COVID-19 manifests itself in patients with damage to many organs and systems of the body, primarily the respiratory and cardiovascular systems. At the same time, there are reports of various manifestations of skin lesions in COVID-19. We present a clinical case of skin lesions in a patient with a severe coronavirus infection. Patient G., 56 years old, was admitted to the «COVID» hospital 10 days after disease onset. The examination revealed severe respiratory failure with a decrease in blood oxygen saturation to 80% and a specific lesion of the lungs (80%) according to computed tomography. The patient received high doses of oxygen intra-nasally, but later due to low oxygen saturation she was transferred to the intensive care unit where she underwent non-invasive ventilation. The skin lesion developed 1 month after admission to the hospital and manifested itself as small grouped papular rashes on an erythematous background localized on the left thigh and popliteal fossa. The appearance of exanthema coincided with the 3^rd episode of an increase in the level of C-reactive protein in the blood. When the patient was discharged from the hospital (on the 40^th day of hospitalization) with positive dynamics of the general condition a significant decrease in skin rashes was observed.