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Lemaeva A.A.

A. Tsyb Medical Radiological Research Centre — Branch of the National Medical Research Radiological Centre

Gulidov I.A.

A. Tsyb Medical Radiological Research Centre — Branch of the National Medical Research Radiological Centre

Gordon K.B.

A. Tsyb Medical Radiological Research Centre — Branch of the National Medical Research Radiological Centre;
Peoples’ Friendship University of Russia named after Patrice Lumumba

Gogolin D.V.

Beloostrov High-Tech Clinic

Mardynsky Yu.S.

A. Tsyb Medical Radiological Research Centre — Branch of the National Medical Research Radiological Centre

Ivanov S.A.

A. Tsyb Medical Radiological Research Centre — Branch of the National Medical Research Radiological Centre;
Peoples’ Friendship University of Russia named after Patrice Lumumba

Kaprin A.D.

Peoples’ Friendship University of Russia named after Patrice Lumumba;
National Medical Research Radiological Centre;
P. Hertsen Moscow Oncology Research Institute — Branch of the National Medical Research Radiological Centre

Proton therapy of skull base chordoma

Authors:

Lemaeva A.A., Gulidov I.A., Gordon K.B., Gogolin D.V., Mardynsky Yu.S., Ivanov S.A., Kaprin A.D.

More about the authors

Journal: P.A. Herzen Journal of Oncology. 2025;14(5): 64‑67

DOI: 10.17116/onkolog20251405164

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Table of contents

PROTON THERAPY OF SKULL BASE CHORDOMA
PROTON THERAPY OF SKULL BASE CHORDOMA

To cite this article:

Lemaeva AA, Gulidov IA, Gordon KB, Gogolin DV, Mardynsky YuS, Ivanov SA, Kaprin AD. Proton therapy of skull base chordoma. P.A. Herzen Journal of Oncology. 2025;14(5):64‑67. (In Russ.)
https://doi.org/10.17116/onkolog20251405164

Подписка 2026 Онкология. Журнал им. П.А. Герцена (P.A. Herzen Journal of Oncology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Skull base chordomas are rare tumors. They are located nearby to the brain’s most critical structures. This represents a major challenge in the treatment of these tumors. Despite advances in surgery, radical resection is often not possible, thus necessitating the use of radiation therapy. Proton therapy is the most effective and precise method of radiation therapy for this localization of chordomas. This article presents our own experience with intensity modulated proton therapy (IMPT) of a fixed pencil beamline in the treatment of a patient with a skull base chordoma.

Keywords:

chordoma
skull base
radiation therapy
proton therapy

Authors:

Lemaeva A.A.

A. Tsyb Medical Radiological Research Centre — Branch of the National Medical Research Radiological Centre

Gulidov I.A.

A. Tsyb Medical Radiological Research Centre — Branch of the National Medical Research Radiological Centre

Gordon K.B.

A. Tsyb Medical Radiological Research Centre — Branch of the National Medical Research Radiological Centre;
Peoples’ Friendship University of Russia named after Patrice Lumumba

Gogolin D.V.

Beloostrov High-Tech Clinic

Mardynsky Yu.S.

A. Tsyb Medical Radiological Research Centre — Branch of the National Medical Research Radiological Centre

Ivanov S.A.

A. Tsyb Medical Radiological Research Centre — Branch of the National Medical Research Radiological Centre;
Peoples’ Friendship University of Russia named after Patrice Lumumba

Kaprin A.D.

Peoples’ Friendship University of Russia named after Patrice Lumumba;
National Medical Research Radiological Centre;
P. Hertsen Moscow Oncology Research Institute — Branch of the National Medical Research Radiological Centre

Received:

17.01.2025

Accepted:

04.02.2025

Close metadata

References:

