Deep muscle pain threshold as a possible criterion for assessment of small fiber neuropathy

Karnishkina O.Yu.; Bukhantseva D.S.; Didur E.A.; Lytochkina S.V.; Deffo A.E.D.; Karelov A.E.; Babenko A.Yu.; Dobretsov M.G.

doi:https://doi.org/10.17116/anaesthesiology202501176

Karnishkina O.Yu.

Sechenov Institute of Evolutionary Physiology and Biochemistry

ORCID: 0000-0002-2242-4141

Bukhantseva D.S.

Almazov National Medical Research Centre;
Southern District Medical Center of the Federal Medical Biological Agency

Didur E.A.

Almazov National Medical Research Centre

ORCID: 0009-0001-6083-8150

Lytochkina S.V.

Mechnikov North-Western State Medical University

ORCID: 0009-0007-8127-7800

Deffo A.E.D.

Mechnikov North-Western State Medical University

ORCID: 0009-0004-6751-9525

Karelov A.E.

Mechnikov North-Western State Medical University

Scopus AuthorID: 6508037675
ORCID: 0000-0003-4401-1599

Babenko A.Yu.

Almazov National Medical Research Centre

ORCID: 0000-0002-0559-697X

Dobretsov M.G.

Sechenov Institute of Evolutionary Physiology and Biochemistry

ORCID: 0000-0001-6007-9775

Deep muscle pain threshold as a possible criterion for assessment of small fiber neuropathy

Authors:

Karnishkina O.Yu., Bukhantseva D.S., Didur E.A., Lytochkina S.V., Deffo A.E.D., Karelov A.E., Babenko A.Yu., Dobretsov M.G.

More about the authors

Journal: Russian Journal of Anesthesiology and Reanimatology. 2025;(1): 76‑80

DOI: 10.17116/anaesthesiology202501176

Read: 733 times

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To cite this article:

Karnishkina OYu, Bukhantseva DS, Didur EA, et al. . Deep muscle pain threshold as a possible criterion for assessment of small fiber neuropathy. Russian Journal of Anesthesiology and Reanimatology. 2025;(1):76‑80. (In Russ.)
https://doi.org/10.17116/anaesthesiology202501176

Использование инфографики авторами научных работ

Abstract:

Currently, diagnostic methods for early stages of small fiber neuropathy are limited.

OBJECTIVE

To determine reference values for assessing distal (dorsum of the foot) deep muscle pain pressure thresholds in apparently healthy individuals.

MATERIAL AND METHODS

Sixty-five apparently healthy individuals aged 18—60 years (42 women and 23 men) were studied. PPT was measured using manual mechanical algometer FDK5 (Wagner Instruments, USA) with semicircular smooth applicator. The testing site was dorsum of the foot approximately 0.5—1 cm below the arcuate artery between metatarsal bones of the 3^rd and 4^th toes.

RESULTS

Age of men and women was similar (28.4±2.2 and 26.4±1.6 years, respectively). Men were taller and had higher weight and body mass index (BMI). However, PPT of the right and left feet did not differ from each other and did not depend on BMI. Mean PPT was similar in men and women. In the entire sample (men and women), distribution of PPT was satisfactorily (R²=0.742) described by normal Gaussian curve with a peak at 1.76 kg/cm² and standard deviation 0.49 kg/cm².

CONCLUSIONS

The proposed method allows us to determine deep muscle pain thresholds of the dorsum of the foot with minimal activation of nociceptors of large blood vessels, periosteum or tendons. The method can be used for early diagnosis of muscle hyperalgesia as one of the signs of small fiber neuropathy.

Keywords:

small fiber neuropathy

algometer

deep muscle pain

pain detection threshold

reference values

screening method

Authors:

Karnishkina O.Yu.

Sechenov Institute of Evolutionary Physiology and Biochemistry

ORCID: 0000-0002-2242-4141

Bukhantseva D.S.

Almazov National Medical Research Centre;
Southern District Medical Center of the Federal Medical Biological Agency

Didur E.A.

Almazov National Medical Research Centre

ORCID: 0009-0001-6083-8150

Lytochkina S.V.

Mechnikov North-Western State Medical University

ORCID: 0009-0007-8127-7800

Deffo A.E.D.

Mechnikov North-Western State Medical University

ORCID: 0009-0004-6751-9525

Karelov A.E.

Mechnikov North-Western State Medical University

Scopus AuthorID: 6508037675
ORCID: 0000-0003-4401-1599

Babenko A.Yu.

Almazov National Medical Research Centre

ORCID: 0000-0002-0559-697X

Dobretsov M.G.

Sechenov Institute of Evolutionary Physiology and Biochemistry

ORCID: 0000-0001-6007-9775

Received:

04.07.2024

Accepted:

26.08.2024

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