Use of glutoxim in gastric cancer patients receiving platinum-containing chemotherapy

Manikhas G.M.; Zhukova N.V.

doi:https://doi.org/

Manikhas G.M.

SPB GUZ "Gorodskoĭ klinicheskiĭ onkologicheskiĭ dispanser", kafedra onkologii FPO Sankt-Peterburgskogo gosudarstvennogo meditsinskogo universiteta im. I.P. Pavlova

Zhukova N.V.

SPB GUZ "Gorodskoĭ klinicheskiĭ onkologicheskiĭ dispanser", kafedra onkologii FPO Sankt-Peterburgskogo gosudarstvennogo meditsinskogo universiteta im. I.P. Pavlova

Use of glutoxim in gastric cancer patients receiving platinum-containing chemotherapy

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Manikhas G.M., Zhukova N.V.

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Journal: P.A. Herzen Journal of Oncology. 2012;1(1): 44‑46

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Manikhas GM, Zhukova NV. Use of glutoxim in gastric cancer patients receiving platinum-containing chemotherapy. P.A. Herzen Journal of Oncology. 2012;1(1):44‑46. (In Russ.)

Подписка 2026 Онкология. Журнал им. П.А. Герцена (P.A. Herzen Journal of Oncology)

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Abstract:

The effectiveness of prevention of complications due to chemotherapy (cisplatin + 5-fluorouracil) was analyzed in patients operated on for gastric cancer. All the patients (n=51) were divided into 2 groups depending on the use of hemoimmunostimulation therapy (Glutoxim). Hematological complications were evaluated. It was revealed that use of Glutoxim reduces frequency of severe neutropenia by 1.8 times and frequency of thrombocytopenia by 1.6 times in comparison with the control group.

Keywords:

gastric cancer

chemotherapy complications

Glutoxim

Authors:

Manikhas G.M.

SPB GUZ "Gorodskoĭ klinicheskiĭ onkologicheskiĭ dispanser", kafedra onkologii FPO Sankt-Peterburgskogo gosudarstvennogo meditsinskogo universiteta im. I.P. Pavlova

Zhukova N.V.

SPB GUZ "Gorodskoĭ klinicheskiĭ onkologicheskiĭ dispanser", kafedra onkologii FPO Sankt-Peterburgskogo gosudarstvennogo meditsinskogo universiteta im. I.P. Pavlova

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References:

Gorbunova V.A., Marenich A.F., Mindra N.V., Zubrikhina G.N. Izuchenie gemostimuliruyushchikh svoistv preparata glutoksim u bol'nykh NMRL, poluchayushchikh tsitostaticheskuyu khimioterapiyu. V kn.: Tezisy dokladov X natsional'nogo kongressa "Chelovek i lekarstvo". M 2003; 489.
Gorbunova V.A., red. Lekarstvennoe lechenie raka zheludka i kolorektal'nogo raka. Gorbunova V.A., Besova N.S., Breder V.V. i dr.; 2-e izd. M: Litera, 2011; 98-145.
Davydov M.I., Aksel' E.M. Statistika zlokachestvennykh novoobrazovanii v Rossii i stranakh SNG v 2007 g. Vestn RONTs im. N.N. Blokhina RAMN 2009; 20: 3, pril. 1: 8-17; 91-100.
Manikhas G.M., Filatova E.I., Bylinskaya E.N. i dr. Primenenie preparata glutoksima pri sochetannoi luchevoi terapii mestno-rasprostranennogo raka sheiki matki. Ros onkol zhurn 2008; 1: 23-28.
Merabishvili V.M., Shcherbuk Yu.A. Onkologicheskaya sluzhba v Sankt-Peterburge i raionakh goroda v 2009 godu. Ezhegodnik populyatsionnogo rakovogo registra. SPb 2010; 16: 31-35.
Smirnov A.I., Kozhemyakin L.A., Levashev Yu.N., Orlov S.V. Serosoderzhashchie oligopeptidy v lechenii bol'nykh nemelkokletochnym rakom legkikh. V kn.: Tret'ya ezhegodnaya rossiiskaya onkologicheskaya konferentsiya. SPb 1999; 140-141.
Chissov V.I., Starinskii V.V., Petrova G.V., red. Zlokachestvennye novoobrazovaniya v Rossii v 2009 godu (zabolevaemost' i smertnost'). M: FGU "MNIOI im. P.A. Gertsena" Minzdravsotsrazvitiya Rossii 2011; 4-5, 13-15, 130-137.
Bittoni A., Maccaroni E., Scartozzi M. et al. Chemotherapy for locally advanced and metastatic gastric cancer: state of the art and future perspectives. Eur Rev Med Pharmacol Sci 2010; 14: 4: 309-314.
Cunningham D., Allum W.H., Stenning S.H. et al. Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. N Engl J Med 2006; 355: 1: 11-20.
Fujisaki S., Takashina M., Tomita R. et al. Improvements in quality of life and survival of patients with T4 gastric cancer which invaded organs after multivisceral resections through the extension of palliative gastrectomy and post-operative chemotherapy. Gan To Kagaku Ryoho 2006; 33: 12: 1881-1884.
Jain V.K., Cunningham D., Chau I. Preoperative and postoperative chemotherapy for gastric cancer. Surg Oncol Clin N Am 2012; 21: 1: 99-112.
MacDonald J.S., Smalley S.R., Benedetti J. et al. Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastrooesophageal junction. N Eng J Med 2001; 345: 10: 725-730.
Sakuramoto S., Sasako M., Yamaguchi T. et al., ACTS-GC Group. Adjuvant chemotherapy for gastric cancer with S-1, an oral fluoropyrimidine. N Engl J Med. 2007; 357: 18: 1810-1820.
Zhang X.F., Huang C.M., Lu H.S. et al. Surgical treatment and prognosis of gastric cancer in 2613 patients. World J Gastroenterol 2004; 10: 23: 3405-3408.