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Pigarova E.A.

Endocrinology Research Centre

Povaliaeva A.A.

Endocrinology Research Centre

Dzeranova L.K.

Endocrinology Research Centre

Rozhinskaya L.Ya.

Endocrinology Research Centre

The role of vitamin D in endocrine diseases

Authors:

Pigarova E.A., Povaliaeva A.A., Dzeranova L.K., Rozhinskaya L.Ya.

More about the authors

Journal: Laboratory Service. 2021;10(2): 34‑46

Read: 33065 times


To cite this article:

Pigarova EA, Povaliaeva AA, Dzeranova LK, Rozhinskaya LYa. The role of vitamin D in endocrine diseases. Laboratory Service. 2021;10(2):34‑46. (In Russ.)
https://doi.org/10.17116/labs20211002134

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References:

  1. Pigarova E.A., Povalyaeva A.A., Dzeranova L.K., Rozhinskaya L.Ya. The role of vitamin D in the prevention and treatment of rickets in children. Pediatrics. Consilium Medicum. 2019.No. 3.P. 40-45. (In Russ.)
  2. Pigarova E.A., Petrushkina A.A. Non-classical effects of vitamin D. Osteoporosis and Bone Diseases. 2017;20(3):90-101. (In Russ.) https://doi.org/10.14341/osteo2017390-101
  3. Wang T-T, Tavera-Mendoza LE, Laperriere D, Libby E, MacLeod NB, Nagai Y, Bourdeau V, Konstorum A, Lallemant B, Zhang R, Mader S, White JH. Large- scale in silico and microarray-based identification of Direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005;19(11):2685-2695.
  4. Pigarova E.A., Rozhinskaya L.Ya., Belaya Zh.E., Dzeranova L.K., Karonova T.L., Ilyin A.V., Melnichenko G.A., Dedov I.I. Russian Association of Endocrinologists recommendations for diagnosis, treatment and prevention of vitamin D deficiency in adults. Problems of Endocrinology. 2016; 62(4):60-84. (In Russ.) https://doi.org/10.14341/probl201662460-84
  5. Lesnyak O.M., Nikitinskaya O.A., Toroptsova N.V., Belaya Zh.E., Belova K.Yu., Bordakova E.V., Gilmanov A.Zh., Gurkina E.Yu., Dorofeikov V.V., Ershova O.B., Zazerskaya I.E., Zotkin E.G., Karonova T.L., Marchenkova L.A., Nazarova A.V., Pigarova E.A., Rozhinskaya L.Ya., Safonova Yu.A., Skripnikova I.A., Shirinyan L.V., Yureneva S.V., Yakushevskaya O.V. The prevention, diagnosis, and treatment of vitamin D and calcium deficiencies in the adult population of Russia and in patients with osteoporosis (according to the materials of prepared clinical recommendations). Rheumatology Science and Practice. 2015;53(4):403-408. (In Russ.) https://doi.org/10.14412/1995-4484-2015-403-408
  6. Povaliaeva A.A., Pigarova E.A., Dzeranova L.K., Rozhinskaya L.Ya., Mel’nichenko G.A. Vitamin D metabolism in hypercorticism and acromegaly. Problems of Endocrinology. 2019;65(6):444-450. (In Russ.) https://doi.org/10.14341/probl12099
  7. Prietl B, Treiber G, Pieber TR, Amrein K. Vitamin D and immune function. Nutrients. 2013;5:2502-2521. https://doi.org/10.3390/nu5072502
  8. Hewison M, Burke F, Evans KN, Lammas DA, Sansom DM, Liu P, Modlin RL, Adams JS. Extra-renal 25-hydroxyvitamin D3-1a-hydroxylase in human health and Disease. J Steroid Biochem Mol Biol. 2007;103(3-5):316-321. 
  9. Kmieć P, Sworczak K. Vitamin D in thyroid Disorders. Exp Clin Endocrinol Diabetes. 2015;123:386-393.  https://doi.org/10.1055/s-0035-1554714
