Current concepts of psoriatic arthritis pathogenesis

Khismatullina Z.R.; Koreshkova K.M.

doi:https://doi.org/10.17116/klinderma202221051583

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Abstract:

Psoriatic arthritis (PA) is a chronic immune inflammatory disease of the joints and entheses associated with psoriasis. Its pathogenesis involves various cellular-immune and genetic mechanisms. Currently, the mechanism of bone remodeling in PA has not been fully established, nor have any disease-specific laboratory markers been identified, making it difficult to establish the psoriatic nature of arthritis. Numerous studies on the role of abnormal signaling pathways, calcium metabolism, and matrix metalloproteinases in the development of PA are cited. A 2010-2021 literature review of the current concepts of PA pathogenesis is presented. The mechanisms of calcium metabolism disorder and bone tissue remodeling in PA patients were reviewed. The role of connective tissue destruction factors, such as matrix metalloproteinases, serum osteomalacia markers (alkaline phosphatase, acid α₁-glycoprotein, etc.), intercellular matrix destruction mechanisms, imbalanced expression of cellular components of bone homeostasis (osteoblasts, osteoclasts, etc.), was reviewed. The results of studies of serum parameters are presented. Their increase indicates the destruction of collagen and other connective tissue structures. Attempts to identify serum markers of systemic inflammation in PA are described. Their trends reflect the disease activity and therapy effectiveness.

Keywords:

psoriatic arthritis

matrix metalloproteinases

calcium

osteoprotegerin

RANKL

cathepsin G

alkaline phosphatase

acid α1-glycoprotein

Authors:

Khismatullina Z.R.

Bashkir State Medical University, Russia

ORCID: 0000-0001-8674-2803

Koreshkova K.M.

Bashkir State Medical University, Russia

ORCID: 0000-0001-6039-8311

Received:

12.10.2021

Accepted:

25.07.2022

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References:

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