Non-melanoma skin cancer is one of the most common comorbid pathologies of transplants recipients. Moreover, the number of organs transplantations in the treatment of patients with terminal organs failure is increasing: there was 2555 organs transplantations in 2022 yr. in the RF according to the data of Federal register. The number of organs transplants in the RF increased by 10% compared to 2021 yr. The article presents the data of foreign and Russian authors with reports on occurring non-melanoma skin cancers after parenchymatous organs transplantation, as well as on successful use of photodynamic therapy (PDT) in transplant recipients. Two clinical observations of transplant recipients with malignant non-melanoma skin cancers are presented. In the first clinical observation a 68-years-old patient with CT2(m=16)N0M0 squamous cell skin cancer (multifocal form) after liver transplantation performed in 2016 yr. was described. The patient was undergone PDT with good clinical effect in 2021 yr. There have been no signs of disease relapse in areas of PDT within further 24 months of observation. The second clinical observation describes a 73-years-old female patient who underwent a kidney transplantation in 2003 yr. due to chronic renal failure. She was diagnosed with basal cell skin cancer of the forehead (cT2N0M0) for which PDT was performed. As a result of treatment there have been no relapses of the disease in the PTD area within 18 months of observation.