  10. Kim D. The Role of Vitamin D in Thyroid Diseases. Int J Mol Sci. 2017;18(9):1949. Published 2017 Sep 12.  https://doi.org/10.3390/ijms18091949
  11. Pigarova E.A., Plescheva A.V., Dzeranova L.K. The effect of vitamin D on the immune system. Immunology . 2015. T. 36. No. 1. S. 62-66. 
  12. Wacker M, Holick MF. Vitamin D — Effects on skeletal and extraskeletal health and the need for supplementation. Nutrients. 2013;5:111-148.  https://doi.org/10.3390/nu5010111
  13. Binkley N, Dawson-Hughes B, Durazo-Arvizu R, Thamm M, Tian L, Merkel JM, Jones JC, Carter GD, Sempos CT. Vitamin D measurement standardization: The way out of the chaos. J Steroid Biochem Mol Biol. 2017;173:117-121.  https://doi.org/10.1016/j.jsbmb.2016.12.002
  14. Binkley N, Carter GD. Toward Clarity in Clinical Vitamin D Status Assessment: 25(OH)D Assay Standardization. Endocrinol Metab Clin N Am. 2017;46(4):885-899.  https://doi.org/10.1016/j.ecl.2017.07.012
  15. Durazo-Arvizu RA, Tian L, Brooks SPJ, Sarafin K, Cashman KD, Kiely M, Merkel J, Myers GL, Coates PM, Sempos CT. The Vitamin D Standardization Program (VDSP) Manual for Retrospective Laboratory Standardization of Serum 25-Hydroxyvitamin D Data. J AOAC Int. 2017;100(5):1234-1243. https://doi.org/10.5740/jaoacint.17-0196
  16. Cashman KD, Dowling KG, Škrabáková Z, Gonzalez-Gross M, Valtueña J, De Henauw S, Moreno L, Damsgaard CT, Michaelsen KF, Mølgaard C, Jorde R, Grimnes G, Moschonis G, Mavrogianni C, Manios Y, Thamm M, Mensink GB, Rabenberg M, Busch MA, Cox L, Meadows S, Goldberg G, Prentice A, Dekker JM, Nijpels G, Pilz S, Swart KM, van Schoor NM, Lips P, Eiriksdottir G, Gudnason V, Cotch MF, Koskinen S, Lamberg-Allardt C, Durazo-Arvizu RA, Sempos CT, Kiely M. Vitamin D Deficiency in Europe: pandemic? Am J Clin Nutr. 2016;103(4):1033-1044. https://doi.org/10.3945/ajcn.115.120873
  17. Heijboer AC, Blankenstein MA, Kema IP, Buijs MM. Accuracy of 6 routine 25-hydroxyvitamin D assays: influence of vitamin D binding protein concentration. Clin Chem. 2012;58(3):543-548.  https://doi.org/10.1373/clinchem.2011.176545
  18. Mumford SL, Garbose RA, Kim K, Kissell K, Kuhr DL, Omosigho UR, Perkins NJ, Galai N, Silver RM, Sjaarda LA, Plowden TC, Schisterman EF. Association of preconception serum 25-hydroxyvitamin D concentrations with livebirth and pregnancy loss: a prospective cohort study. Lancet Diabetes Endocrinol. 2018;6(9):725-732.  https://doi.org/10.1016/S2213-8587(18)30153-0
  19. Wan LY, Zhang YQ, Chen MD, Liu CB, Wu JF. Relationship of structure and function of DNA-binding Domain in vitamin D receptor. Molecules. 2015;20:12389-12399. https://doi.org/10.3390/molecules200712389
  20. Caprio M, Infante M, Calanchini M, Mammi C, Fabbri A. Vitamin D: Not just the bone. Evidence for beneficial pleiotropic extraskeletal effects. Eat Weight Disord. 2017;22:27-41.  https://doi.org/10.1007/s40519-016-0312-6
  21. Saccone D, Asani F, Bornman L. Regulation of the vitamin D receptor gene by environment, genetics and epigenetics. Gene. 2015;561:171-180.  https://doi.org/10.1016/j.gene.2015.02.024
  22. Rochel N, Molnár F. Structural aspects of Vitamin D endocrinology. Mol Cell Endocrinol. 2017;453:22-35.  https://doi.org/10.1016/j.mce.2017.02.046
