During pregnancy, a woman’s body undergoes many changes, including those that can cause dermatological conditions. Acne is a fairly common reason for visiting a dermatologist during pregnancy. Due to hormonal and immunological changes, the existing acne may worsen, or adolescent acne may relapse. Most cases of acne in pregnant women are mild to moderate. Rashes are more often localized on the mandibular region of the face, neck, and trunk. Acne therapy during pregnancy is challenging due to the impossibility of using some drugs in such patients and limited data on safe treatment methods. However, data on a topical combination of clindamycin and benzoyl peroxide for acne in pregnant women are available. Our experience demonstrates a significant improvement in acne after 3 weeks of use of this combination. It should be noted that when choosing acne therapy in women of childbearing age, prescribers must adapt the treatment considering the patient’s plans for reproduction.