The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Abdulloeva Sh.Sh.

P.A. Herzen Moscow Oncology Research Institute — Branchof the National Medical Radiology Research Center

Zikiryakhodzhaev A.D.

I.M. Sechenov First Moscow State Medical University (Sechenov University) of the Ministry of Russia;
P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Russia;
Peoples’ Friendship University of Russia

Saribekyan E.K.

P.A. Hertzen Moscow Oncology Research Institute

Vlasova M.Yu.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Russia

Bagdasarova D.V.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Azimova E.K.

P.A. Herzen Moscow Oncology Research Institute — Branchof the National Medical Radiology Research Center

Targeted lymphadenectomy with sentinel lymph node biopsy in patients with breast cancer cT1-3N1M0 after neoadjuvant polychemotherapy

Authors:

Abdulloeva Sh.Sh., Zikiryakhodzhaev A.D., Saribekyan E.K., Vlasova M.Yu., Bagdasarova D.V., Azimova E.K.

More about the authors

Journal: P.A. Herzen Journal of Oncology. 2024;13(3): 73‑78

DOI: 10.17116/onkolog20241303173

Read: 1446 times

Download PDF (RU)
Contact the author
Table of contents

TARGETED LYMPHADENECTOMY WITH SENTINEL LYMPH NODE BIOPSY IN PATIENTS WITH BREAST CANCER CT1-3N1M0 AFTER NEOADJUVANT POLYCHEMOTHERAPY
TARGETED LYMPHADENECTOMY WITH SENTINEL LYMPH NODE BIOPSY IN PATIENTS WITH BREAST CANCER CT1-3N1M0 AFTER NEOADJUVANT POLYCHEMOTHERAPY

To cite this article:

Abdulloeva ShSh, Zikiryakhodzhaev AD, Saribekyan EK, Vlasova MYu, Bagdasarova DV, Azimova EK. Targeted lymphadenectomy with sentinel lymph node biopsy in patients with breast cancer cT1-3N1M0 after neoadjuvant polychemotherapy. P.A. Herzen Journal of Oncology. 2024;13(3):73‑78. (In Russ.)
https://doi.org/10.17116/onkolog20241303173

Подписка 2026 Онкология. Журнал им. П.А. Герцена (P.A. Herzen Journal of Oncology)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Treatment outcomes of stage IIA–IIB breast cancer patients of hormone-positive HER2-negative subtype after neoadjuvant poly­chemotherapy depe­nding on Ki-67 levels. P.A. Herzen Journal of Onco­logy. 2025;(2):13-18
Hema­tological indi­cators of the systemic inflammatory response in the prognosis of lumi­nal HER2-negative breast cancer patients unde­rgoing surgery followed by adju­vant therapy. P.A. Herzen Journal of Onco­logy. 2025;(3):31-38
Hemo­stasis diso­rders during neoadjuvant therapy in patients with breast cancer. P.A. Herzen Journal of Onco­logy. 2025;(3):39-44
Biopsy of the sentinel lymph node and the possibility of performing breast-conserving surgery for the non-inflammatory inva­sive breast cancers with edema. P.A. Herzen Journal of Onco­logy. 2025;(4):96-101
The effect of acetylamide synthetic peptide HLDF-6 on cell differentiation in breast cancer. Russian Journal of Archive of Pathology. 2025;(2):5-10
Repeated breast reco­nstruction after previous complications. Piro­gov Russian Journal of Surgery. 2025;(6):51-57
Guidelines for asse­ssing the quality of mammographic images. Russian Journal of Preventive Medi­cine. 2025;(6):21-32
Inci­dence of regional lymph node meta­stases in patients with early prognostically unfa­vorable mole­cular biological breast cancer. Piro­gov Russian Journal of Surgery. 2025;(7):11-15
Auto­logous fat transplantation into post-lymphadenectomy cavity for prevention of lymphorrhea after total mastectomy. Piro­gov Russian Journal of Surgery. 2025;(7):24-35
Effe­ctiveness of transpupillary thermotherapy in addi­tion to combination chemotherapy for reti­noblastoma. Russian Annals of Ophthalmology. 2025;(3):13-19
Abstract:

