Acne is a common disease that causes physical and psychological discomfort that affects the life quality. For the etiology, pathogenesis and sanogenetc treatment of acne the drugs with antibacterial, lipotropic and cytoregulatory action were justified that is generally realized in anti-acne effects.

OBJECTIVE

To evaluate the external therapy effectiveness for mild papulo-pustular forms including an antibacterial agent and an anti-acne drug with a combined action based on azelaic acid.

MATERIAL AND METHODS

It was examined 22 patients (average age 25±9 years) including 13 women and 9 men who received local therapy as following: 15% gel with azelaic acid and after 15 minutes 1% gel with clindamycin phosphate for 8 weeks 2 times a day. The effectiveness of therapy was assessed by skin manifestations’ dynamics and the dermatological life quality index (DLQI).

RESULTS

Treatment was effective 2 weeks after initiation. The main manifestations of the disease were stopped, the life quality of patients increased. By the end of the observation (8 weeks), almost all patients showed a positive therapy effect.

CONCLUSION

The combined use of topical agents with anti-acne and antibacterial effect for mild acne is justified. For effective treatment it is necessary to follow the drugs’ usage sequence: at first, drugs with azelaic acid, then with clindamycin that chronologically ensures the restoration of the drainage function of the sebaceous glands ducts with the subsequent suppression of the bacterial flora activity. Such treatment can be effective for moderate and severe acne as a part of complex therapy.