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Ikonnikova E.V.

Central State Medical Academy of Administrative Directorate of the President of the Russian Federation;
Institute of Plastic Surgery and Cosmetology

Manturova N.E.

Pirogov Russian National Research Medical University;
Institute of Plastic Surgery and Cosmetology

Kruglova L.S.

Central State Medical Academy of Department of Presidential Affairs

Casuistic chain: COVID-19, inflammatory response to hyaluronic acid-based filler and xanthelasma

Authors:

Ikonnikova E.V., Manturova N.E., Kruglova L.S.

More about the authors

Journal: Russian Journal of Clinical Dermatology and Venereology. 2022;21(4): 555‑559

DOI: 10.17116/klinderma202221041555

Read: 2502 times

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Table of contents

CASUISTIC CHAIN: COVID-19, INFLAMMATORY RESPONSE TO HYALURONIC ACID-BASED FILLER AND XANTHELASMA
CASUISTIC CHAIN: COVID-19, INFLAMMATORY RESPONSE TO HYALURONIC ACID-BASED FILLER AND XANTHELASMA

To cite this article:

Ikonnikova EV, Manturova NE, Kruglova LS. Casuistic chain: COVID-19, inflammatory response to hyaluronic acid-based filler and xanthelasma. Russian Journal of Clinical Dermatology and Venereology. 2022;21(4):555‑559. (In Russ.)
https://doi.org/10.17116/klinderma202221041555

Подписка 2026 Клиническая дерматология и венерология (Russian Journal of Clinical Dermatology and Venereology)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The pandemic of a new coronavirus infection has posed many challenges and questions for medicine. Dermatologists, in particular, have encountered a wide variety of cutaneous manifestations of this infection. Apart from a fairly broad coverage of various rashes and features of the course of many chronic dermatoses, only sporadic descriptions of inflammatory reactions to cosmetic fillers are available. Objectives. An extremely rare complication is described: an inflammatory reaction to the injection of a hyaluronic acid-based filler, which, in turn, led to the occurrence of xanthelasma at the sites of filler localization during the recovery period after COVID-19.

MATERIAL AND METHODS

A patient presented with yellow lesions in the nasolacrimal sulcus area following the resolution of an inflammatory response to the injection of a hyaluronic acid-based filler during the recovery period after a COVID-19 infection.

RESULTS

The diagnosis was confirmed by ultrasound of the face skin and soft tissues, and the optimal therapy regimen was determined.

CONCLUSION

In the global medical practice, only single cases of xanthelasma and xanthelasma-like reactions after the filler injection are reported. In a scientific first, the pathogenetic chain including COVID-19, filler inflammatory response, and xanthelasma is described. The pathogenesis of this complication is also of particular interest and needs further study. Although extremely rare, physicians should be aware of this complication and its treatment options.

Keywords:

COVID-19
coronavirus infection
complications
xanthelasma
fillers
hyaluronic acid
nasolacrimal sulcus
laser
CO2 laser
fractional photothermolysis

Authors:

Ikonnikova E.V.

Central State Medical Academy of Administrative Directorate of the President of the Russian Federation;
Institute of Plastic Surgery and Cosmetology

Manturova N.E.

Pirogov Russian National Research Medical University;
Institute of Plastic Surgery and Cosmetology

Kruglova L.S.

Central State Medical Academy of Department of Presidential Affairs

Received:

12.09.2021

Accepted:

17.06.2022

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References:

  1. Beleznay K, Carruthers JDA, Carruthers A, et al. Delayed‐onset nodules secondary to a smooth cohesive 20 mg/mL hyaluronic acid filler: cause and management. Dermatol Surg. 2015;41(8):929‐939.  https://doi.org/10.1097/dss.0000000000000418
  2. Artzi O, Loizides C, Verner I, Landau M. Resistant and recurrent late reaction to hyaluronic acid‐based gel. Dermatol Surg. 2016;42(1):31‐37.  https://doi.org/10.1097/DSS.0000000000000562
  3. Funt D, Pavicic T. Dermal fillers in aesthetics: an overview of adverse events and treatment approaches. Clin Cosmet Investig Dermatol. 2013;6:295‐316.  https://doi.org/10.2147/ccid.S50546
  4. Alijotas‐Reig J, Fernandez‐Figueras MT, Puig L. Inflammatory, immune‐mediated adverse reactions related to soft tissue dermal fillers. Semin Arthritis Rheum. 2013;43(2):241‐258.  https://doi.org/10.1016/j.semarthrit.2013.02.001
  5. Bhojani‐Lynch T. Late‐onset inflammatory response to hyaluronic acid dermal fillers. Plast Reconstr Surg Glob Open. 2017;5(12):e1532. https://doi.org/10.1097/GOX.0000000000001532
  6. Turkmani MG, De Boulle K, Philipp‐Dormston WG. Delayed hypersensitivity reaction to hyaluronic acid dermal filler following influenza‐like illness. Clin Cosmet Investig Dermatol. 2019;12:277‐283.  https://doi.org/10.2147/ccid.S198081
  7. Rowland‐Warmann MJ. Hypersensitivity reaction to hyaluronic acid dermal filler following novel coronavirus infection — a case report. J Cosmet Dermatol. 2021;20(5):1557-1562. https://doi.org/10.1111/jocd.14074
  8. Michon A. Hyaluronic acid soft tissue filler delayed inflammatory reaction following COVID-19 vaccination — a case report. Journal of Cosmetic Dermatology. 2021;20(9):2684-2690. https://doi.org/10.1111/jocd.14312
  9. Ikonnikova EV, Manturova NE, Kruglova LS. Delayed inflammatory response to hyaluronic acid fillers in the setting of influenza-like illness. Russian Journal of Skin and Venereal Diseases. 2021;24(1):93-100. (In Russ.). https://doi.org/10.17816/dv61472
  10. Ikonnikova EV, Kruglova LS. Delayed immuno-inflammatory response after injection of a hyaluronic acid-based filler: a clinical case. Pharmateca. 2019;8:88-91. (In Russ.). https://doi.org/10.18565/pharmateca.2019.8.88-91.
  11. Zielke H, Wölbe L, Wiest L, Rzany B. Risk profiles of different injectable fillers: results from the injectable filler safety study (IFS study). Dermatol Surg. 2008;34(3):326-335.  https://doi.org/10.1111/j.1524-4725.2007.34066.x
  12. D’Acunto C, Pazzaglia M, Raone B, Misciali C, Badiali L, Neri I, et al. Xanthelasma palpebrarum: a new adverse reaction to intradermal fillers? Br J Dermatol. 2013;168(2):437-439. 2012  https://doi.org/10.1111/j.1365-2133.2012.11152.x
  13. Zak A, Zeman M, Slaby A, Vecka M. Xanthomas: clinical and pathophysiological relations. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014;158(2):181-188.  https://doi.org/10.5507/bp.2014.016
  14. Wang P, Luo Q, Tang L. Bilateral extensive nodular xanthelasma palpebrarum: an infrequent case report. Int Ophthalmol. 2018;38(2):803-805.  https://doi.org/10.1007/s10792-017-0506-6
  15. Kavoussi H, Ebrahimi A, Rezaei M, Ramezani M, Najafi B, Kavoussi R. Serum lipid profile and clinical characteristics of patients with xanthelasma palpebrarum. An Bras Dermatol. 2016;91(4):468-471.  https://doi.org/10.1590/abd1806-4841.20164607
  16. Nair PA, Singhal R. Xanthelasma palpebrarum — a brief review. Clin Cosmet Investig Dermatol. 2018;11:1-5.  https://doi.org/10.2147/CCID.S130116
  17. Laftah Z, Al-Niaimi F. Xanthelasma: An Update on Treatment Modalities. J Cutan Aesthet Surg. 2018;11(1):1-6.  https://doi.org/10.4103/JCAS.JCAS_56_17
  18. Raulin C, Schoenermark MP, Werner S, Greve B. Xanthelasma palpebrarum: treatment with the ultrapulsed CO2 laser. Lasers Surg Med. 1999;24(2): 122-127. https://doi.org/10.1002/(SICI)1096-9101(1999)24:2<122::AID-LSM7>3.0.CO;2-6 "> 3.0.CO;2-6" target="_blank">https://doi.org/10.1002/(SICI)1096-9101(1999)24:2<122::AID-LSM7>3.0.CO;2-6
  19. Hurt-Camejo E, Camejo G, Rosengren B, López F, Ahlström C, Fager G, et al. Effect of arterial proteoglycans and glycosaminoglycans on low density lipoprotein oxidation and its uptake by human macrophages and arterial smooth muscle cells. Arterioscler Thromb. 1992;12(5):569-583.  https://doi.org/10.1161/01.atv.12.5.569
  20. Seike M, Ikeda M, Matsumoto M, et al. Hyaluronan forms complexes with low density lipoprotein while also inducing foam cell infiltration in the dermis. J Dermatol Sci. 2006;41:197-204.  https://doi.org/10.1016/j.jdermsci.2005.10.008
  21. Kim MW, Park HS, Yoon HS, Cho S. Late-Onset Complication of Fillers: Paraffinoma of the Lower Eyelids Clinically Mimicking Xanthelasma. Ann Dermatol. 2016;28(6):753-756.  https://doi.org/10.5021/ad.2016.28.6.753
  22. Or L, Eviatar JA, Massry GG, Bernardini FP, Hartstein ME. Xanthelasma-Like Reaction to Filler Injection. Ophthalmic Plast Reconstr Surg. 2017;33(4):244-247.  https://doi.org/10.1097/IOP.0000000000000722
  23. Curtis JA, Tristani-Firouzi P, Bowen AR. Xanthelasma palpebrarum after Artecoll (polymethylmethacrylate collagen) injections to the bilateral tear troughs. The American Journal of Dermatopathology. 2017;39 (7):553-554.  https://doi.org/10.1097/DAD.0000000000000642
  24. Liu A, Kollipara R, Hoss E, Goldman MP. Lower eyelid xanthelasma following hyaluronic acid filler injections to the tear troughs. J Cosmet Dermatol. 2021;20(10):3190-3192  https://doi.org/10.1111/jocd.14166
  25. Pires VS, Wender IO, Santos MF, Sartori GL, Vivian A, Dallagnese G. Xanthelasma palpebrarum after hyaluronic acid injection in the lower eyelid: a case report and review of the literature. J Cosmet Dermatol. 2021;20(9):2750-2752. https://doi.org/10.1111/jocd.13930
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