  23. Saponaro F, Saba A, Zucchi R. An Update on Vitamin D Metabolism. Int J Mol Sci. 2020;21(18):6573. Published 2020 Sep 8.  https://doi.org/10.3390/ijms21186573
  24. Carlberg C. Molecular endocrinology of vitamin D on the epigenome level. Mol Cell Endocrinol. 2017;453:14-21.  https://doi.org/10.1016/j.mce.2017.03.016
  25. Narchi H, El Jamil M, Kulaylat N. Symptomatic rickets in adolescence. Arch Dis Child. 2001;84(6):501-503. 
  26. Пигарова Е.А., Мазурина Н.В., Трошина Е.А. Витамин D в профилактике костных и метаболических нарушений. Consilium Medicum. 2019;21:4:84-90. 
  27. Golden NH, Abrams SA, Committee on Nutrition Optimizing bone health in children and adolescents. Pediatrics. 2014;134(4):1229-1243.
  28. Winzenberg T, Jones G. Vitamin D and bone health in childhood and adolescence. Calcif Tissue Int. 2013;92(2):140-150. 
  29. Bhattoa HP, Konstantynowicz J, Laszcz N, Wojcik M, Pludowski P. Vitamin D: musculoskeletal health. Rev Endocr Metab Disord. 2017;18(3):363-371. 
  30. Gordon CM, Zemel BS, Wren TA, Leonard MB, Bachrach LK, Rauch F, et al. The Determinants of peak bone mass. J Pediatr. 2017;180:261-269. 
  31. Rader CP, Corsten N, Rolf O. Osteomalacia and vitamin D Deficiency. Orthopade. 2015;44:695-702.  https://doi.org/10.1007/s00132-015-3141-9
  32. Priemel M, von Domarus C, Klatte TO, Kessler S, Schlie J, Meier S, et al. Bone mineralization Defects and vitamin D Deficiency: histomorphometric analysis of iliac crest bone biopsies and circulating 25-hydroxyvitamin D in 675 patients. J Bone Miner Res. 2010;25:305-312. 
  33. Cauley JA, Lacroix AZ, Wu L, Horwitz M, Danielson ME, Bauer DC, et al. Serum 25-hydroxyvitamin D concentrations and risk for hip fractures. Ann Intern Med. 2008;149:242-250. 
  34. van Schoor NM, Visser M, Pluijm SM, Kuchuk N, Smit JH, Lips P. Vitamin D Deficiency as a risk factor for osteoporotic fractures. Bone. 2008;42:260-266. 
  35. Bischoff-Ferrari HA, Willett WC, Wong JB, Stuck AE, Staehelin HB, Orav EJ, et al. Prevention of nonvertebral fractures with oral vitamin D and Dose Dependency: a meta-analysis of randomized controlled trials. Arch Intern Med. 2009;169:551-561. 
  36. Bischoff-Ferrari HA, Willett WC, Orav EJ, Lips P, Meunier PJ, Lyons RA, et al. A pooled analysis of vitamin D Dose requirements for fracture prevention. New Engl J Med. 2012;367:40-49. 
  37. Makinen M, Mykkanen J, Koskinen M, Simell V, Veijola R, Hyoty H, Ilonen J, Knip M, Simell O, Toppari J. Serum 25-Hydroxyvitamin D Concentrations in Children Progressing to Autoimmunity and Clinical Type 1 Diabetes. J Clin Endocrinol Metab. 2016;101:723-729.  https://doi.org/10.1210/jc.2015-3504
  38. Granfors M, Augustin H, Ludvigsson J, Brekke HK. No association between use of multivitamin supplement containing vitamin D During pregnancy and risk of Type 1 Diabetes in the child. Pediatr Diabetes. 2016;17:525-530.  https://doi.org/10.1111/pedi.12334
  39. Wood JR, Connor CG, Cheng P, Ruedy KJ, Tamborlane WV, Klingensmith G, Schatz D, Gregg B, Cengiz E, Willi S, et al. Vitamin D status in youth with type 1 and type 2 diabetes enrolled in the Pediatric Diabetes Consortium (PDC) is not worse than in youth without Diabetes. Pediatr Diabetes. 2016;17:584-591.  https://doi.org/10.1111/pedi.12340
