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Shilin S.S.

Peoples’ Friendship University of Russia (RUDN University)

Emets Y.I.

Peoples’ Friendship University of Russia (RUDN University)

Spirin E.A.

Peoples’ Friendship University of Russia (RUDN University)

Gusev K.S.

Peoples’ Friendship University of Russia (RUDN University)

Antonyan A.A.

Peoples’ Friendship University of Russia (RUDN University)

Dolgonovskaya A.S.

Peoples’ Friendship University of Russia (RUDN University)

Piskarev D.V.

Peoples’ Friendship University of Russia (RUDN University)

Popadyuk V.I.

Peoples’ Friendship University of Russian

Kastyro I.V.

People’s Friendship University of Russia

Ganshin I.B.

Peoples’ Friendship University of Russia

Vasyakova S.M.

Peoples’ Friendship University of Russia (RUDN University)

The role of G1082A IL-10 polymorphism in pharyngeal tonsil hypertrophy

Authors:

Shilin S.S., Emets Y.I., Spirin E.A., Gusev K.S., Antonyan A.A., Dolgonovskaya A.S., Piskarev D.V., Popadyuk V.I., Kastyro I.V., Ganshin I.B., Vasyakova S.M.

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Journal: Molecular Genetics, Microbiology and Virology. 2023;41(3): 43‑49

DOI: 10.17116/molgen20234103143

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To cite this article:

Shilin SS, Emets YI, Spirin EA, et al. . The role of G1082A IL-10 polymorphism in pharyngeal tonsil hypertrophy. Molecular Genetics, Microbiology and Virology. 2023;41(3):43‑49. (In Russ.)
https://doi.org/10.17116/molgen20234103143

 
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BACKGROUND

Hypertrophy of the pharyngeal tonsil (HPT) is considered one of the most common diseases of the ENT organs. The main purpose of this study was to study the polymorphism of the IL-10 (interleukin 10) gene and infections caused by human herpesviruses 6 (HHV6), cytomegalovirus (CMV) and Epstein-Barr virus (EBV) in children with HPT.

METHODS

The study included 106 children with hypertrophy of the pharyngeal tonsil and 38 healthy children aged 2 to 11 years. All children with pharyngeal amygdala hypertrophy were divided into three subgroups depending on the size of the pharyngeal amygdala. Viruses were determined by quantitative polymerase chain reaction (PCR) in real time using commercially available kits (QIAGEN, Germany). Patients with HPT were more likely to have HHV6 compared with CMV and EBV.

RESULTS

Among the three subgroups of children with HPT, HHV6 and EBV infections prevailed in children with the maximum degree of hypertrophy of the pharyngeal tonsil. The frequency of the GG genotype was higher in the control group of children. Significantly higher frequencies of the G allele and GG and GA genotypes for IL-10 rs1800896 were found in the subgroup of children with the smallest pharyngeal tonsil size compared to other subgroups. We suggested that infection with HHV6 and EBV may contribute to an increase in the size of the pharyngeal tonsil.

CONCLUSION

The IL-10 rs1800896 GG genotype may contribute to resistance to hypertrophy of the pharyngeal tonsil.

Keywords:

human herpes viruses 6 (HHV6)
human herpes virus 5 (CMV)
human herpes virus 4 (EBV)
rs1800896 Il-10
hypertrophy of the pharyngeal tonsil
children

Authors:

Shilin S.S.

Peoples’ Friendship University of Russia (RUDN University)

Emets Y.I.

Peoples’ Friendship University of Russia (RUDN University)

Spirin E.A.

Peoples’ Friendship University of Russia (RUDN University)

Gusev K.S.

Peoples’ Friendship University of Russia (RUDN University)

Antonyan A.A.

Peoples’ Friendship University of Russia (RUDN University)

Dolgonovskaya A.S.

Peoples’ Friendship University of Russia (RUDN University)

Piskarev D.V.

Peoples’ Friendship University of Russia (RUDN University)

Popadyuk V.I.

Peoples’ Friendship University of Russian

Kastyro I.V.

People’s Friendship University of Russia

Ganshin I.B.

Peoples’ Friendship University of Russia

Vasyakova S.M.

