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Shilin S.S.

Peoples’ Friendship University of Russia (RUDN University)

Emets Y.I.

Peoples’ Friendship University of Russia (RUDN University)

Spirin E.A.

Peoples’ Friendship University of Russia (RUDN University)

Gusev K.S.

Peoples’ Friendship University of Russia (RUDN University)

Antonyan A.A.

Peoples’ Friendship University of Russia (RUDN University)

Dolgonovskaya A.S.

Peoples’ Friendship University of Russia (RUDN University)

Piskarev D.V.

Peoples’ Friendship University of Russia (RUDN University)

Popadyuk V.I.

Peoples’ Friendship University of Russian

Kastyro I.V.

People’s Friendship University of Russia

Ganshin I.B.

Peoples’ Friendship University of Russia

Vasyakova S.M.

Peoples’ Friendship University of Russia (RUDN University)

The role of G1082A IL-10 polymorphism in pharyngeal tonsil hypertrophy

Authors:

Shilin S.S., Emets Y.I., Spirin E.A., Gusev K.S., Antonyan A.A., Dolgonovskaya A.S., Piskarev D.V., Popadyuk V.I., Kastyro I.V., Ganshin I.B., Vasyakova S.M.

More about the authors

Journal: Molecular Genetics, Microbiology and Virology. 2023;41(3): 43‑49

DOI: 10.17116/molgen20234103143

Read: 2369 times

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Table of contents

THE ROLE OF G1082A IL-10 POLYMORPHISM IN PHARYNGEAL TONSIL HYPERTROPHY
THE ROLE OF G1082A IL-10 POLYMORPHISM IN PHARYNGEAL TONSIL HYPERTROPHY

To cite this article:

Shilin SS, Emets YI, Spirin EA, et al. . The role of G1082A IL-10 polymorphism in pharyngeal tonsil hypertrophy. Molecular Genetics, Microbiology and Virology. 2023;41(3):43‑49. (In Russ.)
https://doi.org/10.17116/molgen20234103143

Подписка 2026 Молекулярная генетика, микробиология и вирусология (Molecular Genetics, Microbiology and Virology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

BACKGROUND

Hypertrophy of the pharyngeal tonsil (HPT) is considered one of the most common diseases of the ENT organs. The main purpose of this study was to study the polymorphism of the IL-10 (interleukin 10) gene and infections caused by human herpesviruses 6 (HHV6), cytomegalovirus (CMV) and Epstein-Barr virus (EBV) in children with HPT.

METHODS

The study included 106 children with hypertrophy of the pharyngeal tonsil and 38 healthy children aged 2 to 11 years. All children with pharyngeal amygdala hypertrophy were divided into three subgroups depending on the size of the pharyngeal amygdala. Viruses were determined by quantitative polymerase chain reaction (PCR) in real time using commercially available kits (QIAGEN, Germany). Patients with HPT were more likely to have HHV6 compared with CMV and EBV.

RESULTS

Among the three subgroups of children with HPT, HHV6 and EBV infections prevailed in children with the maximum degree of hypertrophy of the pharyngeal tonsil. The frequency of the GG genotype was higher in the control group of children. Significantly higher frequencies of the G allele and GG and GA genotypes for IL-10 rs1800896 were found in the subgroup of children with the smallest pharyngeal tonsil size compared to other subgroups. We suggested that infection with HHV6 and EBV may contribute to an increase in the size of the pharyngeal tonsil.

CONCLUSION

The IL-10 rs1800896 GG genotype may contribute to resistance to hypertrophy of the pharyngeal tonsil.

Keywords:

human herpes viruses 6 (HHV6)
human herpes virus 5 (CMV)
human herpes virus 4 (EBV)
rs1800896 Il-10
hypertrophy of the pharyngeal tonsil
children

Authors:

Shilin S.S.

Peoples’ Friendship University of Russia (RUDN University)

Emets Y.I.

Peoples’ Friendship University of Russia (RUDN University)

Spirin E.A.

Peoples’ Friendship University of Russia (RUDN University)

Gusev K.S.

Peoples’ Friendship University of Russia (RUDN University)

Antonyan A.A.

Peoples’ Friendship University of Russia (RUDN University)

Dolgonovskaya A.S.

Peoples’ Friendship University of Russia (RUDN University)

Piskarev D.V.

Peoples’ Friendship University of Russia (RUDN University)

Popadyuk V.I.

Peoples’ Friendship University of Russian

Kastyro I.V.

People’s Friendship University of Russia

Ganshin I.B.

Peoples’ Friendship University of Russia

Vasyakova S.M.

Peoples’ Friendship University of Russia (RUDN University)

Received:

14.10.2022

Accepted:

25.12.2022

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