OBJECTIVE

To assess the quality of life in patients with newly diagnosed ovarian cancer accompanied by peritoneal carcinomatosis after standard combined treatment and pressurized intraperitoneal aerosol chemotherapy (PIPAC).

MATERIAL AND METHODS

The study included 164 women with newly diagnosed ovarian cancer who underwent hysterectomy with adnexectomy and omentectomy. After intraoperative randomization, 79 patients were included in the study group (1st group) who received three PIPAC sessions in addition to standard combined treatment. Women in the 2nd group (n=85) received standard combined treatment. The total follow-up period for patients was 90 days. The general condition and quality of life were assessed on days 14, 50, and 90 using the ECOG scale and the EORTC QLQ-C30 questionnaire (version 3), respectively.

RESULTS

The results showed that the general condition and quality of life after primary surgical treatment did not differ significantly. At 3 months of follow-up, the scores characterizing the general condition of women on the ECOG scale in the PIPAC group were 1.75 times higher compared to the 2nd group (p=0.017). Similarly, in this group, the scores characterizing the quality of life on the EORTC-QLQ-C30 questionnaire (version 3) were 3.5 points higher compared to the control group (p=0.025). In the control group, there were 72 cases of recurrence and 11 deaths, while in the study group, there were 41 cases of recurrence and 4 deaths. Mathematical analysis of the data revealed that the median recurrence-free survival in the study group was 8 months longer than in the control group.

CONCLUSION

The quality of life and general condition of patients in the PIPAC group were better than those in the control group. This phenomenon remained stable throughout the study.