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Roytman A.P.

Russian Medical Academy for Continuous Professional Education

Kuznetsova T.E.

Russian Medical Academy for Continuous Professional Education;
Sklifosovsky Research Institute for Emergency Medicine

Belyaev I.A.

Mandryk Central Military Clinical Hospital

Bugrov A.V.

Russian Medical Academy for Continuous Professional Education

Tazina S.Ya.

Sechenov First Moscow State Medical University

Dolgov V.V.

Russian Medical Academy for Continuous Professional Education

Godkov M.A.

Russian Medical Academy for Continuous Professional Education;
Sklifosovsky Research Institute for Emergency Medicine

Laboratory biomarkers for the prognosis of chronic heart failure

Authors:

Roytman A.P., Kuznetsova T.E., Belyaev I.A., Bugrov A.V., Tazina S.Ya., Dolgov V.V., Godkov M.A.

More about the authors

Journal: Laboratory Service. 2024;13(3): 5‑16

DOI: 10.17116/labs2024130315

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Table of contents

LABORATORY BIOMARKERS FOR THE PROGNOSIS OF CHRONIC HEART FAILURE
LABORATORY BIOMARKERS FOR THE PROGNOSIS OF CHRONIC HEART FAILURE

To cite this article:

Roytman AP, Kuznetsova TE, Belyaev IA, Bugrov AV, Tazina SYa, Dolgov VV, Godkov MA. Laboratory biomarkers for the prognosis of chronic heart failure. Laboratory Service. 2024;13(3):5‑16. (In Russ.)
https://doi.org/10.17116/labs2024130315

 
Подписка 2025-2 (Laboratory Service)
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INTRODUCTION

Chronic heart failure (CHF) is a pressing worldwide medical problem, in our country in particular. The incidence of CHF is constantly increasing. The epidemiological forecast shows that by 2050, the number of patients with CHF will increase by 60% compared to 2010. According to the latest data, the total number of patients with CHF in Russia is 12 million, 4.5 million of whom have III and IV New York Heart Association (NYHA) functional class. Heart transplantation is a high-tech method of treating terminal heart failure and is recognized as the gold standard of care for patients whose risk of death within a year is more than 50% if it is impossible to use other methods of treatment. A number of new laboratory biomarkers can help predict adverse outcomes in patients with CHF.

OBJECTIVE

To summarize information about laboratory biomarkers for the assessment and prognosis of CHF and explaine the actuality of their further study in clinical practice.

MATERIAL AND METHODS

This review is based on articles over the past 10 years conducted using the resources of the PubMed and eLIBRARY research engines using keywords.

RESULTS

Existing laboratory markers used to assess and predict the course of CHF have a number of limits. The comparison of biomarkers made including diagnostic characteristics, the advantages and disadvantages of using biomarkers in clinical practice.

CONCLUSION

It is efficient to use several laboratory biomarkers to assess and predict the course of CHF. The most promising laboratory biomarkers for the assessment and prognosis of CHF are neprilysin, fractalkine, interleukin-6 and biomarkers of of extracellular matrix metabolism (MMP-2, MMP-8, PIIINP and TIMP-1).

Keywords:

chronic heart failure
biomarkers
sensitivity
specificity

Authors:

Roytman A.P.

Russian Medical Academy for Continuous Professional Education

Kuznetsova T.E.

Russian Medical Academy for Continuous Professional Education;
Sklifosovsky Research Institute for Emergency Medicine

Belyaev I.A.

Mandryk Central Military Clinical Hospital

Bugrov A.V.

Russian Medical Academy for Continuous Professional Education

Tazina S.Ya.

Sechenov First Moscow State Medical University

Dolgov V.V.

Russian Medical Academy for Continuous Professional Education

Godkov M.A.

Russian Medical Academy for Continuous Professional Education;
Sklifosovsky Research Institute for Emergency Medicine

Received:

09.07.2024

Accepted:

08.10.2024

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