Peoples’ Friendship University of Russia (RUDN University)

Received:

14.10.2022

Accepted:

25.12.2022

List of references:

  1. Scott SR, Darrow DH. Pediatric Otolaryngology; American Academy of Pediatrics: Washington, DC, USA, 2012. https://doi.org/10.1542/9781581107272
  2. Kozlov VS, Shilenkova VV, Karpov VA. Adenoids. Conservative and Surgical Treatment. M.: Polygraphist and Publisher; 2010. (In Russ.). https://www.elibrary.ru/item.asp?id=19552117
  3. Kim IA, Nosulya EV, Ragimova DR. Features of adherence to treatment of patients with chronic rhinosinusitis with nasal polyps. Vestnik Oto-Rino-Laringologii. 2022;87(1):81-86. (In Russ.). https://doi.org/10.17116/otorino20228701181
  4. Nosulya EV, Kim IA, Maksimov VA, Chernykh NM, Kravchuk AP. Frequency and variants of pneumatization of intranasal structures and their association with chronic sinusitis. Russian Rhinology. 2021;29(3):155-160. (In Russ.). https://doi.org/10.17116/rosrino202129031155
  5. Nosulya EV, Kunelskaya VYa, Kim IA, Luchsheva YuV, Kozulina IE. Efficacy and potential of olopatadine-mometasone combination nasal spray for the treatment of allergic rhinitis. Russian Rhinology. 2021;29(3):167-172. (In Russ.). https://doi.org/10.17116/rosrino202129031167
  6. Egorov VI, Golubeva OB, Vasilenko IA. Features of the dynamics of nasal breathing parameters in children with adenoiditis Head and neck. Russian Journal. 2022;10(2, suppl 2):87-90. (In Russ.). https://doi.org/10.25792/HN.2022.10.2.S2.87-90
  7. Kastyro IV, Reshetov IV, Popadyuk VI, Torshin VI, Ermakova NV, Karpukhina OV, et al. Studying the physiological effects of a new model of septoplasty in rats. Head and Neck. Russian Journal. 2020;8(2):33-38. (In Russ.). https://doi.org/10.25792/HN.2020.8.2.33-38
  8. Kastyro IV, Reshetov IV, Khamidulin GV, Shilin SS, Torshin VI, Kostyaeva MG, et al. Influence of Surgical Trauma in the Nasal Cavity on the Expression of p53 Protein in the Hippocampus of Rats. Doklady Biochemistry and Biophysics 2021;497(1):99-103. (In Russ.). https://doi.org/10.1134/S160767292102006X
  9. Dragunova SG, Reshetov IV, Kosyreva TF, Severin AE, Khamidulin GV, Shmaevsky PE, et al. Comparison of the Effects of Septoplasty and Sinus Lifting Simulation in Rats on Changes in Heart Rate Variability. Doklady Biochemistry and Biophysics. 2021;498(1):165-169. (In Russ.). https://doi.org/10.1134/S1607672921030029
  10. Torshin VI, Kastyro IV, Reshetov IV, Kostyaeva MG, Popadyuk VI. The Relationship between p53-Positive Neurons and Dark Neurons in the Hippocampus of Rats after Surgical Interventions on the Nasal Septum. Dokl Biochem Biophys. 2022;502(1):37-42. (In Russ.). https://doi.org/10.1134/S1607672922010094
  11. Demyashkin GA, Kastyro IV, Sidorin AV, Borisov YS. The specific immunophenotypic features of nasopharyngeal carcinoma. Vestn Otorinolaringol. 2018;83(5):40-44. (In Russ.). https://doi.org/10.17116/otorino20188305140
  12. Kastyro IV, Romanko YuS, Muradov GM, Popadyuk VI, Kalmykov IK, Kostyaeva MG, et al. Photobiomodulation of acute pain syndrome after septoplasty. Biomedical Photonics. 2021;10(2):34-41. (In Russ.). https://doi.org/10.24931/2413-9432-2021-10-2-34-41