  40. Povaliaeva AA, Pigarova EA, Dzeranova LK, Rozhinskaya LY. The relationship of vitamin D status with the development and course of diabetes mellitus type 1. Obesity and metabolism. 2020;17(4):82-87. doi: https://doi.org/10.14341/omet12206
  41. Marino R, Misra M. Extra-Skeletal Effects of Vitamin D. Nutrients. 2019;11(7):1460. Published 2019 Jun 27.  https://doi.org/10.3390/nu11071460
  42. Cooper JD, Smyth DJ, Walker NM, Stevens H, Burren OS, Wallace C, Greissl C, Ramos-Lopez E, Hypponen E, Dunger DB, et al. Inherited variation in vitamin D genes is associated with predisposition to autoimmune Disease type 1 diabetes. Diabetes. 2011;60:1624-1631. https://doi.org/10.2337/db10-1656
  43. Sahin OA, Goksen D, Ozpinar A, Serdar M, Onay H. Association of vitamin D receptor polymorphisms and type 1 diabetes susceptibility in children: A meta-analysis. Endocr Connect. 2017;6:159-171.  https://doi.org/10.1530/EC-16-0110
  44. Kodama K, Zhao Z, Toda K, Yip L, Fuhlbrigge R, Miao D, Fathman CG, Yamada S, Butte AJ, Yu L. Expression-Based Genome-Wide Association Study Links Vitamin D-Binding Protein with Autoantigenicity in Type 1 Diabetes. Diabetes. 2016;65:1341-1349. https://doi.org/10.2337/db15-1308
  45. Zipitis CS, Akobeng AK. Vitamin D supplementation in early childhood and risk of type 1 diabetes: A systematic review and meta-analysis. Arch Dis Child. 2008;93:512-517.  https://doi.org/10.1136/adc.2007.128579
  46. Deda L, Yeshayahu Y, Sud S, Cuerden M, Cherney DZ, Sochett EB, Mahmud FH. Improvements in peripheral vascular function with vitamin D treatment in Deficient adolescents with type 1 diabetes. Pediatr Diabetes. 2018;19:457-463.  https://doi.org/10.1111/pedi.12595
  47. Gabbay MA, Sato MN, Finazzo C, Duarte AJ, Dib SA. Effect of cholecalciferol as adjunctive therapy with insulin on protective immunologic profile and Decline of residual beta-cell function in new-onset type 1 diabetes mellitus. Arch Pediatr Adolesc Med. 2012;166:601-607.  https://doi.org/10.1001/archpediatrics.2012.164
  48. Treiber G, Prietl B, Frohlich-Reiterer E, Lechner E, Ribitsch A, Fritsch M, Rami-Merhar B, Steigleder-Schweiger C, Graninger W, Borkenstein M, et al. Cholecalciferol supplementation improves suppressive capacity of regulatory T-cells in young patients with new-onset type 1 diabetes mellitus — A randomized clinical trial. Clin Immunol. 2015;161:217-224.  https://doi.org/10.1016/j.clim.2015.08.002
  49. Silvis K, Aronsson CA, Liu X, Uusitalo U, Yang J, Tamura R, Lernmark A, Rewers M, Hagopian W, She JX, et al. Maternal Dietary supplement use and Development of islet autoimmunity in the offspring: TEDDY study. Pediatr Diabetes. 2019;20:86-92.  https://doi.org/10.1111/pedi.12794
  50. Perchard R, Magee L, Whatmore A, Ivison F, Murray P, Stevens A, Mughal MZ, Ehtisham S, Campbell J, Ainsworth S, et al. A pilot interventional study to evaluate the impact of cholecalciferol treatment on HbA1c in type 1 diabetes (T1D) Endocr. Connect. 2017;6:225-231.  https://doi.org/10.1530/EC-17-0045
  51. Sharma S, Biswal N, Bethou A, Rajappa M, Kumar S, Vinayagam V. Does Vitamin D Supplementation Improve Glycaemic Control in Children with Type 1 Diabetes Mellitus? — A Randomized Controlled Trial. J Clin Diagn Res. 2017;11:SC15. https://doi.org/10.7860/JCDR/2017/27321.10645
