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Warnick G.R.

Berkeley Heart Lab

Kimberly M.M.

Centers for Disease Control and Prevention

Waymack P.P.

Centers for Disease Control and Prevention

Leary E.T.

Pacific Biometrics Inc.

Myers G.L.

Myers Consulting, Smyrna

Standardization of measurements for cholesterol, triglycerides, and major lipoproteins

Authors:

Warnick G.R., Kimberly M.M., Waymack P.P., Leary E.T., Myers G.L.

More about the authors

Journal: Laboratory Service. 2021;10(3): 43‑57

DOI: 10.17116/labs20211003143

Views: 3997

Downloaded: 184

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Table of contents

STANDARDIZATION OF MEASUREMENTS FOR CHOLESTEROL, TRIGLYCERIDES, AND MAJOR LIPOPROTEINS
STANDARDIZATION OF MEASUREMENTS FOR CHOLESTEROL, TRIGLYCERIDES, AND MAJOR LIPOPROTEINS

To cite this article:

Warnick GR, Kimberly MM, Waymack PP, Leary ET, Myers GL. Standardization of measurements for cholesterol, triglycerides, and major lipoproteins. Laboratory Service. 2021;10(3):43‑57. (In Russ.)
https://doi.org/10.17116/labs20211003143

Подписка 2025-2 (Laboratory Service)
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This review evaluates the status of standardization of lipids and lipoproteins. Prerequisites and some basic principles for standardization are provided. The reference systems for cholesterol, HDL cholesterol (HDL-C), LDL cholesterol (LDL-C), triglycerides (TG), apolipoprotein A-I (apoA-I), apolipoprotein B (apoB), and lipoprotein(a) (Lp[a]) are described. Brief descriptions of the standardization programs available for each of these analytes are also provided. Finally, the review addresses some of the challenges in standardizing these markers of cardiovascular disease (CVD). The standardization programs described have contributed to improvements in laboratory measurements of lipids and lipoproteins. Our intention is that clinical laboratory professionals and manufacturers of in vitro diagnostics will use these resources to standardize lipid and lipoprotein measurements. Manufacturers must take the initiative to thoroughly evaluate their products and ensure traceability to the reference systems.

Keywords:

ldl cholesterol lipoproteins
high density lipoprotein cholesterol
triglycerides
lipoproteins
cardiovascular diseases
cholesterol
apolipoprotein B
apolipoprotein A1
lipids
in vitro diagnostics

Authors:

Warnick G.R.

Berkeley Heart Lab

Kimberly M.M.

Centers for Disease Control and Prevention

Waymack P.P.

Centers for Disease Control and Prevention

Leary E.T.

Pacific Biometrics Inc.

Myers G.L.

Myers Consulting, Smyrna

Received:

17.06.2021

Accepted:

23.08.2021

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