3D optical coherence tomography for in vivo assessment of morphological state of skin and skin vessels in diabetes mellitus

Petrova K.S.

Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation

Nemirova S.V.

Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation

Petrova G.A.

Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation

Karpenko A.A.

Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation

ORCID: 0000-0001-6914-334X

Proydakova E.V.

Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation

Strongin L.G.

Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation

Shchukina D.A.

Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation

3D optical coherence tomography for in vivo assessment of morphological state of skin and skin vessels in diabetes mellitus

Authors:

Petrova K.S., Nemirova S.V., Petrova G.A., Karpenko A.A., Proydakova E.V., Strongin L.G., Shchukina D.A.

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Journal: Russian Journal of Clinical Dermatology and Venereology. 2022;21(5): 672‑680

DOI: 10.17116/klinderma202221051672

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To cite this article:

Petrova KS, Nemirova SV, Petrova GA, Karpenko AA, Proydakova EV, Strongin LG, Shchukina DA. 3D optical coherence tomography for in vivo assessment of morphological state of skin and skin vessels in diabetes mellitus. Russian Journal of Clinical Dermatology and Venereology. 2022;21(5):672‑680. (In Russ.)
https://doi.org/10.17116/klinderma202221051672

Подписка 2025-2 (Russian Journal of Clinical Dermatology and Venereology)

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OBJECTIVE

To study the feasibility of using 3D images acquired with optical coherence tomography (OCT) for in vivo examination of morphological skin features and skin vessel state in type II diabetes mellitus (DM) patients.

MATERIAL AND METHODS

We examined 100 patients (29 males and 71 females) with type II diabetes mellitus with clinical manifestations of trophic ulcers and diabetic foot, aged 45 to 84 years (mean age 61 years). The average duration of the DM was 15 years. The control group included 100 healthy volunteers (37 males and 63 females) aged 19 to 75 years (mean age of 33 years). We used an optical coherence tomography scanner for noninvasive examination of the internal structure of human superficial tissues OKT-1300-E (high-speed modification of 92.000 A-scans per 1 s) developed by BioMedTech LLC (Russia) (serial production at MelSyTech LLC). Images were obtained of the skin areas of the anterior surface of the middle third of the lower leg and the back of the foot of healthy volunteers. In patients with DM, areas of apparently healthy skin of the same localization were scanned.

RESULTS

OCT images of apparently healthy skin of DM patients showed OCT signs of malpighian layer thinning, which was a sign of atrophic processes in the epidermis. Edema in the foot area was observed. Virtually no hair follicles or glands were visualized. There was a decrease in the number and diameter of visualized microcirculatory vessels.

CONCLUSION

3D OCT scanning can be recommended for in vivo monitoring of the morphological state of the skin and skin vessels in DM.

Keywords:

diabetes mellitus

microangiopathy

optical coherence tomography

Authors:

Petrova K.S.

Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation

Nemirova S.V.

Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation

Petrova G.A.

Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation

Karpenko A.A.

Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation

ORCID: 0000-0001-6914-334X

Proydakova E.V.

Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation

Strongin L.G.

Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation

Shchukina D.A.

Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation

Received:

02.02.2021

Accepted:

28.07.2022

List of references:

Jaacks LM, Siegel KR, Gujral UP, Narayan KM. Type 2 diabetes: A 21st century epidemic. Best Pract Res Clin Endocrinol Metab. 2016 June;30(3): 331-343. https://doi.org/10.1016/j.beem.2016.05.003
Prescribing and Primary Care Team, Health and Social Care Information Centre. Quality and outcomes framework: achievement, prevalence and exceptions data, 2012/13. Vol. V1.0. 2013.
Yazdanpanah L, Nasiri M, Adarvishi S. Literature review on the management of diabetic foot ulcer. World J Diabetes. 2015;6:37-53. https://doi.org/10.4239/wjd.v6.i1.37
Kochet K, Lytus I, Svistunov I, Sulaieva O. Skin pathology in diabetes mellitus: clinical and pathophysiological correlations (review). Georgian Med News. 2017;273:41-46.
Quondamatteo F. Skin and diabetes mellitus: what do we know? Cell Tissue Res. 2014;355(1):1-21. https://doi.org/10.1007/s00441-013-1751-2
Fuchs D, Dupon PP, Schaap LA, Draijer R. The association between diabetes and dermal microvascular dysfunction non-invasively assessed by laser Doppler with local thermal hyperemia: A systematic review with meta-analysis. Cardiovasc Diabetol. 2017;16(1):11. https://doi.org/10.1186/s12933-016-0487-1
Murphy-Chutorian B, Han G, Cohen SR. Dermatologic manifestations of diabetes mellitus: A review. Endocrinol Metab Clin North Am. 2013;42(4):869-898. https://doi.org/10.1016/j.ecl.2013.07.004
Lima AL, Illing T, Schliemann S, Elsner P. Cutaneous Manifestations of Diabetes Mellitus: A Review. Am J Clin Dermatol. 2017;18(4):541-553. https://doi.org/10.1007/s40257-017-0275-z
Osawa S, Katakami N, Kuroda A, Takahara M, Sakamoto F, Kawamori D, Matsuoka T, Matsuhisa M, Shimomura I. Skin autofluorescence is Associated with early-stage atherosclerosis in patients with type 1 diabetes. J Atheroscler Thromb. 2017;24(3):312-326. https://doi.org/10.5551/jat.35592
Yoshioka K. Skin autofluorescence is a noninvasive surrogate marker for diabetic microvascular complications and carotid intima-media thickness in japanese patients with type 2 diabetes: A cross-sectional study. Diabetes Ther. 2018;9(1):75-85. https://doi.org/10.1007/s13300-017-0339-3
Ninomiya H, Katakami N, Sato I, Osawa S, Yamamoto Y, Takahara M, Kawamori D, Matsuoka TA, Shimomura I. Association between subclinical atherosclerosis markers and the level of accumulated advanced glycation end-products in the skin of patients with diabetes. J Atheroscler Thromb. 2018;25(12):1274-1284. https://doi.org/10.5551/jat.44859
Caballero AE, Arora S, Saouaf R, Lim SC, Smakowski P, Park JY, et al. Microvascular and macrovascular reactivity is reduced in subjects at risk for type 2 diabetes. Diabetes. 1999;48:1856-1862. https://doi.org/10.2337/diabetes.48.9.1856
Araszkiewicz A, Soska J, Borucka K, Olszewska M, Niedzwiecki P, Wierusz-Wysocka B, Zozulinska-Ziolkiewicz D. In diabetic Charcot neuroarthropathy impaired microvascular function is related to long lasting metabolic control and low grade inflammatory process. Microvascular Research. 2015;101: 143-147. https://doi.org/10.1016/j.mvr.2015.07.008
Mahe G, Humeau-Heurtier A, Durand S, Leftheriotis G, Abraham P. Assessment of skin microvascular function and dysfunction with laser speckle contrast imaging. Circ Cardiovasc Imaging. 2012;5:155-163. https://doi.org/10.1161/CIRCIMAGING.111.970418
Petrova GA, Petrova KS, Zorkina MV, Derpalyuk EN, Iksanov RR, Kamensky VA, Shlivko IL. Experimental identification of components of OCT images of healthy thin human skin. Rossiiskij zhurnal kozhnykh i venericheskikh boleznej. 2008;6:53-58. (In Russ.).
Petrova GA, Petrova KS, Nemirova SV. 3D-opticheskie kogerentnye tomogrammy kozhi v norme i pri dermatozakh. Atlas. Nizhny Novgorod; 2018. (In Russ.).
Petrova GA, Petrova KS, Nemirova SV, Karpenko AA. 3D optical coherence tomography is a new stage in the non-invasive study of skin morphology. Russian Journal of Clinical Dermatology and Venereology = Klinichaskaya dermatologiya i venerologiya. 2019;18(3):358-367. (In Russ.). https://doi.org/10.17116/klinderma201918031366
Chernukh AM et al. Kozha (Stroenie, funktsiya, obshch. patologiya i terapiya). M.: Meditsina; 1982:23. (In Russ.).
Petrova KS, Potekaev NN, Nemirova SV, Petrova GA, Karpenko AA. Three-dimensional optical coherence tomography: possibilities in assessing the microcirculatory bed of the skin. Russian Journal of Clinical Dermatology and Venereology = Klinichaskaya dermatologiya i venerologiya. 2020;19(3): 356-365. (In Russ.). https://doi.org/10.17116/klinderma202019031356
Tsvetkova GM, Mordovtseva VV, Vavilov AM, Mordovtsev VN. Patomorfologiya boleznej kozhi. M.: Meditsina; 2003:215. (In Russ.).
Petrova GA, Petrova KS, Nemirova SV, Potekaev NN, Ksenofontov SYu, Vasilenkova TV. 3D-opticheskaya kogerentnaya tomografiya kozhi: prizhiznennaya otsenka morfologicheskikh osobennostei zdorovoi kozhi i patomorfologicheskaya diagnostika dermatozov. Nizhny Novgorod: IP Yakushev Yu.I.; 2018:152. (In Russ.).

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