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Kosenko I.A.

Respublikanskiĭ nauchno-prakticheskiĭ tsentr onkologii i meditsinskoĭ radiologii im. N.N. Aleksandrova, Minsk, Respublika Belarus'

Matylevich O.P.

Respublikanskiĭ nauchno-prakticheskiĭ tsentr onkologii i meditsinskoĭ radiologii im. N.N. Aleksandrova, Minsk, Respublika Belarus'

Dudarev V.S.

Respublikanskiĭ nauchno-prakticheskiĭ tsentr onkologii i meditsinskoĭ radiologii im. N.N. Aleksandrova, Minsk, Respublika Belarus'

Litvinova T.M.

Respublikanskiĭ nauchno-prakticheskiĭ tsentr onkologii i meditsinskoĭ radiologii im. N.N. Aleksandrova, Minsk, Respublika Belarus'

Orekhov V.F.

Respublikanskiĭ nauchno-prakticheskiĭ tsentr onkologii i meditsinskoĭ radiologii im. N.N. Aleksandrova, Minsk, Respublika Belarus'

Fomina I.N.

Respublikanskiĭ nauchno-prakticheskiĭ tsentr onkologii i meditsinskoĭ radiologii im. N.N. Aleksandrova, Minsk, Respublika Belarus'

Kurchina T.M.

Respublikanskiĭ nauchno-prakticheskiĭ tsentr onkologii i meditsinskoĭ radiologii im. N.N. Aleksandrova, Minsk, Respublika Belarus'

Osipova T.V.

Respublikanskiĭ nauchno-prakticheskiĭ tsentr onkologii i meditsinskoĭ radiologii im. N.N. Aleksandrova, Minsk, Respublika Belarus'

Efficiency of combination treatment for locally advanced cancer of the cervix uteri by uterine artery chemoembolization

Authors:

Kosenko I.A., Matylevich O.P., Dudarev V.S., Litvinova T.M., Orekhov V.F., Fomina I.N., Kurchina T.M., Osipova T.V.

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Journal: P.A. Herzen Journal of Oncology. 2012;1(1): 15‑19

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To cite this article:

Kosenko IA, Matylevich OP, Dudarev VS, et al. . Efficiency of combination treatment for locally advanced cancer of the cervix uteri by uterine artery chemoembolization. P.A. Herzen Journal of Oncology. 2012;1(1):15‑19. (In Russ.)

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A comprehensive method comprising neoadjuvant chemotherapy (NACT) with gemcitabine and cisplatin and chemoembolization of one or two uterine arteries (CEUA) with gemcitabine, a brachytherapy session in a dose of 10 Gy, type III hysterectomy with appendages, and bilateral lymphadenectomy was developed and used in 42 of 55 patients with locally advanced cancer of the cervix uteri. Radiotherapy was continued in 13 women with an unresectable tumor. After CEUA, 65.4 and 21.4% of the women developed post-embolization syndrome and toxic complications, respectively. The radicality of the surgery after NACT with CEUA was 92.9%; the frequency of postoperative complications was 11.9%. Overall 3-year survival rates were 82.3%; relapse-free survival, 84.6%; metastasis-free survival, 88.4%.

Keywords:

neoadjuvant chemotherapy
uterine artery chemoembolization
locally advanced cancer of the cervix uteri
complications
survival

Authors:

Kosenko I.A.

Respublikanskiĭ nauchno-prakticheskiĭ tsentr onkologii i meditsinskoĭ radiologii im. N.N. Aleksandrova, Minsk, Respublika Belarus'

Matylevich O.P.

Respublikanskiĭ nauchno-prakticheskiĭ tsentr onkologii i meditsinskoĭ radiologii im. N.N. Aleksandrova, Minsk, Respublika Belarus'

Dudarev V.S.

Respublikanskiĭ nauchno-prakticheskiĭ tsentr onkologii i meditsinskoĭ radiologii im. N.N. Aleksandrova, Minsk, Respublika Belarus'

Litvinova T.M.

Respublikanskiĭ nauchno-prakticheskiĭ tsentr onkologii i meditsinskoĭ radiologii im. N.N. Aleksandrova, Minsk, Respublika Belarus'

Orekhov V.F.

Respublikanskiĭ nauchno-prakticheskiĭ tsentr onkologii i meditsinskoĭ radiologii im. N.N. Aleksandrova, Minsk, Respublika Belarus'

Fomina I.N.

Respublikanskiĭ nauchno-prakticheskiĭ tsentr onkologii i meditsinskoĭ radiologii im. N.N. Aleksandrova, Minsk, Respublika Belarus'

Kurchina T.M.

Respublikanskiĭ nauchno-prakticheskiĭ tsentr onkologii i meditsinskoĭ radiologii im. N.N. Aleksandrova, Minsk, Respublika Belarus'

Osipova T.V.

Respublikanskiĭ nauchno-prakticheskiĭ tsentr onkologii i meditsinskoĭ radiologii im. N.N. Aleksandrova, Minsk, Respublika Belarus'

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