Characteristics of the phagocytic component of the immune system in early-stage gastric cancer

Smirnova O.V.

Research Institute for the Medical Problems of the North — Krasnoyarsk Research Center of the Russian Academy of Sciences

ORCID: 0000-0003-3992-9207

Ovcharenko E.S.

Research Institute for the Medical Problems of the North — Krasnoyarsk Research Center of the Russian Academy of Sciences

ORCID: 0000-0001-6884-7871

Kasparov E.V.

Research Institute for the Medical Problems of the North — Krasnoyarsk Research Center of the Russian Academy of Sciences

ORCID: 0000-0002-5988-1688

Sinyakov A.A.

Research Institute for the Medical Problems of the North — Krasnoyarsk Research Center of the Russian Academy of Sciences

ORCID: 0000-0002-4474-1893

Characteristics of the phagocytic component of the immune system in early-stage gastric cancer

Authors:

Smirnova O.V., Ovcharenko E.S., Kasparov E.V., Sinyakov A.A.

More about the authors

Journal: P.A. Herzen Journal of Oncology. 2023;12(4): 30‑34

DOI: 10.17116/onkolog20231204130

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To cite this article:

Smirnova OV, Ovcharenko ES, Kasparov EV, Sinyakov AA. Characteristics of the phagocytic component of the immune system in early-stage gastric cancer. P.A. Herzen Journal of Oncology. 2023;12(4):30‑34. (In Russ.)
https://doi.org/10.17116/onkolog20231204130

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OBJECTIVE

To estimate the informative value of the phagocytic component of the immune system in the screening of early GC.

SUBJECTS AND METHODS

A total of 132 people, including 45 patients with GC at its early stage I—II GC, were examined. A control group consisted of 87 apparently healthy donors. Chemiluminescence analysis of spontaneous and induced production of active oxygen species was used as a method to examine the antitumor activity of neutrophilic granulocytes and monocytes.

RESULTS AND DISCUSSION

In GC group, the intensity of spontaneous and induced chemilumnescence of neutrophils is considerably lower than that in the control group (p<0.05), whereas the area under the curve of spontaneous and induced chemilumnescence in patients with GC was 6.5 and 6.8 times, respectively, as large as that of the control values. Analysis of the chemiluminescence activity of monocytes in patients with GC revealed a decrease in the values of spontaneous and induced chemiluninence (p<0.05) as compared to the control group. The patients with GC were also seen to have a lower level of granulocytic and monocytic phagocytosis than those in the control group (p<0.05).

CONCLUSION

The found features of the phagocytic component of the immune system may be used in the screening of apparently healthy individuals in order to identify the early signs of immune disorders that absolutely require further clarifications. The immune deficiency syndrome in tumor diseases is a nonspecific and universal component of the pathological process, which is once again confirmed by the findings. Therefore, the signs of immune deficiency in the presence of symptoms of gastric disease increase the probability of detecting GC at its early stages.

Keywords:

gastric cancer

neutrophils

monocytes

phagocytic component

screening

chemiluminescence

Authors:

Smirnova O.V.

Research Institute for the Medical Problems of the North — Krasnoyarsk Research Center of the Russian Academy of Sciences

ORCID: 0000-0003-3992-9207

Ovcharenko E.S.

Research Institute for the Medical Problems of the North — Krasnoyarsk Research Center of the Russian Academy of Sciences

ORCID: 0000-0001-6884-7871

Kasparov E.V.

Research Institute for the Medical Problems of the North — Krasnoyarsk Research Center of the Russian Academy of Sciences

ORCID: 0000-0002-5988-1688

Sinyakov A.A.

Research Institute for the Medical Problems of the North — Krasnoyarsk Research Center of the Russian Academy of Sciences

ORCID: 0000-0002-4474-1893

Received:

23.09.2022

Accepted:

14.12.2022

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