Laboratory support for assessing the hemostatic system in a physiologically proceeding pregnancy, in risk groups for the development of thrombosis and gestational complications: expert opinion

Vavilova T.V.

Federal State Budgetary Institution «V.A. Almazov Federal North-West Medical Research Centre», St. Petersburg, Russia

SPIN RSCI: 9003-6455
Scopus AuthorID: 7004477312
ORCID: 0000-0001-8537-3639

Momot A.P.

Altai Branch of the FSBI «National Research Center for Hematology», Barnaul, Russia

Papayan L.P.

Coagulation laboratory, Russian Scientific Research Institute of Hematology and Transfusiology, Russia

Zazerskaia I.E.

Federal'nyĭ tsentr serdtsa, krovi i éndokrinologii im. V.A. Almazova

Zajnulina M.S.

Snegirev Maternity Hospital No 6, Saint Petersburg;
Pavlov First Saint Petersburg State Medical University

Mamaev A.N.

GBOU VPO «Altajskij gosudarstvennyj meditsinskij universitet» Minzdrava Rossii, Barnaul

Nikolaeva M.G.

Obstetrics and Gynecology Department with the course of Supplementary Vocational Education in FSBEI of Higher Education «Altai State Medical University» Barnaul, Russia

Romanov V.V.

Invitro-Sibir LTD, Novosibirsk, Russian Federation

Korzo T.M.

Mother And Child clinic, St-Petersburg,Russia

Bobrov S.A.

Department of obstetrics and pathological pregnancies, Research Institute of Obstetrics and Gynecology named after D.O. Ott

Kornyushina E.A.

Department of obstetrics and pathological pregnancies, Research Institute of Obstetrics and Gynecology named after D.O. Ott

Laboratory support for assessing the hemostatic system in a physiologically proceeding pregnancy, in risk groups for the development of thrombosis and gestational complications: expert opinion

Authors:

Vavilova T.V., Momot A.P., Papayan L.P., Zazerskaia I.E., Zajnulina M.S., Mamaev A.N., Nikolaeva M.G., Romanov V.V., Korzo T.M., Bobrov S.A., Kornyushina E.A.

More about the authors

Journal: Laboratory Service. 2019;8(3): 55‑64

DOI: 10.17116/labs2019803155

Downloaded: 38

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Vavilova TV, Momot AP, Papayan LP, et al. . Laboratory support for assessing the hemostatic system in a physiologically proceeding pregnancy, in risk groups for the development of thrombosis and gestational complications: expert opinion. Laboratory Service. 2019;8(3):55‑64. (In Russ.)
https://doi.org/10.17116/labs2019803155

Close metadata

Recommended articles:

Factors of the hemostasis system as biomarkers of severe course of acute viral infections. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(3):63-74

Justification of systemic antibacterial therapy in patients with subclinical intrauterine infection during pregnancy. Russian Bulletin of Obstetrician-Gynecologist. 2024;(2):62-67

Adverse perinatal outcomes in COVID-19. Analysis of a series of clinical observations. Russian Bulletin of Obstetrician-Gynecologist. 2024;(2):86-90

The problem of venous thromboembolic complications prevention in the realities of modern obstetrics. Russian Bulletin of Obstetrician-Gynecologist. 2024;(2):104-111

Platelet apoptosis markers under anticoagulation for COVID-19 infection. Russian Journal of Cardiology and Cardiovascular Surgery. 2024;(2):194-203

Hemorrhagic stroke during pregnancy as a result of rupture of cavernous malformation. Clinical case. Russian Journal of Human Reproduction. 2024;(2):90-95

Efficacy and Safety of Different Anticoagulation Regimens for Deep Vein Thrombosis in Real Clinical Practice. Journal of Venous Disorders. 2024;(2):89-99

Peculiarities of local mRNA gene expression of pro- and anti-inflammatory cytokines in term pregnancy. Russian Bulletin of Obstetrician-Gynecologist. 2024;(3):6-13

The problem of diabetes mellitus in obstetrics. Russian Bulletin of Obstetrician-Gynecologist. 2024;(3):25-29

Abstract Many pregnancy complications are associated with abnormalities in the hemostatic system: venous thromboembolic complications (VTE) and/or arterial thrombosis and placenta associated complications (fetal loss syndrome, pre-eclampsia, delayed growth of the fetus, premature detachment of the placenta). The limitation of remodeling and thrombus formation in the myometrial segments of the spiral arteries is considered as one of the links in the pathogenesis of the latter. The agreed consensus of experts on laboratory support of a physiologically proceeding pregnancy is presented, which should provide objective information by an obstetrician-gynecologist, but not be overly burdensome for the pregnant woman and the health care system as a whole. Labeled laboratory studies, informative in the presence of risk factors for placenta-associated complications. Considered options for laboratory studies on the basis of reference values and pathogenetic mechanisms of complications.