  1. Mizerny B, Kost K. Chordoma of the cranial base: the McGill experience. J Otolaryngol.1995; 24(1): 14-9. 
  2. Lee S, Lim Y, Song M, Seok J, Lee W, Choi E. Chondrosarcoma of the head and neck. Yonsei Med J. 2005; 46(2): 228-32.  https://doi.org/10.3349/ymj.2005.46.2.228
  3. Tenny S, Varacallo M. Chordoma. Treasure Island (FL): StatPearls Publishing; 2022.
  4. Kremenevski N, Schlafer S-M, Coras T, Kinfe T.M, Graillon T, Buchfelder M. Skull base chordomas and chondrosarcomas. Neuroendocrinology 2020; 110: 836-47.  https://doi.org/10.1159/000509386
  5. Roberti F, Sekhar L, Jones R, Wright D. Intradural cranial chordoma: a rare presentation of an uncommon tumor. Surgical experience and review of the literature. J Neurosurg. 2007; 106(2): 270-4.  https://doi.org/10.3171/jns.2007.106.2.270
  6. Lustig L, Sciubba J, Holliday M. Chondrosarcomas of the skull base and temporal bone. J Laryngol Otol 2007; 121(8): 725-35.  https://doi.org/10.1017/s0022215107006081
  7. Fossati P, Vavassori A, Deantonio L, Ferrara E, Krengli M, Orecchia R. Review of photon and proton radiotherapy for skull base tumours. Rep Pract Oncol Radiother 2016; 21(4): 336-355.  https://doi.org/10.1016/j.rpor.2016.03.007
  8. Palavani L, Borges P, Andreo F, Borges J, Batista S, Oliveira L, Ferreira M, Abraho Reis P, Pontes J, Negri H, Beer-Furlan A, Krishna Ch, Bertani R, Rassi M. Optimizing radiotherapy strategies for skull base chordoma: a comprehensive meta-analysis and systematic review of treatment modalities and outcomes. Neurosurg Focus. 2024;56(5):E11.  https://doi.org/10.3171/2024.2.FOCUS2413
  9. Munzenrider J, Liebsch N. Proton therapy for tumors of the skull base. Strahlether Onkol. 1999; 175(S2), 57-63.  https://doi.org/10.1007/bf03038890
  10. Hug E, Loredo L, Slater J. Proton radiation therapy for chordomas and chondrosarcomas of the skull base. J Neurosurg. 1999; 91(3): 432-439.  https://doi.org/10.1016/b978-0-12-804257-1.00032-3
  11. Ares C, Hug E, Lomax A, Bolsi A, Timmermann B, Rutz H, Schuller J, Pedroni E, Goitein G. Effectiveness and safety of spot scanning proton radiation therapy for chordomas and chondrosarcomas of the skull base: first long-term report. Int J Radiat Oncol Biol Phys. 2009;75(4):1111-8.  https://doi.org/10.1016/j.ijrobp.2008.12.055
  12. Weber D, Malyapa R, Albertini F, Bolsi A, Kliebsch U, Walser M, Pica A, Combescure Ch, Lomax A, Schneider R. Long term outcomes of patients with skull-base low-grade chondrosarcoma and chordoma patients treated with pencil beam scanning proton therapy. Radiother Oncol. 2016;120(1):169-74.  https://doi.org/10.1016/j.radonc.2016.05.011
  13. Terahara A, Niemierko A, Goitein M, Finkelstein D, Hug E, Liebsch N, O’Farrell D, Lyons S, Munzenrider J. Analysis of the relationship between tumor dose inhomogeneity and local control in patients with skull base chordoma. International Journal of Radiation Oncology Biology Physics. 1999;45:351-8.  https://doi.org/10.1016/S0360-3016(99)00146-7
  14. Noël G, Feuvret L, Ferrand R, Boisserie G, Mazeron J-J, Habrand J-L. Radiotherapeutic factors in the management of cervical-basal chordomas and chondrosarcomas. Neurosurgery. 2004;55:1252-60; discussion 1260-2.  https://doi.org/10.1227/01.neu.0000143330.30405.aa
  15. Basler L, Poel R, Schröder C, Bolsi A, Lomax A, Tanadini-Lang S, Guckenberger M, Weber D. Dosimetric analysis of local failures in skull-base chordoma and chondrosarcoma following pencil beam scanning proton therapy. Radiation Oncology. 2020;15:266.  https://doi.org/10.1186/s13014-020-01711-3
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