov Moscow State University

Sycheva I.N.

Lomonosov Moscow State University

Mikhailov I.A.

Lomonosov Moscow State University;
Center of Expertise and Quality Control of Healthcare

Zhestkov I.A.

Lomonosov Moscow State University

Varenzov M.G.

Lomonosov Moscow State University

Malkov P.G.

Lomonosov Moscow State University;
Russian Medical Academy of Continuous Professional Education

Received:

29.05.2024

Accepted:

26.06.2024

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