Keywords:

pregnancy

venous thromboembolic complications

obstetric complications

physiological pregnancy

hemostasis system

fibrinolysis system

reference values

risk of thromboembolic and gestational complications

Authors:

Vavilova T.V.

Federal State Budgetary Institution «V.A. Almazov Federal North-West Medical Research Centre», St. Petersburg, Russia

SPIN RSCI: 9003-6455
Scopus AuthorID: 7004477312
ORCID: 0000-0001-8537-3639

Momot A.P.

Altai Branch of the FSBI «National Research Center for Hematology», Barnaul, Russia

Papayan L.P.

Coagulation laboratory, Russian Scientific Research Institute of Hematology and Transfusiology, Russia

Zazerskaia I.E.

Federal'nyĭ tsentr serdtsa, krovi i éndokrinologii im. V.A. Almazova

Zajnulina M.S.

Snegirev Maternity Hospital No 6, Saint Petersburg;
Pavlov First Saint Petersburg State Medical University

Mamaev A.N.

GBOU VPO «Altajskij gosudarstvennyj meditsinskij universitet» Minzdrava Rossii, Barnaul

Nikolaeva M.G.

Obstetrics and Gynecology Department with the course of Supplementary Vocational Education in FSBEI of Higher Education «Altai State Medical University» Barnaul, Russia

Romanov V.V.

Invitro-Sibir LTD, Novosibirsk, Russian Federation

Korzo T.M.

Mother And Child clinic, St-Petersburg,Russia

Bobrov S.A.

Department of obstetrics and pathological pregnancies, Research Institute of Obstetrics and Gynecology named after D.O. Ott

Kornyushina E.A.

Department of obstetrics and pathological pregnancies, Research Institute of Obstetrics and Gynecology named after D.O. Ott

List of references:

Royal College of Obstetricians and Gynaecologists. Reducing the Risk ofVenous Thromboembolism during Pregnancy and the Puerperium. Green-top Guideline No. 37a. London: RCOG; 2015. https://www.rcog.org.uk/globalassets/documents/guidelines/gtg-37a.pdf
Miyakis S, Lockshin M, Atsumi T, et al. International consensus statement on an update of the classifi cation criteria for defi nite antiphospholipid syndrome (APS). J Thromb Haemost. 2006;4:295-306.
Zobova DA, Kozlov SA. The role of homocysteine in the pathogenesis of certain diseases. News of higher educational institutions. Volga region. Medical sciences. 2016; 3 (39): 132-144. https://doi.org/10.21685/2072-3032-2016-3-15
Sidel’nikova VM, Shmakov RG. Mekhanizmy adaptatsii i dizadaptatsii gemostaza pri beremennosti. M.: Triada-Kh; 2004. (In Russ.)
Hale SA, Sobel B, Benvenuto A, Schonberg A, Badger GJ, Bernstein IM. Coagulation and Fibrinolytic System Protein Profiles in Women with Normal Pregnancies and Pregnancies Complicated by Hypertension. Pregnancy Hypertens. 2012;2(2):152-157. https://doi.org/10.1016/j.preghy.2012.01.004
Drury-Stewart DN, Lannert KW, Chung DW, Teramura GT, Zimring JC, Konkle BA, Gammill HS, Johnsen JM. Complex Changes in von Willebrand Factor-Associated Parameters Are Acquired during Uncomplicated Pregnancy. PLoS ONE. 2014;9(11):e112935. https://doi.org/10.1371/journal.pone.0112935
Heit J. Thrombophilia: Clinical and Laboratory Assessment and Management. In: Kithens C.S., Kessler C.M., Konkle B.A., eds. Consultative Hemostasis and Thrombosis. 3rd ed. Philadelphia: Saunders Elsevier; 2013.
Letter of the Ministry of Health of Russia dated May 27, 2014 No. 15-4 / 10 / 2-3792 — O prevention of venous thromboembolic complications in obstetrics and gynecology. Clinical recommendations (treatment protocol). M. 2014; 33. http://phlebology-sro.ru/upload/iblock / 429 / 5_profi laktika-venoznykh-tromboembolicheskikhoslozhneniy-v-akusherstve-i-ginekologii.pdf
Di Renzo GC. The great obstetrical syndromes. J Matern Fetal Neonatal Med. 2009;22(8):633-635. https://doi.org/10.1080/14767050902866804
Momot AP, Molchanova IV, Batrak TA, Belozerov DE, Trukhina DA, Kudinova IYu, Maksimova NV, Fadeeva NI, Serdyuk GV, Romanov VV. Reference values of hemostatic system parameters in normal pregnancy and after delivery. Problemy reproduktsii. 2015;1(21):89-97. (In Russ.) https://doi.org/10.17116/repro20152189-977.
Momot AP, Semenova NA, Belozerov DE, Trukhina DA, Kudinova IYu. The Dynamics of the hemostatic Parameters in Physiological Pregnancy and After Delivery. J Hematol Blood Transfus Disord. 2016;3:005. https://doi.org/10.18411/d-2016-058
Federal'nyi zakon ot 25.12.18 №489-FZ «O vnesenii izmenenii v stat'yu 40 Federal'nogo zakona «Ob obyazatel'nom meditsinskom strakhovanii» i Federal'nyi zakon «Ob osnovakh zdorov'ya grazhdan v Rossiiskoi Federatsii» po voprosam klinicheskikh rekomendatsii».
Prikaz Minzdrava Rossii ot 01.11.12 №572n — Ob utverzhdenii Poryadka okazaniya meditsinskoi pomoshchi po profilyu «Akusherstvo i ginekologiya (za isklyucheniem ispol'zovaniya vspomogatel'nykh reproduktivnykh tekhnologii)». M. 2012;368. http://disuria.ru/_ld/1/167_Pr572nMZ011112.pdf
Abbassi-Ghanavati M, Greer LG, Cunningham FG. Pregnancy and laboratory studies: a reference table for clinicians. Obstet Gynecol. 2009;114(6):1326-1331. PMID:19935037.
Wickstrӧm K, Edelstam G, Lӧwbeer CH, Hansson LO, Siegbahn A. Reference intervals for plasma levels of ﬁbronectin, von Willebrand factor, free protein S and antithrombin during third-trimester pregnancy. Scand J Clin Lab Invest. 2004;64(1):31-40.
Sánchez-Luceros A, Farías CE, Amaral MM, Kempfer AC, Votta R, Marchese C, Salviú MJ, Woods AI, Meschengieser SS, Lazzari MA. von Willebrand factor-cleaving protease (ADAMTS13) activity in normal non-pregnant women, pregnant and post-delivery women. Thromb Haemost. 2004;92(6):1320-1326.
Cunningham FG. Laboratory Values in Normal Pregnancy. Appendix B. In: John T. Queenan, John C. Hobbins, Catherine Y. Spong, eds. Protocols for High-Risk Pregnancies: An Evidence-Based Approach. Fifth Ed. Oxford, UK: Blackwell Science Ltd; 2010. https://doi.org/10.1002/9781444323870.app2
Gong JM, Shen Y, He YX. Reference Intervals of Routine Coagulation Assays During the Pregnancy and Puerperium Period. J Clin Lab Anal. 2016;30(6):912-917. https://doi.org/10.1002/jcla.21956
Cui C, Yang S, Zhang J, Wang G, Huang S, Li A, Zhang Y, Qiao R. Trimester-specific coagulation and anticoagulation reference intervals for healthy pregnancy. Thromb Res. 2017;156:82-86. https://doi.org/10.1016/j.thromres.2017.05.021
Sharief LT, Lawrie AS, Mackie IJ, Smith C, Peyvandi E, Kadir RA. Changes in factor XIII level during pregnancy. Haemophilia. 2014;20:144-148.
Momot AP, Molchanova IV, Semenova NA, Romanov VV, Serdyuk GV, Belozerov DE, Trukhina DA, Kudinova IYu, Maksimova NV. Dynamics of hevostatic parameters on pregnant women and after delivery. Laboratornaya sluzhba. 2015;2(4):3-11. (In Russ.) https://doi.org/10.17116/labs2015423-11