  13. Kastyro IV, Torshin VI, Drozdova GA, Popadyuk VI. Acute pain intensity in men and women after septoplasty. Russian Open Medical Journal. 2017;6(3):1-6.  https://doi.org/10.15275/rusomj.2017.0305
  14. Kastyro IV, Popadyuk VI, Muradov GM, Reshetov IV. Low-Intensity Laser Therapy As a Method to Reduce Stress Responses after Septoplasty. Dokl Biochem Biophys. 2021;500(1): 300-303. (In Russ.). https://doi.org/10.1134/S1607672921050112
  15. Popadyuk VI, Kastyro IV, Ermakova NV, Torshin VI. Septoplasty and tonsillectomy: acute stress response as a measure of effectiveness of local anesthetics. Vestn Otorinolaringol. 2016;81(3):7-11. (In Russ.). https://doi.org/10.17116/otorino20168137-11
  16. Marseglia G, Caimmi D, Pagella F, Matti E, Labò E, Licari A, et al. Adenoids during Childhood: The Facts. Int. J Immunopathol Pharmacol. 2011;24(suppl 4):1-5.  https://doi.org/10.1177/03946320110240S401
  17. Boyaka PN, Wright PF, Marinaro M, Kiyono H, Johnson JE, Gonzales RA, et al. Human Nasopharyngeal-Associated Lymphoreticular Tissues: Functional Analysis of Subepithelial and Intraepithelial B and T Cells from Adenoids and Tonsils. Am J Pathol 2000;157:2023-2035. https://doi.org/10.1016/S0002-9440(10)64841-9
  18. Valsecchi C, Tagliacarne SC, Brambilla I, Klersy C, Benazzo M, Montagna L, et al. Detection of IL10-producing B cell (B10) in adenoids of atopic children with adenoidal hypertrophy. Ital J Pediatr. 2018;44:30.  https://doi.org/10.1186/s13052-018-0471-3
  19. Diehl S, Rincón M. The two faces of IL-6 on Th1/Th2 differentiation. Mol Immunol. 2002;39:531-536.  https://doi.org/10.1016/S0161-5890(02)00210-9
  20. Komorowska A, Komorowski J, Banasik M, Lewkowicz P, Tchórzewski H. Cytokines locally produced by lymphocytes removed from the hypertrophic nasopharyngeal and palatine tonsils. Int J Pediatr Otorhinolaryngol. 2005;69:937-941.  https://doi.org/10.1016/j.ijporl.2005.01.035
  21. Groux H, Cottrez F. The complex role of interleukin-10 in autoimmunity. J Autoimmun. 2004;20:281-285.  https://doi.org/10.1016/S0896-8411(03)00044-1
  22. Lévy Y, Brouet JC. Interleukin-10 prevents spontaneous death of germinal center B cells by induction of the bcl-2 protein. J Clin Investig. 1994;93:424-428.  https://doi.org/10.1172/JCI116977
  23. Marcano-Acuña ME, Carrasco-Llatas M, Tortajada-Girbés M, Dalmau-Galofre J, Codoñer-Franch P. Impact of adenotonsillectomy on the evolution of inflammatory markers. Clin Otolaryngol. 2019;44:983-988.  https://doi.org/10.1111/coa.13423
  24. Turner DM, Williams DM, Sankaran D, Lazarus M, Sinnott PJ, Hutchinson IV. An Investigation of Polymorphism in the Interleukin-10 Gene Promoter. Eur J Immunogenet. 1997;24:1-8.  https://doi.org/10.1111/j.1365-2370.1997.tb00001.x
  25. Chagas CA, Endo LH, Sakano E, Pinto GA, Brousset P, Vassallo J. Detection of herpesvirus type 8 (HHV8) in children’s tonsils and adenoids by immunohistochemistry and in situ hybridization. Int J Pediatr Otorhinolaryngol. 2006;70:65-72.  https://doi.org/10.1016/j.ijporl.2005.04.030
  26. Silvoniemi A, Mikola E, Ivaska L, Jeskanen M, Löyttyniemi E, Puhakka T, et al. Intratonsillar detection of 27 distinct viruses: A cross-sectional study. J Med Virol. 2020;92:3830-3838. https://doi.org/10.1002/jmv.26245