  52. Earthman CP, Beckman LM, Masodkar K, Sibley SD. The link between obesity and low circulating 25-hydroxyvitamin D concentrations: considerations and implications. Int J Obes. 2012;36(3):387-396.  https://doi.org/10.1038/ijo.2011.119
  53. Ding C, Gao D, Wilding J, Trayhurn P, Bing C. Vitamin D signalling in adipose tissue. Br J Nutr. 2012;108(11):1915-1923. https://doi.org/10.1017/S0007114512003285.
  54. Giustina A, Adler RA, Binkley N, et al. Consensus statement from 2nd International Conference on Controversies in Vitamin D. Rev Endocr Metab Disord. 2020;21(1):89-116.  https://doi.org/10.1007/s11154-019-09532-w
  55. Roth CL, Elfers CT, Figlewicz DP, Melhorn SJ, Morton GJ, Hoofnagle A, Yeh MM, Nelson JE, Kowdley KV. Vitamin D Deficiency in obese rats exacerbates nonalcoholic fatty liver Disease and increases hepatic resistin and Toll-like receptor activation. Hepatology. 2012;55(4):1103-1111. https://doi.org/10.1002/hep.24737
  56. Calton EK, Keane KN, Newsholme P, Zhao Y, Soares MJ. The impact of cholecalciferol supplementation on the systemic inflammatory profile: a systematic review and meta-analysis of high-quality randomized controlled trials. Eur J Clin Nutr. 2017;71(8):931-943.  https://doi.org/10.1038/ejcn.2017.67
  57. Correa-Rodriguez M, Carrillo-Avila JA, Schmidt-RioValle J, Gonzalez-Jimenez E, Vargas S, Martin J, Rueda-Medina B. Genetic association analysis of vitamin D receptor gene polymorphisms and obesity-related phenotypes. Gene. 2018;640:51-56.  https://doi.org/10.1016/j.gene.2017.10.029
  58. Smotkin-Tangorra M, Purushothaman R, Gupta A, Nejati G, Anhalt H, Ten S. Prevalence of vitamin D insufficiency in obese children and adolescents. J Pediatr Endocrinol Metab. 2007;20:817-823.  https://doi.org/10.1515/JPEM.2007.20.7.817
  59. Walsh JS, Bowles S, Evans AL. Vitamin D in obesity. Curr Opin Endocrinol Diabetes Obes. 2017;24(6):389-394. PMID: 28915134. https://doi.org/10.1097/MED.0000000000000371
  60. Khandalavala BN, Hibma PP, Fang X. Prevalence and persistence of vitamin D Deficiency in biliopancreatic Diversion patients: a retrospective study. Obes Surg. 2010;20(7):881-884.  https://doi.org/10.1007/s11695-010-0185-0
  61. Alvarez JA, Ashraf A. Role of vitamin D in insulin secretion and insulin sensitivity for glucose homeostasis. Int J Endocrinol. 2010;2010:351385. https://doi.org/10.1155/2010/351385
  62. Al-Shoumer KA, Al-Essa TM. Is there a relationship between vitamin D with insulin resistance and Diabetes mellitus? World J Diabetes. 2015;6(8):1057-1064. https://doi.org/10.4239/wjd.v6.i8.1057
  63. Song Y, Wang L, Pittas AG, Del Gobbo LC, Zhang C, Manson JE, Hu FB. Blood 25-hydroxy vitamin D levels and incident type 2 diabetes: a meta-analysis of prospective studies. Diabetes Care. 2013;36(5):1422-1428. https://doi.org/10.2337/dc12-0962
  64. Omar DF, Kamal MM, El-Hefnawy MH, El-Mesallamy HO. Serum Vitamin D and Its Upregulated Protein, Thioredoxin Interacting Protein, Are Associated With Beta-Cell Dysfunction in Adult Patients With Type 1 and Type 2 Diabetes. Can J Diabetes. 2018;42(6):588-594.  https://doi.org/10.1016/j.jcjd.2018.02.012