Hedengran KK, Andersen MR, Stender S, Szecsi PB. Large D-Dimer Fluctuation in Normal Pregnancy: A Longitudinal Cohort Study of 4,117 Samples from 714 Healthy Danish Women. Obstet Gynecol Int. 2016;2016:3561675. https://doi.org/10.1155/2016/3561675
Giavarina D, Mezzena G, Dorizzi RM, Soffiati G. Reference interval of D-dimer in pregnant women. Clin Biochem. 2001;34(4):331-333.
Bellart J, Gilabert R, Fontcuberta J, Borrell M, Miralles RM, Cabero L. Fibrinolysis changes in normal pregnancy. J Perinat Med. 1997;25(4):368-372.
Gribkova IV, Koroleva NS, Davydovskaya MV, Murash- to AV. Increased thrombin formation is a potential marker of adverse pregnancy outcomes. Obstetrics and gynecology. 2018;8:92-97. https://doi.org/10.18565/aig.2018.8.92-97
McLean KC, Bernstein IM, Brummel-Ziedins K. Tissue factor dependent thrombin generation across pregnancy. Am J Obstet Gynecol. 2012;207(2):135e1-135e6.
Grinevich TN. Values of indicators of rotational thromboelastometry in various periods of a physiologically occurring pregnancy. Laboratory diagnostics. Eastern Europe. 2016;3:327-336.
Huissoud C, Carrabin N, Benchaib M, Fontaine O, Levrat A, Massignon D, Touzet S, Rudigoz RC, Berland M. Coagulation assessment by rotation thrombelastometry in normal pregnancy. Thromb Haemost. 2009;101(4):755-761.
Voroshilina ES, Hovsepyan RA, Plotko EE. and others. The ranges of normal values for the parameters of standard coagulological tests and thrombodynamics test during physiological pregnancy at different gestational periods. Bulletin of the Russian State Medical University. 2015;4:40-45.
Ataullakhanov FI, Koltsova EM, Balandina AN, Serebriyskiy II, Vuimo TA, Panteleev MA. Classic and Global Hemostasis Testing in Pregnancy and during Pregnancy Complications. Semin Thromb Hemost. 2016;42(7):696-716. https://doi.org/10.1055/s-0036-1592303
Ubeda N, Reyes L, González-Medina A, Alonso-Aperte E, Varela-Moreiras G. Physiologic changes in homocysteine metabolism in pregnancy: a longitudinal study in Spain. Nutrition. 2011;27(9):925-930. https://doi.org/10.1016/j.nut.2010.10.017
Bokeriya LA, Zatevakhin II, Kirienko AI, Andriyashkin AV, Andriyashkin VV, Arutyunov GP, Barinov VE, Bitsadze VO, Bodykhov MK, Britov AN, Butenko AV, Vavilova TV, Vorob’eva NA, Voskanyan YuE, Gavrilenko AV, Galstyan GM, Gel’fand BR, Gilyarov MYu, Golubev GSh, Zamyatin MN, Zolotukhin IA, Kobalava ZhD, Katel’nitskii II, Kopenkin SS, Kuznetsov MR, Leont’ev SG, Lobastov KV, Lubnin AYu, Makatsariya AD, Moiseev VS, Momot AP, Ostryakova EV, Panchenko EP, Perekhodov SN, Piradov MA, Poddubnaya IV, Pokrovskii AV, Protsenko DN, Prudkov MI, Pryadko SI, Pyregov AV, Reshetnyak TM, Ryabinkina YuV, Sapelkin SV, Semenova MN, Smirnov SV, Sokolov VA, Stakhovskaya LV, Stoiko YuM, Sulimov VA, Sukhikh GT, Tereshchenko SN, Fokin AA, Khruslov MV, Shevela AI, Shimanko AI, Shulutko AM, Yavelov IS, Yakhontov DI. Rossiiskie klinicheskie rekomendatsii po diagnostike, lecheniyu i profilaktike venoznykh tromboembolicheskikh oslozhnenii. Flebologiya. 2015;9(4-2):2-52. (In Russ.)
Stevens SM, Woller SC, Bauer KA, Kasthuri R, Cushman M, Streiff M, Lim W, Douketis JD. Guidance for the evaluation and treatment of hereditary and acquired thrombophilia. J Thromb Thrombolysis. 2016;41:154-164.
Milovanov AP, Kiryushchenkov PA, Shmakov RG, Orazmuradov AA, Khubetseva MT. Platsenta — regulyator gemostaza materi. Akusherstvo i ginekologiya. 2001;3:3-6. (In Russ)
James JL, Stone PR, Chamley LW. The regulation of trophoblast differentiation by oxygen in the first trimester of pregnancy. Hum Reprod Update. 2006;12(2):137-144. https://doi.org/10.1093/humupd/dmi043
Rodger MA, Betancourt MT, Clark P, et al. The association of factor V leiden and prothrombin gene mutation and placenta-mediated pregnancy complications: a systematic review and meta-analysis of prospective cohort studies. PLoS Med. 2010;7:e10002927.
Hansen AT, Schmidt M, Horvath-Puho E, Pedersen L, Rothman KJ, Hvas AM, Sørensen HT. Preconception venous thromboembolism and placenta-mediated pregnancy complications. J Thromb Haemost. 2015;13:1635-1641.
Miyakis S, Lockshin M, Atsumi T, et al. International consensus statement on an update of the classifi cation criteria for defi nite antiphospholipid syndrome (APS). J Thromb Haemost. 2006;4:295-306.
Moore Recent Guidelines and Recommendations for Laboratory Detection of Lupus Anticoagulants. Semin Thromb Hemost. 2014;40:163-171.
Giannakopoulos B, Passam F, Ioannou Y, Krilis SA. How we diagnose the antiphospholipid syndrome. Blood. 2009;113:985.
Bertolaccini ML, Gomez S, Pareja JF, et al. Antiphospholipid antibody tests: spreading the net. Ann Rheum Dis. 2005;64:1639.
Bates SM, Greer IA, Middeldorp S, et al. VTE, thrombophilia, antithrombotic therapy, and pregnancy: Antithrombotic Therapy and Prevention of Thrombosis, 9 th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141:e691.

Close metadata