  27. Davison AJ. Comparative analysis of the genomes. In Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis; Cambridge University Press: Cambridge, UK; 2007. https://doi.org/10.1017/CBO9780511545313.003
  28. Riaz A, Murtaz-ul-Hasan K, Akhtar N. Recent understanding of the classification and life cycle of herpesviruses: A review. Sci Lett. 2017;5:195-207. 
  29. Sehrawat S, Kumar D, Rouse BT, Sehrawat S, Kumar D, Rouse BT. Herpesviruses: Harmonious Pathogens but Relevant Cofactors in Other Diseases? Front Cell Infect Microbiol. 2018;8:177.  https://doi.org/10.3389/fcimb.2018.00177
  30. Wang X, Yang F, Xu G, Zhong S. The roles of IL-6, IL-8 and IL-10 gene polymorphisms in gastric cancer: A meta-analysis. Cytokine. 2018;111:230-236.  https://doi.org/10.1016/j.cyto.2018.08.024
  31. Seifart C, Plagens A, Dempfle A, Clostermann U, Vogelmeier C, Von Wichert P, Seifart U. TNF-α, TNF-β, IL-6, and IL-10 Polymorphisms in Patients with Lung Cancer. Dis Markers. 2005;21:157-165.  https://doi.org/10.1111/j.1399-0039.2005.00343.x
  32. Bandil K, Singhal P, Dogra A, Bharadwaj M, Rawal SK, Doval DC, Varshney AK. Association of SNPs/haplotypes in promoter of TNF A and IL-10 gene together with life style factors in prostate cancer progression in Indian population. Agents Actions. 2017;66:1085-1097. https://doi.org/10.1007/s00011-017-1088-5
  33. Hong P, Feng W-Y, Fu L-H, Jin J, Fu J-P. Associations between genetic polymorphisms in interleukin-10 and hematological oncology: Evidence from a meta-analysis. Cancer Biol Ther. 2020;21:372-378.  https://doi.org/10.1080/15384047.2019.1702404
  34. Yaghobi R, Alizadeh F, Khodavandi A. Interaction between Herpes Virus Infections and IL10 and Risk of Bone Marrow Suppression. Int J Organ Transplant Med. 2018;9:119-125. 
  35. Haanpää M, Nurmikko T, Hurme M. Polymorphism of the IL-10 gene is associated with susceptibility to herpes zoster. Scand J Infect Dis. 2002;34:112-114.  https://doi.org/10.1080/00365540110077218
  36. Josephson GD, Duckworth L, Hossain J. Proposed definitive grading system tool for the assessment of adenoid hyperplasia. Laryngoscope. 2011;121:-187-193.  https://doi.org/10.1002/lary.21215
  37. Saedi B, Sadeghi M, Mojtahed M, Mahboubi H. Diagnostic efficacy of different methods in the assessment of adenoid hypertrophy. Am J Otolaryngol. 2011;32:147-151.  https://doi.org/10.1016/j.amjoto.2009.11.003
  38. Pathak K, Ankale NR, Harugop AS. Comparison between Radiological versus Endoscopic Assessment of Adenoid Tissue in Patients of Chronic Adenoiditis. Indian J Otolaryngol Head Neck Surg Off Publ Assoc Otolaryngol India. 2019;71(suppl 1):981-985.  https://doi.org/10.1007/s12070-019-01669-z
  39. Fujioka M, Young LW, Girdany BR. Radiographic evaluation of adenoidal size in children: Adenoidal-nasopharyngeal ratio. Am J Roentgenol. 1979;133:401-404.  https://doi.org/10.2214/ajr.133.3.401
  40. Huang C-C, Wu P-W, Chen C-L, Wang C-H, Lee T-J, Tsai C-N, Chiu C-H. IL-17A expression in the adenoid tissue from children with sleep disordered breathing and its association with pneumococcal carriage. Sci Rep. 2018;8:16770. https://doi.org/10.1056/nejmoa1911303
  41. Mlynarek A, Tewfik MA, Hagr A, Manoukian JJ, Schloss MD, Tewfik TL, Choi-Rosen J. Lateral Neck Radiography versus Direct Video Rhinoscopy in Assessing Adenoid Size. J Otolaryngol. 2004;33:360-365.  https://doi.org/10.2310/7070.2004.03074