  65. Neyestani TR, Nikooyeh B, Alavi-Majd H, Shariatzadeh N, Kalayi A, Tayebinejad N, Heravifard S, Salekzamani S, Zahedirad M. Improvement of vitamin D status via Daily intake of fortified yogurt Drink either with or without extra calcium ameliorates systemic inflammatory biomarkers, including adipokines, in the subjects with type 2 diabetes. J Clin Endocrinol Metab. 2012;97(6):2005-2011. https://doi.org/10.1210/jc.2011-3465
  66. Neyestani TR, Djazayery A, Shab-Bidar S, Eshraghian MR, Kalayi A, Shariátzadeh N, Khalaji N, Zahedirad M, Gharavi A, Houshiarrad A, Chamari M, Asadzadeh S. Vitamin D Receptor Fok-I polymorphism modulates Diabetic host response to vitamin D intake: need for a nutrigenetic approach. Diabetes Care. 2013;36(3):550-556.  https://doi.org/10.2337/dc12-0919
  67. Von Hurst PR, Stonehouse W, Coad J. Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D Deficient — A randomised, placebo-controlled trial. Br J Nutr. 2010;103:549-555.  https://doi.org/10.1017/S0007114509992017
  68. Grimnes G, Figenschau Y, Almas B, Jorde R. Vitamin D insulin secretion, sensitivity, and lipids: Results from a case-control study and a randomized controlled trial using hyperglycemic clamp technique. Diabetes. 2011;60:2748-2757. https://doi.org/10.2337/db11-0650
  69. Gepner AD, Ramamurthy R, Krueger DC, Korcarz CE, Binkley N, Stein JH. A prospective randomized controlled trial of the effects of vitamin D supplementation on cardiovascular Disease risk. PLoS ONE. 2012;7:e36617. https://doi.org/10.1371/journal.pone.0036617
  70. Jorde R, Sollid ST, Svartberg J, Schirmer H, Joakimsen RM, Njolstad I, Fuskevag OM, Figenschau Y, Hutchinson MY. Vitamin D 20,000 IU per Week for Five Years Does Not Prevent Progression from Prediabetes to Diabetes. J Clin Endocrinol Metab. 2016;101:1647-1655. https://doi.org/10.1210/jc.2015-4013
  71. Pittas AG, Dawson-Hughes B, Sheehan P, Ware JH, Knowler WC, Aroda VR, Brodsky I, Ceglia L, Chadha C, Chatterjee R, et al. Vitamin D Supplementation and Prevention of Type 2 Diabetes. N Engl J Med. 2019. https://doi.org/10.1056/NEJMoa1900906
  72. Hirschler V, Maccallini G, Sanchez M, Claudio G, Molinari C, Figueroa M, Arnada C, Hidalgo M. Improvement of Apolipoprotein B in Argentine Indigenous School Children after Vitamin D Supplementation. Cardiovasc Hematol Agents Med Chem. 2015;13:137-145.  https://doi.org/10.2174/1871525712666140516102319
  73. Kelishadi R, Salek S, Salek M, Hashemipour M, Movahedian M. Effects of vitamin D supplementation on insulin resistance and cardiometabolic risk factors in children with metabolic syndrome: A triple-masked controlled trial. J Pediatr. 2014;90:28-34.  https://doi.org/10.1016/j.jped.2013.06.006
  74. Nader NS, Aguirre Castaneda R, Wallace J, Singh R, Weaver A, Kumar S. Effect of vitamin D3 supplementation on serum 25(OH)D, lipids and markers of insulin resistance in obese adolescents: A prospective, randomized, placebo-controlled pilot trial. Horm Res Paediatr. 2014;82:107-112.  https://doi.org/10.1159/000362449
  75. Ferira AJ, Laing EM, Hausman DB, Hall DB, McCabe GP, Martin BR, Hill Gallant KM, Warden SJ, Weaver CM, Peacock M, et al. Vitamin D Supplementation Does Not Impact Insulin Resistance in Black and White Children. J Clin Endocrinol Metab. 2016;101:1710-1718. https://doi.org/10.1210/jc.2015-3687
