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Kometova V.V.

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after academician V.I. Kulakov

Mikhaleva L.M.

Avtsyn Research Institute of Human Morphology of Petrovsky National Research Centre of Surgery

Rodionov V.V.

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after academician V.I. Kulakov

Rodionova M.V.

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after academician V.I. Kulakov

NDRG1 protein expression in breast cancer samples, relationship with lymph nodes metastasis

Authors:

Kometova V.V., Mikhaleva L.M., Rodionov V.V., Rodionova M.V.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2024;86(6): 36‑42

DOI: 10.17116/patol20248606136

Read: 1261 times

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Table of contents

NDRG1 PROTEIN EXPRESSION IN BREAST CANCER SAMPLES, RELATIONSHIP WITH LYMPH NODES METASTASIS
NDRG1 PROTEIN EXPRESSION IN BREAST CANCER SAMPLES, RELATIONSHIP WITH LYMPH NODES METASTASIS

To cite this article:

Kometova VV, Mikhaleva LM, Rodionov VV, Rodionova MV. NDRG1 protein expression in breast cancer samples, relationship with lymph nodes metastasis. Russian Journal of Archive of Pathology. 2024;86(6):36‑42. (In Russ.)
https://doi.org/10.17116/patol20248606136

 
Подписка 2026 Архив патологии (Russian Journal of Archive of Pathology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To study the features of protein expression of gene NDRG1 in primary breast cancer (BC) and to identify its relationship with regional metastasis.

MATERIAL AND METHODS

The study included 358 cases of primary BC stages I-III without neoadjuvant chemotherapy with an assessment of a number of clinical, morphological and immunohistochemical parameters of the tumor, including NDRG1 protein expression status and its expression level.

RESULTS

In two study groups with and without metastatic lymph node involvement, a statistically significant relationship was found between NDRG1 expression and histological type of BC, tumor grade, estrogen receptors expression, progesterone receptors expression, HER2 status and index Ki-67 (tumor cell proliferative activity). No statistically significant relationship was found between NDRG1 expression and patient age, tumor node size, and multifocality in two study groups with and without metastatic lymph node involvement.

CONCLUSION

NDRG1 protein expression is statistically significantly associated with regional metastasis of breast cancer (p=0.015). The differences were due to a higher frequency of cases with NDRG1 positive versus negative status in the group of breast cancer with lymph node metastases.

Keywords:

breast cancer
NDRG1
regional metastasis
lymph nodes

Authors:

Kometova V.V.

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after academician V.I. Kulakov

Mikhaleva L.M.

Avtsyn Research Institute of Human Morphology of Petrovsky National Research Centre of Surgery

Rodionov V.V.

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after academician V.I. Kulakov

Rodionova M.V.

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after academician V.I. Kulakov

Received:

06.09.2024

Accepted:

16.09.2024

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References:

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