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Zikiryakhodzhaev A.D.

I.M. Sechenov First Moscow State Medical University (Sechenov University) of the Ministry of Russia;
P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Russia;
Peoples’ Friendship University of Russia

Volchenko N.N.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Rozhkova N.N.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Fedenko A.A.

Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center

Kolomeitseva A.A.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Maksimov K.V.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Bagdasarova D.V.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Mazo M.L.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center

Surkova V.S.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Usov F.N.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Starkova M.V.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Kupriyanov P.I.

I.M. Sechenov First Moscow State Medical University (Sechenov University) of the Ministry of Health of Russia

Study of the efficacy of multifocal breast biopsy in patients with a complete clinical response after neoadjuvant polychemotherapy in the combination treatment of breast cancer

Authors:

Zikiryakhodzhaev A.D., Volchenko N.N., Rozhkova N.N., Fedenko A.A., Kolomeitseva A.A., Maksimov K.V., Bagdasarova D.V., Mazo M.L., Surkova V.S., Usov F.N., Starkova M.V., Kupriyanov P.I.

More about the authors

Journal: P.A. Herzen Journal of Oncology. 2022;11(6): 5‑11

DOI: 10.17116/onkolog2022110615

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Table of contents

STUDY OF THE EFFICACY OF MULTIFOCAL BREAST BIOPSY IN PATIENTS WITH A COMPLETE CLINICAL RESPONSE AFTER NEOADJUVANT POLYCHEMOTHERAPY IN THE COMBINATION TREATMENT OF BREAST CANCER
STUDY OF THE EFFICACY OF MULTIFOCAL BREAST BIOPSY IN PATIENTS WITH A COMPLETE CLINICAL RESPONSE AFTER NEOADJUVANT POLYCHEMOTHERAPY IN THE COMBINATION TREATMENT OF BREAST CANCER

To cite this article:

Zikiryakhodzhaev AD, Volchenko NN, Rozhkova NN, et al. . Study of the efficacy of multifocal breast biopsy in patients with a complete clinical response after neoadjuvant polychemotherapy in the combination treatment of breast cancer. P.A. Herzen Journal of Oncology. 2022;11(6):5‑11. (In Russ.)
https://doi.org/10.17116/onkolog2022110615

Подписка 2026 Онкология. Журнал им. П.А. Герцена (P.A. Herzen Journal of Oncology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To evaluate the reliability of histological multifocal biopsy results in patients with breast cancer (BC) after neoadjuvant polychemotherapy (NAPCT) with a complete clinical response (CCR).

SUBJECTS AND METHODS

The study analyzed 35 patients with cT1—3N0—3M0 BC of different molecular biological types, who were diagnosed with CCR after NAPCT. All the patients underwent 12—14-gauge needle multifocal biopsy of the breast, followed by morphological study, thereafter surgical treatment was performed. Furthermore, the morphological findings of the multifocal biopsy and surgical material were compared.

RESULTS

Due to the fact that in 13 out of the 35 multifocal biopsy cases, insufficient material was obtained for morphological evidence for therapeutic pathomorphism, the overall sensitivity and specificity of the technique were 16.7% (CI: 4.3—45.9%) and 100% (CI: 0.2—20.6%), respectively; the false negative result was 23.8% (n=5) (CI: 11.3—41.9%), the false positive one was 0%. The overall diagnostic accuracy of the method was 77.2% (CI: 59.7—89.3%).

CONCLUSION

To increase the percentage of reliable results for the degree of therapeutic pathomorphism in the morphological evidence provided by 12—14-gauge needle multifocal biopsy, it is necessary to take larger amounts of material.

Keywords:

breast cancer
complete clinical response
complete morphopathological response
multifocal biopsy
neoadjuvant polychemotherapy

Authors:

Zikiryakhodzhaev A.D.

I.M. Sechenov First Moscow State Medical University (Sechenov University) of the Ministry of Russia;
P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Russia;
Peoples’ Friendship University of Russia

Volchenko N.N.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Rozhkova N.N.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Fedenko A.A.

Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center

Kolomeitseva A.A.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Maksimov K.V.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Bagdasarova D.V.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Mazo M.L.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center

Surkova V.S.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Usov F.N.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Starkova M.V.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Kupriyanov P.I.

I.M. Sechenov First Moscow State Medical University (Sechenov University) of the Ministry of Health of Russia

Received:

27.07.2022

Accepted:

06.09.2022

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References:

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