A clinical case of the Meyerson’s phenomenon in two 23-year-old patients with identical localization on the hip and similar clinical picture and history (complaints of itching and inflammation in the area of moles on the right hip, onset of atypical melanocytic formation in the center with an eczematous halo about 1 month ago without apparent reason) is described. The data of histological examination are presented, the conducted therapy and its results are described. The treatment included the use of cream with corticosteroids followed by an excisional biopsy. Dysplastic nevus with low-grade dysplasia of melanocytes and high-grade dysplastic nevus, melanocytic nevus without perivascular and perineural invasions have been revealed in histological examination. The feature of these clinical cases was the match of patients by gender, age and localization of nevuses. The inflammatory events of the Meyerson’s phenomenon can be resolved spontaneously or in the course of the treatment with topical steroids. The Meyerson’s phenomenon is more common in young men and tends to occur in summer. Meyerson’s nevus is usually a single find, but multiple foci can simultaneously appear. The main problem of benign lesions proceeding with inflammation is malignant transformation.