Physicians’ adherence to clinical guidelines: impact on mortality in the treatment of solid tumors (a systematic review and meta-analysis)

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OBJECTIVE

To analyze the impact of physicians’ adherence to clinical guidelines on treatment outcomes in patients with solid tumors.

MATERIAL AND METHODS

Two independent researchers searched and selected reports for systematic review in two databases using secondary literature sources. Meta-analysis was performed using RevMan v.5.3 software. Mortality rate, 1- and 5-year survival were the main endpoints.

RESULTS

A systematic review included 15 studies and 239.350 patients. There were 6 studies devoted to breast cancer and 4 studies in gynecological oncology. All studies were retrospective. Meta-analysis of mortality (9 studies) and 5-year survival (9 studies) revealed significant benefits for patients treated in accordance with clinical guidelines. Analysis of 1-year survival (3 studies) did not demonstrate such results.

CONCLUSION

Physicians’ adherence to clinical guidelines reduces the mortality rate of patients with cancer.

Keywords:

clinical guidelines

cancer care

mortality from cancer

survival of cancer patients

solid tumors

Authors:

Ledovskikh Yu.A.

Center for Expertise and Quality Control of Medical Care;
Semashko National Research Institute of Public Health;
Russian Medical Academy of Continuing Professional Education

ORCID: 0000-0002-7567-6027

Fedyaeva V.K.

Center for Expertise and Quality Control of Medical Care;
Russian Medical Academy of Continuing Professional Education

SPIN RSCI: 7202-4371
ORCID: 0000-0002-7730-1237

Received:

28.02.2024

Accepted:

28.02.2024

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