  42. Chen J, Longnecker R. Epithelial cell infection by Epstein—Barr virus. FEMS Microbiol Rev. 2019;43:674-683.  https://doi.org/10.1093/femsre/fuz023
  43. Chen S-J, Wang S-C, Chen Y-C. Antiviral Agents as Therapeutic Strategies Against Cytomegalovirus Infections. Viruses. 2019;12:21.  https://doi.org/10.3390/v12010021
  44. Kondo K, Yamanishi K. HHV-6A, 6B, and 7: Molecular basis of latency and reactivation. In Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis; Cambridge University Press: Cambridge, UK; 2007.
  45. Mori Y. Recent topics related to human herpesvirus 6 cell tropism. Cell Microbiol. 2009;11:1001-1006. https://doi.org/10.1111/j.1462-5822.2009.01312.x
  46. Karlidağ T, Bulut Y, Keleş E, Alpay HC, Seyrek A, Orhan İ, et al. Presence of herpesviruses in adenoid tissues of children with adenoid hypertrophy and chronic adenoiditis. Turk J Ear Nose Throat. 2012;22:32-37. 
  47. Pokrovskaya EM, Khaliullina SV, Anokhin VA, Khaliullina KR, Khaertinov KS, Krasnozhen VN, Viktorova KS. Optimization of treatment of lymphopharyngeal ring organ hypertrophy in children infected with herpes viruses. Pract Med. 2020;18:6.  https://doi.org/10.32000/2072-1757-2020-6-133-137
  48. Sato M, Li H, Ikizler MR, Werkhaven JA, Williams JV, Chappell JD, et al. Detection of Viruses in Human Adenoid Tissues by Use of Multiplex PCR. J Clin Microbiol. 2009;47:771-773.  https://doi.org/10.1128/JCM.02331-08
  49. Endo LH, Sakano E, Camargo LA, Ferreira DR, Pinto GA, Vassallo J. Detection of Epstein—Barr virus in children’s adenoids by in situ hybridization. Int Congr Series. 2003;1257:157-160.  https://doi.org/10.1016/S0531-5131(03)01160-9
  50. Park SJ, Cho JW, Lee KS. Single nucleotide polymorphisms of interleukin-10 promoter gene in Korean herpes zoster patients. Korean J Dermatol. 2006;44:1325-1331.
  51. Jiang L, Wu XJ, Huang JB, Chen C, Xu HG, Xue HM. Relationship between Single Nucleotide Polymorphisms of IL2RA, IL-10 Gene and Epstein-Barr Virus Associated Hemophagocytic Lymphohistiocytosisin in children. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2020;28:646-651. 
  52. Mehmet Ali B, Özdaş T, Özdaş S. The common genetic variants of toll-like receptor and susceptibility to adenoid hypertrophy: A hospital-based cohort study. Turk J Med Sci. 2016;46:1449-1458. https://doi.org/10.3906/sag-1511-16
  53. Atilla MH, Özdaş S, Özdaş T, Baştimur S, Muz SE, Öz I, et al. Association of Ugrp2 gene polymorphisms with adenoid hypertrophy in the pediatric population. Braz J Otorhinolaryngol. 2018;84:599-607.  https://doi.org/10.1016/j.bjorl.2017.07.004
  54. Shabaldina EV, Shabaldin AV, Riazantsev SV, Simbirtsev SV. The role of cytokine gene polymorphisms in the development of hypertrophy of the tonsils of the lymphoid pharyngeal ring and atopic march in the children. Vestn Otorinolaringol. 2013;6:18-23. 
  55. Lomaeva I, Aghajanyan A, Dzhaparidze L, Gigani OB, Tskhovrebova LV, Gigani OO, Popadyuk VI. Adenoid Hypertrophy Risk in Children Carriers of G-1082A Polymorphism of IL-10 Infected with Human Herpes Virus (HHV6, EBV, CMV). Life (Basel). 2022;12(2):266.  https://doi.org/10.3390/life12020266

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