  76. Kim D. The Role of Vitamin D in Thyroid Diseases. Int J Mol Sci. 2017;18(9):1949. Published 2017 Sep 12.  https://doi.org/10.3390/ijms18091949
  77. Chen W, Lin H, Wang M. Immune intervention effects on the induction of experimental autoimmune thyroiditis. Huazhong Univ Sci Technol Med Sci. 2002;22:343-345.  https://doi.org/10.1007/BF02896782
  78. Liu S, Xiong F, Liu EM, Zhu M, Lei PY. Effects of 1,25-dihydroxyvitamin D3 in rats with experimental autoimmune thyroiditis. J South Med Univ. 2010;30:1573-1576.
  79. Kivity S, Agmon-Levin N, Zisappl M, Shapira Y, Nagy EV, Dankó K, Szekanecz Z, Langevitz P, Shoenfeld Y. Vitamin D and autoimmune thyroid Diseases. Cell Mol Immunol. 2011;8:243-247.  https://doi.org/10.1038/cmi.2010.73
  80. Metwalley KA, Farghaly HS, Sherief T, Hussein A. Vitamin D status in children and adolescents with autoimmune thyroiditis. J Endocrinol Investig. 2016;39:793-797.  https://doi.org/10.1007/s40618-016-0432-x
  81. Mazokopakis EE, Papadomanolaki MG, Tsekouras KC, Evangelopoulos AD, Kotsiris DA, Tzortzinis AA. Is vitamin D related to pathogenesis and treatment of Hashimoto’s thyroiditis? Hell J Nucl Med. 2015;18:222-227. 
  82. Yasuda T, Okamoto Y, Hamada N, Miyashita K, Takahara M, Sakamoto F, Miyatsuka T, Kitamura T, Katakami N, Kawamori D, et al. Serum vitamin D levels are Decreased and associated with thyroid volume in female patients with newly onset Graves’ Disease. Endocrine. 2012;42:739-741.  https://doi.org/10.1007/s12020-012-9679-y
  83. Zhang H, Liang L, Xie Z. Low vitamin D status is associated with increased thyrotropin-receptor antibody titer in Graves’ Disease. Endocr Pract. 2015;21:258-263.  https://doi.org/10.4158/EP14191.OR
  84. Kurylowicz A, Ramos-Lopez E, Bednarczuk T, Badenhoop K. Vitamin D-binding protein (DBP) gene polymorphism is associated with Graves’ Disease and the vitamin D status in a Polish population study. Exp Clin Endocrinol Diabetes. 2006;114:329-335.  https://doi.org/10.1055/s-2006-924256
  85. Kurahashi I, et al. Dexamethasone Enhances Vitamin D-24-Hydroxylase Expression in Osteoblastic (UMR-106) and Renal (LLC-PK 1) Cells Treated with 1a, 25-Dihydroxyvitamin D3. Endocrine. 2002;2(17):109-118. 
  86. Khomenko AV. Cholecalciferol hydroxylation in rat hepatocytes under the influence of prednisolone. Ukr Biokhim Zh. 2013;3(85):90-95. 
  87. Dhawan P, Christakos S. Novel Regulation of 25-Hydroxyvitamin D3 24-Hydroxylase (24(OH)ase) Transcription by Glucocorticoids: Cooperative Effects of the Glucocorticoid Receptor, C/EBPb, and the Vitamin D Receptor in 24(OH)ase Transcription. Journal of Cellular Biochemistry. 2010;6(110):1314-1323.
  88. Ringe JD, et al. Superiority of alfacalcidol over plain vitamin D in the treatment of glucocorticoid-induced osteoporosis. Rheumatol Int. 2004;24:63-70. 
  89. Shymanskyi I, et al. Vitamin D3 Modulates impaired crosstalk between RANK and glucocorticoid receptor signaling in bone marrow cells after chronic prednisolone administration. Frontiers in Endocrinology. 2018;9:303. 

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