Objective — to estimate the significance of risk factors from overall survival rates on the basis of a 20-year retrospective study. Subjects and methods. In 1980—2000, one hundred and three of the 339 patients with Stages I—IV Hodgkin’s lymphoma (HL) received preventive radiation to the entire volume of lung tissue (1—16 Gy) and/or liver (2—20 Gy) and 204 patients had a standard radiotherapy program. Pure radiotherapy was used in 22.1%, combined treatment involving a COPP (MOPP) regimen was employed in 77.9% of the patients. Results. During first-line chemotherapy, 33 (9.7%) patients were recorded to have drug-resistant HL and excluded from the study. The median follow-up of the treated patients was 7.9 (0.51—30.93) years: 11 and 6.9 years in the organ radiation and standard program groups, respectively. Ten-year relapse-free survival rates were 74.9 and 53.3% and twenty-year ones were 7.9 and 48.2%; 10-year overall survival rates were 77.7 and 68.8% and 20-year ones were 56.2 and 55.6%. In the examined groups, 20-year overall tumor-specific survival rates were 79.2 and 63.6%, respectively. Logistic regression analysis showed that the probability that a patient would be dead was 2.2 times higher in the standard radiotherapy group (p=0.027) and 1.9 times lower in the COPP group (p=0.038). According to fatal complications, 20-year overall survival rates were 70.9 and 80.1%, respectively. Logistic regression analysis revealed that the significant risk factors were pneumonitis (p=0.011) and preventive radiation of the entire volume of the liver (p=0.011); the risk of death after its radiation was 3.3 times higher. If Radiation Therapy Oncology Group (RTOG) Grade 3—4 pneumonitis was present, the risk of death 20—25 years after the performed treatment was close to 100%. Conclusion. During the first 20 years of a follow-up, the survival rate was higher in the organ radiation treatment group; then the curve crossed and, due to mortality from treatment-related complications, long-term survival rates levelled off.