Currently, in the treatment of breast cancer, there is a steady trend towards minimizing the aggressiveness of treatment and de-escalating surgical intervention, which pushes clinicians around the world to look for new dicisions. Targeted lymphadenectomy is a method of surgical intervention in areas of regional lymphatic drainage, which includes marking a clinically positive lymph node before neoadjuvant polychemotherapy with various materials (carbon tattoo, radioactive iodine, metal clamps, etc.) followed by its intraoperative removal in combination with sentinel lymph node biopsy. Undoubtedly, targeted lymphadenectomy is an innovative and effective technique designed to be the answer to the question of the optimal volume of lymphadenectomy. This review is devoted to studying the main provisions of new approaches to surgical treatment of regional areas of breast cancer, namely de-escalation of the scope of surgical treatment in areas of regional lymphatic drainage through targeted lymphadenectomy.

Keywords:

breast cancer
sentinel lymph node biopsy
neoadjuvant polychemotherapy
partial and complete response
lymphadenectomy
targeted lymphadenectomy

Authors:

Abdulloeva Sh.Sh.

P.A. Herzen Moscow Oncology Research Institute — Branchof the National Medical Radiology Research Center

Zikiryakhodzhaev A.D.

I.M. Sechenov First Moscow State Medical University (Sechenov University) of the Ministry of Russia;
P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Russia;
Peoples’ Friendship University of Russia

Saribekyan E.K.

P.A. Hertzen Moscow Oncology Research Institute

Vlasova M.Yu.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Russia

Bagdasarova D.V.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Azimova E.K.

P.A. Herzen Moscow Oncology Research Institute — Branchof the National Medical Radiology Research Center

Received:

27.06.2023

Accepted:

25.07.2023

Close metadata

References:

  1. Kaprin AD, Starinskii VV, Shakhzadova AO, eds. Malignant neoplasms in Russia in 2021 (morbidity and mortality). Moscow: MNIOI named after P.A. Herzen — filial FGBU «NMITs Radiology» of the Ministry of Health of Russia; 2022. (In Russ.).
  2. Starkova MV, Grushina TI, Zhavoronkova VV, Orlov II. Quality of life of patients with early breast cancer after surgery with/without axillary lymph node dissection. Modern Issues of Biomedicine. 2022;6(3):298-306.  https://doi.org/10.51871/2588-0500_2022_06_03_34
  3. Tarkowska M, Głowacka-Mrotek I, Nowikiewicz T, Goch A, Zegarski W. Quality of life in women subjected to surgical treatment of breast cancer depending on the procedure performed within the breast and axillary Fossa-A single-center, one year prospective analysis. J Clin Med. 2021;10(7):1339. https://doi.org/10.3390/jcm10071339
  4. Appelgren M, Sackey H, Wengström Y, Johansson K, Ahlgren J, Andersson Y, Bergkvist L, Frisell J, Lundstedt D, Rydén L, et al.; SENOMAC Trialists’ Group. Patient-reported outcomes one year after positive sentinel lymph node biopsy with or without axillary lymph node dissection in the randomized SENOMAC trial. Breast. 2022;63:16-23.  https://doi.org/10.1016/j.breast.2022.02.013
  5. Boileau JF, Poirier B, Basik M, Holloway CM, Gaboury L, Sideris L, Meterissian S, Arnaout A, Brackstone M, McCready DR, et al. Sentinel node biopsy after neoadjuvant chemotherapy in biopsy-proven node-positive breast cancer: the SN FNAC study. J Clin Oncol. 2015;33(3):258-264.  https://doi.org/10.1200/JCO.2014.55.7827
  6. Starkova MV, Zikiryakhodzhaev AD, Grushina TI, Surkova VS, Slavnova EN, Leont’ev AV. Diagnostic value of sentinel lymph node biopsy in patients with early breast cancer. Oncology. Journal named after P.A. Herzen. 2019;8(6):422-427.  https://doi.org/10.17116/onkolog20198061422
  7. Gould EA, Winship T, Philbin PH, Kerr HH. Observations on a “sentinel node” in cancer of the parotid. Cancer. 1960;13:77-78.  https://doi.org/10.1002/1097-0142(196001/02)13:1<77::aid-cncr2820130114>3.0.co;2-d
  8. Cabanas R. An approach for the treatment of penile carcinoma. Cancer. 1977;39(2):456-466.  https://doi.org/10.1002/1097-0142(197702)39:2<456::aid-cncr2820390214>3.0.co;2-i
  9. Morton DL, Wen DR, Wong JH, Economou JS, Cagle LA, Storm FK, Foshag LJ, Cochran AJ. Technical details of intraoperative lymphatic mapping for early stage melanoma. Arch Surg. 1992;127(4):392-399.  https://doi.org/10.1001/archsurg.1992.01420040034005
  10. Giuliano A.E, Jones R.C, Brennan M, Statman R. Sentinel lymphadenectomy in breast cancer. J Clin Oncol. 1997;15(6):2345-2350. https://doi.org/10.1200/JCO.1997.15.6.2345
  11. Natsiopoulos I, Intzes S, Liappis T, Zarampoukas K, Zarampoukas T, Zacharopoulou V, Papazisis K. Axillary lymph node tattooing and targeted axillary dissection in breast cancer patients who presented as cN+ before neoadjuvant chemotherapy and became cN0 after treatment. Clin Breast Cancer. 2019;19(3):208-215.  https://doi.org/10.1016/j.clbc.2019.01.013
  12. Patel R, MacKerricher W, Tsai J, Choy N, Lipson J, Ikeda D, Pal S, De Martini W, Allison KH, Wapnir IL. Pretreatment tattoo marking of suspicious axillary lymph nodes: reliability and correlation with sentinel lymph node. Ann Surg Oncol. 2019;26(8):2452-2458. https://doi.org/10.1245/s10434-019-07419-3
  13. Sun J, Henry DA, Carr MJ, Yazdankhahkenary A, Laronga C, Lee MC, Hoover SJ, Sun W, Czerniecki BJ, Khakpour N, et al. Feasibility of axillary lymph node localization and excision using radar reflector localization. Clin Breast Cancer. 2021;21(3):e189-e193. https://doi.org/10.1016/j.clbc.2020.08.001
  14. Lowes S, Bell A, Milligan R, Amonkar S, Leaver A. Use of Hologic LOCalizer radiofrequency identification (RFID) tags to localise impalpable breast lesions and axillary nodes: experience of the first 150 cases in a UK breast unit. Clin Radiol. 2020;75(12):942-949.  https://doi.org/10.1016/j.crad.2020.08.014
  15. Wang H, Mao X. Evaluation of the efficacy of neoadjuvant chemotherapy for breast cancer. Drug Des Devel Ther. 2020;14:2423-2433. https://doi.org/10.2147/DDDT.S253961
  16. Kahler-Ribeiro-Fontana S, Pagan E, Magnoni F, Vicini E, Morigi C, Corso G, Intra M, Canegallo F, Ratini S, Leonardi MC, et al. Long-term standard sentinel node biopsy after neoadjuvant treatment in breast cancer: a single institution ten-year follow-up. Eur J Surg Oncol. 2021;47(4):804-812.  https://doi.org/10.1016/j.ejso.2020.10.014
