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Sergeeva N.S.
Russian University of Peoples' Friendship
Marshutina N.V.
FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdravsotsrazvitiia Rossii
Solokhina M.P.
FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdravsotsrazvitiia Rossii
Alentov I.I.
FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava Rossii
Kaprin A.D.
FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava Rossii
Clinical significance of CA 72-4 as a serological tumor-associated marker
Journal: P.A. Herzen Journal of Oncology. 2019;8(2): 120‑125
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To cite this article:
Sergeeva NS, Marshutina NV, Solokhina MP, Alentov II, Kaprin AD. Clinical significance of CA 72-4 as a serological tumor-associated marker. P.A. Herzen Journal of Oncology.
2019;8(2):120‑125. (In Russ.)
https://doi.org/10.17116/onkolog20198021120
The serological tumor-associated marker CA 72-4 is traditionally positioned as a marker for mucinous ovarian cancer and gastric cancer, being considered relatively highly tumor-specific. However, in clinical practice, some of the examinees without cancer processes were found to have an increase in the serum levels of the marker (by 2.0—2.5 times higher than the upper limit of the normal range). This served as a basis for revising the data available in the literature regarding this marker. The review presents the history of discovery of CA 72-4, its structure, cellular functions, and tissue and serum expression in different physiological states, in non-tumor pathological processes, and in benign and malignant tumors.
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Authors:
Sergeeva N.S.
Russian University of Peoples' Friendship
Marshutina N.V.
FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdravsotsrazvitiia Rossii
Solokhina M.P.
FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdravsotsrazvitiia Rossii
Alentov I.I.
FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava Rossii
Kaprin A.D.
FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava Rossii
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