  17. Cao S, Liu X, Cui J, Liu X, Zhong J, Yang Z, Sun D, Wei W. Feasibility and reliability of sentinel lymph node biopsy after neoadjuvant chemotherapy in breast cancer patients with positive axillary nodes at initial diagnosis: an up-to-date meta-analysis of 3,578 patients. Breast. 2021;59:256-269.  https://doi.org/10.1016/j.breast.2021.07.015
  18. Simons JM, van Nijnatten TJA, van der Pol CC, Luiten EJT, Koppert LB, Smidt ML. Diagnostic accuracy of different surgical procedures for axillary staging after neoadjuvant systemic therapy in node-positive breast cancer: a systematic review and meta-analysis. Ann Surg. 2019;269(3):432-442.  https://doi.org/10.1097/sla.0000000000003075
  19. Berberoglu K, Erdemir A, Rasa K, Baloglu H, Cakmakci M. Role of gamma probe-assisted intraoperative sentinel lymph node evaluation in predicting axillary breast cancer metastasis after neoadjuvant chemotherapy. Nucl Med Commun. 2020;41(2):120-125.  https://doi.org/10.1097/MNM.0000000000001111
  20. Choi HJ, Kim I, Alsharif E, Park S, Kim JM, Ryu JM, Nam SJ, Kim SW, Yu J, Lee SK, et al. Use of sentinel lymph node biopsy after neoadjuvant chemotherapy in patients with axillary node-positive breast cancer in diagnosis. J Breast Cancer. 2018;21(4):433-441.  https://doi.org/10.4048/jbc.2018.21.e54
  21. Boughey JC, Suman VJ, Mittendorf EA, Ahrendt GM, Wilke LG, Taback B, Leitch AM, Kuerer HM, Bowling M, Flippo-Morton TS, et al.; Alliance for Clinical Trials in Oncology. Sentinel lymph node surgery after neoadjuvant chemotherapy in patients with node-positive breast cancer: the ACOSOG Z1071 (Alliance) clinical trial. JAMA. 2013;310(14):1455-1461. https://doi.org/10.1001/jama.2013.278932
  22. Kuehn T, Bauerfeind I, Fehm T, Fleige B, Hausschild M, Helms G, Lebeau A, Liedtke C, von Minckwitz G, Nekljudova V, et al. Sentinel-lymph-node biopsy in patients with breast cancer before and after neoadjuvant chemotherapy (SENTINA): a prospective, multicentre cohort study. Lancet Oncol. 2013;14(7):609-618.  https://doi.org/10.1016/S1470-2045(13)70166-9
  23. Boileau JF, Poirier B, Basik M, Holloway CM, Gaboury L, Sideris L, Meterissian S, Arnaout A, Brackstone M, McCready DR, et.al. Sentinel node biopsy after neoadjuvant chemotherapy in biopsy-proven node-positive breast cancer: the SN FNAC study. J Clin Oncol. 2015;33(3):258-264.  https://doi.org/10.1200/JCO.2014.55.7827
  24. Hennessy BT, Hortobagyi GN, Rouzier R, Kuerer H, Sneige N, Buzdar AU, Kau SW, Fornage B, Sahin A, Broglio K, et al. Outcome after pathologic complete eradication of cytologically proven breast cancer axillary node metastases following primary chemotherapy. J Clin Oncol. 2005;23(36):9304-9311. https://doi.org/10.1200/JCO.2005.02.5023
  25. Xing Y, Foy M, Cox DD, Kuerer HM, Hunt KK, Cormier JN. Meta-analysis of sentinel lymph node biopsy after preoperative chemotherapy in patients with breast cancer. Br J Surg. 2006;93(5):539-546.  https://doi.org/10.1002/bjs.5209
  26. Burstein HJ, Curigliano G, Thürlimann B, Weber WP, Poortmans P, Regan MM, Senn HJ, Winer EP, Gnant M.; Panelists of the St Gallen Consensus Conference. Customizing local and systemic therapies for women with early breast cancer: the St. Gallen International Consensus Guidelines for treatment of early breast cancer 2021. Ann Oncol. 2021;32(10):1216-1235. https://doi.org/10.1016/j.annonc.2021.06.023
  27. Swarnkar PK, Tayeh S, Michell MJ, Mokbel K. The evolving role of marked lymph node biopsy (MLNB) and targeted axillary dissection (TAD) after neoadjuvant chemotherapy (NACT) for node-positive breast cancer: systematic review and pooled analysis. Cancers (Basel). 2021;13(7):1539. https://doi.org/10.3390/cancers13071539
  28. Emel’yanov AS, Krivorot’ko PV, Zhil’tsova EK, Komyakhov AV, Bus’ko EA, Krzhivitskii PI, Artem’eva AS, Chernaya AV, Novikov SN, Gigolaeva LP, Tabagua TT, Nikolaev KS, Pesotskii RS, Mortada VV, Amirov NS, Channov VS, Ereshhenko SS, Donskikh RV, Zernov KYu, Semiglazov VF. Axillary surgery after neoadjuvant chemotherapy in breast cancer patients downstaging from cN+ to ycN0. Issues of Oncology. 2022;68(3):322-332.  https://doi.org/10.37469/0507-3758-2022-68-3-322-332
  29. Spautz CC, Schunemann Junior E, Budel LR, Cavalcanti TCS, Louveira MH, Junior PG, Nissen LP, Sobreiro BP, Dória MT, Urban CA, et al. Marking axillary nodes with 4% carbon microparticle suspension before neoadjuvant chemotherapy improves sentinel node identification rate and axillary staging. J Surg Oncol. 2020;122(2):164-169.  https://doi.org/10.1002/jso.25928
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.